The function of PLCγ1 in developing mouse mDA system

Du Seock Kang, Il Shin Kim, Ja-Hyun Baik, Daesoo Kim, Lucio Cocco, Pann Ghill Suh

Research output: Contribution to journalReview article

Abstract

During neural development, growing neuronal cells consistently sense and communicate with their surroundings through the use of signaling molecules. In this process, spatiotemporally well-coordinated intracellular signaling is a prerequisite for proper neuronal network formation. Thus, intense interest has focused on investigating the signaling mechanisms in neuronal structure formation that link the activation of receptors to the control of cell shape and motility. Recent studies suggest that Phospholipase C gamma1 (PLCγ1), a signal transducer, plays key roles in nervous system development by mediating specific ligand-receptor systems. In this overview of the most recent advances in the field, we discuss the mechanisms by which extracellular stimuli trigger PLCγ1 signaling and, the role PLCγ1 in nervous system development.

Original languageEnglish
Article number100654
JournalAdvances in Biological Regulation
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Phospholipase C gamma
Nervous System
Cell Shape
Transducers
Cell Movement
Ligands

Keywords

  • Axon guidance
  • Calcium signaling
  • Cytoskeleton
  • PLCG1

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

The function of PLCγ1 in developing mouse mDA system. / Kang, Du Seock; Kim, Il Shin; Baik, Ja-Hyun; Kim, Daesoo; Cocco, Lucio; Suh, Pann Ghill.

In: Advances in Biological Regulation, 01.01.2019.

Research output: Contribution to journalReview article

Kang, Du Seock ; Kim, Il Shin ; Baik, Ja-Hyun ; Kim, Daesoo ; Cocco, Lucio ; Suh, Pann Ghill. / The function of PLCγ1 in developing mouse mDA system. In: Advances in Biological Regulation. 2019.
@article{2102089495124344aeb7ff76d688ff05,
title = "The function of PLCγ1 in developing mouse mDA system",
abstract = "During neural development, growing neuronal cells consistently sense and communicate with their surroundings through the use of signaling molecules. In this process, spatiotemporally well-coordinated intracellular signaling is a prerequisite for proper neuronal network formation. Thus, intense interest has focused on investigating the signaling mechanisms in neuronal structure formation that link the activation of receptors to the control of cell shape and motility. Recent studies suggest that Phospholipase C gamma1 (PLCγ1), a signal transducer, plays key roles in nervous system development by mediating specific ligand-receptor systems. In this overview of the most recent advances in the field, we discuss the mechanisms by which extracellular stimuli trigger PLCγ1 signaling and, the role PLCγ1 in nervous system development.",
keywords = "Axon guidance, Calcium signaling, Cytoskeleton, PLCG1",
author = "Kang, {Du Seock} and Kim, {Il Shin} and Ja-Hyun Baik and Daesoo Kim and Lucio Cocco and Suh, {Pann Ghill}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jbior.2019.100654",
language = "English",
journal = "Advances in Biological Regulation",
issn = "2212-4926",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - The function of PLCγ1 in developing mouse mDA system

AU - Kang, Du Seock

AU - Kim, Il Shin

AU - Baik, Ja-Hyun

AU - Kim, Daesoo

AU - Cocco, Lucio

AU - Suh, Pann Ghill

PY - 2019/1/1

Y1 - 2019/1/1

N2 - During neural development, growing neuronal cells consistently sense and communicate with their surroundings through the use of signaling molecules. In this process, spatiotemporally well-coordinated intracellular signaling is a prerequisite for proper neuronal network formation. Thus, intense interest has focused on investigating the signaling mechanisms in neuronal structure formation that link the activation of receptors to the control of cell shape and motility. Recent studies suggest that Phospholipase C gamma1 (PLCγ1), a signal transducer, plays key roles in nervous system development by mediating specific ligand-receptor systems. In this overview of the most recent advances in the field, we discuss the mechanisms by which extracellular stimuli trigger PLCγ1 signaling and, the role PLCγ1 in nervous system development.

AB - During neural development, growing neuronal cells consistently sense and communicate with their surroundings through the use of signaling molecules. In this process, spatiotemporally well-coordinated intracellular signaling is a prerequisite for proper neuronal network formation. Thus, intense interest has focused on investigating the signaling mechanisms in neuronal structure formation that link the activation of receptors to the control of cell shape and motility. Recent studies suggest that Phospholipase C gamma1 (PLCγ1), a signal transducer, plays key roles in nervous system development by mediating specific ligand-receptor systems. In this overview of the most recent advances in the field, we discuss the mechanisms by which extracellular stimuli trigger PLCγ1 signaling and, the role PLCγ1 in nervous system development.

KW - Axon guidance

KW - Calcium signaling

KW - Cytoskeleton

KW - PLCG1

UR - http://www.scopus.com/inward/record.url?scp=85072542710&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072542710&partnerID=8YFLogxK

U2 - 10.1016/j.jbior.2019.100654

DO - 10.1016/j.jbior.2019.100654

M3 - Review article

AN - SCOPUS:85072542710

JO - Advances in Biological Regulation

JF - Advances in Biological Regulation

SN - 2212-4926

M1 - 100654

ER -