Abstract
Objectives: We studied several acute inflammatory materials (AIM) such as various inflammatory cytokines, oxidative stress, and heat shock proteins in ARDS patients by simultaneously measuring from bronchoalveolar lavage fluid (BALF) and plasma. Design and methods: AIM were measured by using plasma and BALF sampling obtained from ARDS group (n = 12) and non-ARDS group (n = 12). Results: In the BALF, only HSP 47 was significantly increased in ARDS group than non-ARDS group. In plasma, GRP 94, HSP 90, HSP 60, HSP 47, GPx-3, and IL-8 were increased significantly in ARDS group. In short, most of the AIM in BALF or plasma were not significantly different in ARDS group as compared with non-ARDS group. Ninety-day mortality was significantly related to HSP90, HSP 60 and GPx-3 in plasma but not in BALF. Conclusion: Alteration of AIM levels in both BALF or plasma of ARDS group was not remarkable compared with the non-ARDS group. Our result suggests the need to reconsider ARDS pathophysiology and therapeutic strategy.
| Original language | English |
|---|---|
| Pages (from-to) | 493-498 |
| Number of pages | 6 |
| Journal | Clinical Biochemistry |
| Volume | 45 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2012 Apr 1 |
Fingerprint
Keywords
- Acute respiratory distress syndrome
- Anti-oxidant
- Cytokine
- Heat shock protein
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
The expression of HSPs, anti-oxidants, and cytokines in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. / Lee, Eun Joo; Lim, Ji Youn; Lee, Sang Yeub; Lee, Seung Heon; In, Kwang Ho; Yoo, Se Hwa; Sul, Dong Geun; Park, Sanghoon.
In: Clinical Biochemistry, Vol. 45, No. 6, 01.04.2012, p. 493-498.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The expression of HSPs, anti-oxidants, and cytokines in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome
AU - Lee, Eun Joo
AU - Lim, Ji Youn
AU - Lee, Sang Yeub
AU - Lee, Seung Heon
AU - In, Kwang Ho
AU - Yoo, Se Hwa
AU - Sul, Dong Geun
AU - Park, Sanghoon
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Objectives: We studied several acute inflammatory materials (AIM) such as various inflammatory cytokines, oxidative stress, and heat shock proteins in ARDS patients by simultaneously measuring from bronchoalveolar lavage fluid (BALF) and plasma. Design and methods: AIM were measured by using plasma and BALF sampling obtained from ARDS group (n = 12) and non-ARDS group (n = 12). Results: In the BALF, only HSP 47 was significantly increased in ARDS group than non-ARDS group. In plasma, GRP 94, HSP 90, HSP 60, HSP 47, GPx-3, and IL-8 were increased significantly in ARDS group. In short, most of the AIM in BALF or plasma were not significantly different in ARDS group as compared with non-ARDS group. Ninety-day mortality was significantly related to HSP90, HSP 60 and GPx-3 in plasma but not in BALF. Conclusion: Alteration of AIM levels in both BALF or plasma of ARDS group was not remarkable compared with the non-ARDS group. Our result suggests the need to reconsider ARDS pathophysiology and therapeutic strategy.
AB - Objectives: We studied several acute inflammatory materials (AIM) such as various inflammatory cytokines, oxidative stress, and heat shock proteins in ARDS patients by simultaneously measuring from bronchoalveolar lavage fluid (BALF) and plasma. Design and methods: AIM were measured by using plasma and BALF sampling obtained from ARDS group (n = 12) and non-ARDS group (n = 12). Results: In the BALF, only HSP 47 was significantly increased in ARDS group than non-ARDS group. In plasma, GRP 94, HSP 90, HSP 60, HSP 47, GPx-3, and IL-8 were increased significantly in ARDS group. In short, most of the AIM in BALF or plasma were not significantly different in ARDS group as compared with non-ARDS group. Ninety-day mortality was significantly related to HSP90, HSP 60 and GPx-3 in plasma but not in BALF. Conclusion: Alteration of AIM levels in both BALF or plasma of ARDS group was not remarkable compared with the non-ARDS group. Our result suggests the need to reconsider ARDS pathophysiology and therapeutic strategy.
KW - Acute respiratory distress syndrome
KW - Anti-oxidant
KW - Cytokine
KW - Heat shock protein
UR - http://www.scopus.com/inward/record.url?scp=84862776794&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862776794&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2012.01.020
DO - 10.1016/j.clinbiochem.2012.01.020
M3 - Article
VL - 45
SP - 493
EP - 498
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
IS - 6
ER -