The flavonoid morin alleviates nuclear deformation in aged cells by disrupting progerin-lamin A/C binding

Jinsook Ahn, Tae Gyun Woo, So mi Kang, Inseong Jo, Jae Sung Woo, Bum Joon Park, Nam Chul Ha

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Nuclear lamin A/C plays an important role in maintaining the nuclear envelope structure. Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a silent mutation in the lamin A/C gene, leading to the production of a C-terminally truncated protein (progerin). A deformed nuclear shape is a hallmark of HGPS cells, which observed in normal aged cells. A recent study has found that progerin can directly interact with lamin A/C, which leads to nuclear deformation. In this study, we identified natural compounds that can disrupt this progerin-mediated interaction. Similar to the synthetic compound JH4, morin disrupted this progerin-mediated interaction. Treatment with 20 μM morin ameliorated nuclear deformation by more than 50% in progerin-expressing cells. As morin is a naturally occurring substance with anti-oxidative activity, it may be developed as a functional food to improve the lifespan and health of both HGPS patients and normal aging individuals.

Original languageEnglish
Article number104331
JournalJournal of Functional Foods
Volume77
DOIs
Publication statusPublished - 2021 Feb

Keywords

  • Anti-aging
  • Hutchinson-Gilford progeria syndrome
  • Morin
  • Nuclear lamin A/C
  • Premature aging syndrome
  • Progerin

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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