The genome of the natural genetic engineer Agrobacterium tumefaciens C58

D. W. Wood; J. C. Setubal; R. Kaul; D. E. Monks; J. P. Kitajima; V. K. Okura; Y. Zhou; L. Chen; G. E. Wood; Jr Almeida; L. Woo; Y. Chen; I. T. Paulsen; J. A. Eisen; P. D. Karp; Sr Bovee D.; P. Chapman; J. Clendenning; G. Deatherage; W. Gillet; C. Grant; T. Kutyavin; R. Levy; M. J. Li; E. McClelland; A. Palmieri; C. Raymond; G. Rouse; C. Saenphimmachak; Z. Wu; P. Romero; D. Gordon; S. Zhang; H. Yoo; Y. Tao; P. Biddle; M. Jung; W. Krespan; M. Perry; B. Gordon-Kamm; L. Liao; S. Kim; C. Hendrick; Z. Y. Zhao; M. Dolan; F. Chumley; S. V. Tingey; J. F. Tomb; M. P. Gordon; M. V. Olson; E. W. Nester

doi:10.1126/science.1066804

The genome of the natural genetic engineer Agrobacterium tumefaciens C58

D. W. Wood, J. C. Setubal, R. Kaul, D. E. Monks, J. P. Kitajima, V. K. Okura, Y. Zhou, L. Chen, G. E. Wood, Jr Almeida, L. Woo, Y. Chen, I. T. Paulsen, J. A. Eisen, P. D. Karp, Sr Bovee D., P. Chapman, J. Clendenning, G. Deatherage, W. GilletC. Grant, T. Kutyavin, R. Levy, M. J. Li, E. McClelland, A. Palmieri, C. Raymond, G. Rouse, C. Saenphimmachak, Z. Wu, P. Romero, D. Gordon, S. Zhang, H. Yoo, Y. Tao, P. Biddle, M. Jung, W. Krespan, M. Perry, B. Gordon-Kamm, L. Liao, S. Kim, C. Hendrick, Z. Y. Zhao, M. Dolan, F. Chumley, S. V. Tingey, J. F. Tomb, M. P. Gordon, M. V. Olson, E. W. Nester

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Abstract

The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.

Original language	English
Pages (from-to)	2317-2323
Number of pages	7
Journal	Science
Volume	294
Issue number	5550
DOIs	https://doi.org/10.1126/science.1066804
Publication status	Published - 2001 Dec 14
Externally published	Yes

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Wood, D. W., Setubal, J. C., Kaul, R., Monks, D. E., Kitajima, J. P., Okura, V. K., Zhou, Y., Chen, L., Wood, G. E., Almeida, J., Woo, L., Chen, Y., Paulsen, I. T., Eisen, J. A., Karp, P. D., Bovee D., S., Chapman, P., Clendenning, J., Deatherage, G., ... Nester, E. W. (2001). The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science, 294(5550), 2317-2323. https://doi.org/10.1126/science.1066804

Wood, DW, Setubal, JC, Kaul, R, Monks, DE, Kitajima, JP, Okura, VK, Zhou, Y, Chen, L, Wood, GE, Almeida, J, Woo, L, Chen, Y, Paulsen, IT, Eisen, JA, Karp, PD, Bovee D., S, Chapman, P, Clendenning, J, Deatherage, G, Gillet, W, Grant, C, Kutyavin, T, Levy, R, Li, MJ, McClelland, E, Palmieri, A, Raymond, C, Rouse, G, Saenphimmachak, C, Wu, Z, Romero, P, Gordon, D, Zhang, S, Yoo, H, Tao, Y, Biddle, P, Jung, M, Krespan, W, Perry, M, Gordon-Kamm, B, Liao, L, Kim, S, Hendrick, C, Zhao, ZY, Dolan, M, Chumley, F, Tingey, SV, Tomb, JF, Gordon, MP, Olson, MV & Nester, EW 2001, 'The genome of the natural genetic engineer Agrobacterium tumefaciens C58', Science, vol. 294, no. 5550, pp. 2317-2323. https://doi.org/10.1126/science.1066804

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title = "The genome of the natural genetic engineer Agrobacterium tumefaciens C58",

abstract = "The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.",

author = "Wood, {D. W.} and Setubal, {J. C.} and R. Kaul and Monks, {D. E.} and Kitajima, {J. P.} and Okura, {V. K.} and Y. Zhou and L. Chen and Wood, {G. E.} and Jr Almeida and L. Woo and Y. Chen and Paulsen, {I. T.} and Eisen, {J. A.} and Karp, {P. D.} and {Bovee D.}, Sr and P. Chapman and J. Clendenning and G. Deatherage and W. Gillet and C. Grant and T. Kutyavin and R. Levy and Li, {M. J.} and E. McClelland and A. Palmieri and C. Raymond and G. Rouse and C. Saenphimmachak and Z. Wu and P. Romero and D. Gordon and S. Zhang and H. Yoo and Y. Tao and P. Biddle and M. Jung and W. Krespan and M. Perry and B. Gordon-Kamm and L. Liao and S. Kim and C. Hendrick and Zhao, {Z. Y.} and M. Dolan and F. Chumley and Tingey, {S. V.} and Tomb, {J. F.} and Gordon, {M. P.} and Olson, {M. V.} and Nester, {E. W.}",

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AU - Setubal, J. C.

AU - Kaul, R.

AU - Monks, D. E.

AU - Kitajima, J. P.

AU - Okura, V. K.

AU - Zhou, Y.

AU - Chen, L.

AU - Wood, G. E.

AU - Almeida, Jr

AU - Woo, L.

AU - Chen, Y.

AU - Paulsen, I. T.

AU - Eisen, J. A.

AU - Karp, P. D.

AU - Bovee D., Sr

AU - Chapman, P.

AU - Clendenning, J.

AU - Deatherage, G.

AU - Gillet, W.

AU - Grant, C.

AU - Kutyavin, T.

AU - Levy, R.

AU - Li, M. J.

AU - McClelland, E.

AU - Palmieri, A.

AU - Raymond, C.

AU - Rouse, G.

AU - Saenphimmachak, C.

AU - Wu, Z.

AU - Romero, P.

AU - Gordon, D.

AU - Zhang, S.

AU - Yoo, H.

AU - Tao, Y.

AU - Biddle, P.

AU - Jung, M.

AU - Krespan, W.

AU - Perry, M.

AU - Gordon-Kamm, B.

AU - Liao, L.

AU - Kim, S.

AU - Hendrick, C.

AU - Zhao, Z. Y.

AU - Dolan, M.

AU - Chumley, F.

AU - Tingey, S. V.

AU - Tomb, J. F.

AU - Gordon, M. P.

AU - Olson, M. V.

AU - Nester, E. W.

PY - 2001/12/14

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JO - Science

JF - Science

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ER -

The genome of the natural genetic engineer Agrobacterium tumefaciens C58

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