The expression of non-clustered protocadherins in adult rat hippocampal formation and the connecting brain regions

S. Y. Kim; J. W. Mo; S. Han; S. Y. Choi; S. B. Han; B. H. Moon; I. J. Rhyu; W. Sun; H. Kim

doi:10.1016/j.neuroscience.2010.05.027

The expression of non-clustered protocadherins in adult rat hippocampal formation and the connecting brain regions

S. Y. Kim, J. W. Mo, S. Han, S. Y. Choi, S. B. Han, B. H. Moon, I. J. Rhyu, W. Sun, H. Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

Non-clustered protocadherins (PCDHs) are calcium-dependent adhesion molecules which have attracted attention for their possible roles in the neuronal circuit formation during development and their implications in the neurological disorders such as autism and mental retardation. Previously, we found that a subset of the non-clustered PCDHs exhibited circuit-dependent expression patterns in thalamo-cortical connections in early postnatal rat brain, but such patterns disappeared in adulthood. In this study, we identified that the non-clustered PCDHs showed differential expression patterns along the septotemporal axis in the subregions of adult hippocampus and dentate gyrus with topographical preferences. The expressions of PCDH1, PCDH9, PCDH10 and PCDH20 showed septal preferences, whereas the expressions of PCDH8, PCDH11, PCDH17 and PCDH19 showed temporal preferences, suggesting that they play roles in the formation/maintenance of intrahippocampal circuits. PCDHs also exhibited the region-specific expression patterns in the areas connected to hippocampal formation such as entorhinal cortex, lateral septum, and basolateral amygdaloid complex. Furthermore, the expression levels of three PCDHs (PCDH8, PCDH19 and PCDH20) were regulated by the electroconvulsive shock stimulation of the brain in the adult hippocampus and dentate gyrus. These results suggest that non-clustered PCDHs are involved in the maintenance and plasticity of adult hippocampal circuitry.

Original language	English
Pages (from-to)	189-199
Number of pages	11
Journal	Neuroscience
Volume	170
Issue number	1
DOIs	https://doi.org/10.1016/j.neuroscience.2010.05.027
Publication status	Published - 2010 Sept

Keywords

Amygdaloid complex
Electroconvulsive shock
Entorhinal cortex
Gene expression
Hippocampus and dentate gyrus
Septum

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuroscience.2010.05.027

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@article{197f5943e58a4fc3ba38e0fbe7162567,

title = "The expression of non-clustered protocadherins in adult rat hippocampal formation and the connecting brain regions",

abstract = "Non-clustered protocadherins (PCDHs) are calcium-dependent adhesion molecules which have attracted attention for their possible roles in the neuronal circuit formation during development and their implications in the neurological disorders such as autism and mental retardation. Previously, we found that a subset of the non-clustered PCDHs exhibited circuit-dependent expression patterns in thalamo-cortical connections in early postnatal rat brain, but such patterns disappeared in adulthood. In this study, we identified that the non-clustered PCDHs showed differential expression patterns along the septotemporal axis in the subregions of adult hippocampus and dentate gyrus with topographical preferences. The expressions of PCDH1, PCDH9, PCDH10 and PCDH20 showed septal preferences, whereas the expressions of PCDH8, PCDH11, PCDH17 and PCDH19 showed temporal preferences, suggesting that they play roles in the formation/maintenance of intrahippocampal circuits. PCDHs also exhibited the region-specific expression patterns in the areas connected to hippocampal formation such as entorhinal cortex, lateral septum, and basolateral amygdaloid complex. Furthermore, the expression levels of three PCDHs (PCDH8, PCDH19 and PCDH20) were regulated by the electroconvulsive shock stimulation of the brain in the adult hippocampus and dentate gyrus. These results suggest that non-clustered PCDHs are involved in the maintenance and plasticity of adult hippocampal circuitry.",

keywords = "Amygdaloid complex, Electroconvulsive shock, Entorhinal cortex, Gene expression, Hippocampus and dentate gyrus, Septum",

author = "Kim, {S. Y.} and Mo, {J. W.} and S. Han and Choi, {S. Y.} and Han, {S. B.} and Moon, {B. H.} and Rhyu, {I. J.} and W. Sun and H. Kim",

note = "Funding Information: We thank Choi KM and Chin JH for their technical supports. This work was supported by the Korea Science and Engineering Foundation grant ( 2009K001284 to HK, 2009K001259 to WS) funded by the Korean government . A part of this work was technically supported by the core facility service of 21C Frontier Brain Research Center .",

year = "2010",

month = sep,

doi = "10.1016/j.neuroscience.2010.05.027",

language = "English",

volume = "170",

pages = "189--199",

journal = "Neuroscience",

issn = "0306-4522",

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T1 - The expression of non-clustered protocadherins in adult rat hippocampal formation and the connecting brain regions

AU - Kim, S. Y.

AU - Mo, J. W.

AU - Han, S.

AU - Choi, S. Y.

AU - Han, S. B.

AU - Moon, B. H.

AU - Rhyu, I. J.

AU - Sun, W.

AU - Kim, H.

N1 - Funding Information: We thank Choi KM and Chin JH for their technical supports. This work was supported by the Korea Science and Engineering Foundation grant ( 2009K001284 to HK, 2009K001259 to WS) funded by the Korean government . A part of this work was technically supported by the core facility service of 21C Frontier Brain Research Center .

PY - 2010/9

Y1 - 2010/9

N2 - Non-clustered protocadherins (PCDHs) are calcium-dependent adhesion molecules which have attracted attention for their possible roles in the neuronal circuit formation during development and their implications in the neurological disorders such as autism and mental retardation. Previously, we found that a subset of the non-clustered PCDHs exhibited circuit-dependent expression patterns in thalamo-cortical connections in early postnatal rat brain, but such patterns disappeared in adulthood. In this study, we identified that the non-clustered PCDHs showed differential expression patterns along the septotemporal axis in the subregions of adult hippocampus and dentate gyrus with topographical preferences. The expressions of PCDH1, PCDH9, PCDH10 and PCDH20 showed septal preferences, whereas the expressions of PCDH8, PCDH11, PCDH17 and PCDH19 showed temporal preferences, suggesting that they play roles in the formation/maintenance of intrahippocampal circuits. PCDHs also exhibited the region-specific expression patterns in the areas connected to hippocampal formation such as entorhinal cortex, lateral septum, and basolateral amygdaloid complex. Furthermore, the expression levels of three PCDHs (PCDH8, PCDH19 and PCDH20) were regulated by the electroconvulsive shock stimulation of the brain in the adult hippocampus and dentate gyrus. These results suggest that non-clustered PCDHs are involved in the maintenance and plasticity of adult hippocampal circuitry.

AB - Non-clustered protocadherins (PCDHs) are calcium-dependent adhesion molecules which have attracted attention for their possible roles in the neuronal circuit formation during development and their implications in the neurological disorders such as autism and mental retardation. Previously, we found that a subset of the non-clustered PCDHs exhibited circuit-dependent expression patterns in thalamo-cortical connections in early postnatal rat brain, but such patterns disappeared in adulthood. In this study, we identified that the non-clustered PCDHs showed differential expression patterns along the septotemporal axis in the subregions of adult hippocampus and dentate gyrus with topographical preferences. The expressions of PCDH1, PCDH9, PCDH10 and PCDH20 showed septal preferences, whereas the expressions of PCDH8, PCDH11, PCDH17 and PCDH19 showed temporal preferences, suggesting that they play roles in the formation/maintenance of intrahippocampal circuits. PCDHs also exhibited the region-specific expression patterns in the areas connected to hippocampal formation such as entorhinal cortex, lateral septum, and basolateral amygdaloid complex. Furthermore, the expression levels of three PCDHs (PCDH8, PCDH19 and PCDH20) were regulated by the electroconvulsive shock stimulation of the brain in the adult hippocampus and dentate gyrus. These results suggest that non-clustered PCDHs are involved in the maintenance and plasticity of adult hippocampal circuitry.

KW - Amygdaloid complex

KW - Electroconvulsive shock

KW - Entorhinal cortex

KW - Gene expression

KW - Hippocampus and dentate gyrus

KW - Septum

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DO - 10.1016/j.neuroscience.2010.05.027

M3 - Article

C2 - 20541594

AN - SCOPUS:77955917732

SN - 0306-4522

VL - 170

SP - 189

EP - 199

JO - Neuroscience

JF - Neuroscience

IS - 1

ER -

The expression of non-clustered protocadherins in adult rat hippocampal formation and the connecting brain regions

Abstract

Keywords

ASJC Scopus subject areas

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