The expression of HSPs, anti-oxidants, and cytokines in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome

Eun Joo Lee, Ji Youn Lim, Sang Yeub Lee, Seung Heon Lee, Kwang Ho In, Se Hwa Yoo, Dong Geun Sul, Sanghoon Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: We studied several acute inflammatory materials (AIM) such as various inflammatory cytokines, oxidative stress, and heat shock proteins in ARDS patients by simultaneously measuring from bronchoalveolar lavage fluid (BALF) and plasma. Design and methods: AIM were measured by using plasma and BALF sampling obtained from ARDS group (n = 12) and non-ARDS group (n = 12). Results: In the BALF, only HSP 47 was significantly increased in ARDS group than non-ARDS group. In plasma, GRP 94, HSP 90, HSP 60, HSP 47, GPx-3, and IL-8 were increased significantly in ARDS group. In short, most of the AIM in BALF or plasma were not significantly different in ARDS group as compared with non-ARDS group. Ninety-day mortality was significantly related to HSP90, HSP 60 and GPx-3 in plasma but not in BALF. Conclusion: Alteration of AIM levels in both BALF or plasma of ARDS group was not remarkable compared with the non-ARDS group. Our result suggests the need to reconsider ARDS pathophysiology and therapeutic strategy.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalClinical Biochemistry
Volume45
Issue number6
DOIs
Publication statusPublished - 2012 Apr 1

Fingerprint

Adult Respiratory Distress Syndrome
Bronchoalveolar Lavage Fluid
Oxidants
Cytokines
Plasmas
Fluids
Oxidative stress
Heat-Shock Proteins
Interleukin-8
Oxidative Stress
Sampling
Mortality

Keywords

  • Acute respiratory distress syndrome
  • Anti-oxidant
  • Cytokine
  • Heat shock protein

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

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title = "The expression of HSPs, anti-oxidants, and cytokines in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome",
abstract = "Objectives: We studied several acute inflammatory materials (AIM) such as various inflammatory cytokines, oxidative stress, and heat shock proteins in ARDS patients by simultaneously measuring from bronchoalveolar lavage fluid (BALF) and plasma. Design and methods: AIM were measured by using plasma and BALF sampling obtained from ARDS group (n = 12) and non-ARDS group (n = 12). Results: In the BALF, only HSP 47 was significantly increased in ARDS group than non-ARDS group. In plasma, GRP 94, HSP 90, HSP 60, HSP 47, GPx-3, and IL-8 were increased significantly in ARDS group. In short, most of the AIM in BALF or plasma were not significantly different in ARDS group as compared with non-ARDS group. Ninety-day mortality was significantly related to HSP90, HSP 60 and GPx-3 in plasma but not in BALF. Conclusion: Alteration of AIM levels in both BALF or plasma of ARDS group was not remarkable compared with the non-ARDS group. Our result suggests the need to reconsider ARDS pathophysiology and therapeutic strategy.",
keywords = "Acute respiratory distress syndrome, Anti-oxidant, Cytokine, Heat shock protein",
author = "Lee, {Eun Joo} and Lim, {Ji Youn} and Lee, {Sang Yeub} and Lee, {Seung Heon} and In, {Kwang Ho} and Yoo, {Se Hwa} and Sul, {Dong Geun} and Sanghoon Park",
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T1 - The expression of HSPs, anti-oxidants, and cytokines in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome

AU - Lee, Eun Joo

AU - Lim, Ji Youn

AU - Lee, Sang Yeub

AU - Lee, Seung Heon

AU - In, Kwang Ho

AU - Yoo, Se Hwa

AU - Sul, Dong Geun

AU - Park, Sanghoon

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Objectives: We studied several acute inflammatory materials (AIM) such as various inflammatory cytokines, oxidative stress, and heat shock proteins in ARDS patients by simultaneously measuring from bronchoalveolar lavage fluid (BALF) and plasma. Design and methods: AIM were measured by using plasma and BALF sampling obtained from ARDS group (n = 12) and non-ARDS group (n = 12). Results: In the BALF, only HSP 47 was significantly increased in ARDS group than non-ARDS group. In plasma, GRP 94, HSP 90, HSP 60, HSP 47, GPx-3, and IL-8 were increased significantly in ARDS group. In short, most of the AIM in BALF or plasma were not significantly different in ARDS group as compared with non-ARDS group. Ninety-day mortality was significantly related to HSP90, HSP 60 and GPx-3 in plasma but not in BALF. Conclusion: Alteration of AIM levels in both BALF or plasma of ARDS group was not remarkable compared with the non-ARDS group. Our result suggests the need to reconsider ARDS pathophysiology and therapeutic strategy.

AB - Objectives: We studied several acute inflammatory materials (AIM) such as various inflammatory cytokines, oxidative stress, and heat shock proteins in ARDS patients by simultaneously measuring from bronchoalveolar lavage fluid (BALF) and plasma. Design and methods: AIM were measured by using plasma and BALF sampling obtained from ARDS group (n = 12) and non-ARDS group (n = 12). Results: In the BALF, only HSP 47 was significantly increased in ARDS group than non-ARDS group. In plasma, GRP 94, HSP 90, HSP 60, HSP 47, GPx-3, and IL-8 were increased significantly in ARDS group. In short, most of the AIM in BALF or plasma were not significantly different in ARDS group as compared with non-ARDS group. Ninety-day mortality was significantly related to HSP90, HSP 60 and GPx-3 in plasma but not in BALF. Conclusion: Alteration of AIM levels in both BALF or plasma of ARDS group was not remarkable compared with the non-ARDS group. Our result suggests the need to reconsider ARDS pathophysiology and therapeutic strategy.

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KW - Cytokine

KW - Heat shock protein

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