The G allele in IL-10-1082 G/A may have a role in lowering the susceptibility to panic disorder in female patients

Han Joon Kim, Yong Ku Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Immune system activation is involved in the pathophysiology of panic disorder (PD). We investigated INF-γ+874 A/T, TNF-α-308 G/A, and IL-10-1082 G/A single nucleotide polymorphisms (SNPs) to determine their association with PD. Method: This study enroled 135 PD patients and 135 healthy controls. INF-γ+874 A/T (rs2430561), TNF-α-308 G/A (rs1800629), and IL-10-1082 G/A (rs1800896) were genotyped. Results: There were no differences in genotypes or allele frequencies between the patient and control groups, regardless of accompanying agoraphobia. However, for female patients, the G allele frequency in IL-10 SNP was higher in the control group than in the patient group. Additionally, the female control group had a higher frequency of the A/G and G/G genotype in the IL-10 SNP than the female patient group. Conclusion: We suggest that the G allele in IL-10-1082 G/A might have a role in reducing the manifestations of PD in female patients. Further studies are needed to extend and confirm our findings.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalActa Neuropsychiatrica
Volume28
Issue number6
DOIs
Publication statusPublished - 2016 Dec 1

    Fingerprint

Keywords

  • cytokine
  • IFN-r
  • IL-10
  • panic disorder
  • TNF-α

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this