The functional p53 codon 72 polymorphism is associated with systemic lupus erythematosus

Young Ho Lee, Y. H. Rho, S. J. Choi, J. D. Ji, G. G. Song

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    17 Citations (Scopus)

    Abstract

    The aim of the study is to investigate whether the functional p53 codon 72 polymorphism is associated with susceptibility to SLE and its clinical features. A polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the p53 codon 72 in 90 SLE patients and 114 healthy controls. Clinical/serological manifestations were analysed in each patient and correlated with the genotypes. The OR of the association of the Pro allele with SLE was 1.70 (95% CI, 1.15-2.53, P = 0.0079) and the OR of the Pro/Pro (a recessive model) was significantly increased (OR = 2.58, 95% CI = 1.24-5.39, P = 0.0093). The Armitage's trend test indicated a significant dosage effect of the Pro allele for SLE (OR = 1.73, chi-square = 7.08, P = 0.0078). However, there was no significant association of the polymorphism with clinical/serological manifestations studied here. In conclusion, our finding suggests the functional p53 codon 72 polymorphism may be associated with SLE susceptibility, suggesting individuals who carry the Pro allele may have a higher risk to SLE susceptibility than those with the Arg allele. Further studies for replications are needed to confirm that the p53 polymorphism contributes to SLE.

    Original languageEnglish
    Pages (from-to)842-845
    Number of pages4
    JournalLupus
    Volume14
    Issue number10
    DOIs
    Publication statusPublished - 2005

    Keywords

    • Polymorphisms
    • Systemic lupus erythematosus
    • p53

    ASJC Scopus subject areas

    • Rheumatology

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