The function of PLCγ1 in developing mouse mDA system

Du Seock Kang, Il Shin Kim, Ja-Hyun Baik, Daesoo Kim, Lucio Cocco, Pann Ghill Suh

Research output: Contribution to journalReview article

Abstract

During neural development, growing neuronal cells consistently sense and communicate with their surroundings through the use of signaling molecules. In this process, spatiotemporally well-coordinated intracellular signaling is a prerequisite for proper neuronal network formation. Thus, intense interest has focused on investigating the signaling mechanisms in neuronal structure formation that link the activation of receptors to the control of cell shape and motility. Recent studies suggest that Phospholipase C gamma1 (PLCγ1), a signal transducer, plays key roles in nervous system development by mediating specific ligand-receptor systems. In this overview of the most recent advances in the field, we discuss the mechanisms by which extracellular stimuli trigger PLCγ1 signaling and, the role PLCγ1 in nervous system development.

Original languageEnglish
Article number100654
JournalAdvances in Biological Regulation
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Keywords

  • Axon guidance
  • Calcium signaling
  • Cytoskeleton
  • PLCG1

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Cancer Research

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