The glutamatergic N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors in the joint contribute to the induction, but not maintenance, of arthritic pain in rats

Guo Hua Zhang, Young Wook Yoon, Kyu Sang Lee, Sun Seek Min, Seung Kil Hong, Ji Yong Park, Hee Chul Han

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To determine whether both the N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the knee joint contribute to the induction and/or maintenance of arthritic pain, we examined the effects of intra-articular injection of NMDA receptor antagonist dizocilpine (MK-801) and non-NMDA receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline (NBQX) on the decrease in weight load induced by carrageenan injection into the knee joint cavity in rats. Injection of MK-801 (0.75 and 1.5 mM) and NBQX (0.25, 0.625 and 2.5 mM) immediately prior to carrageenan injection (2%, 40 μl) significantly prevented the pain-related behavior. However, injection of MK-801 (0.75 and 1.5 mM) and NBQX (0.625 and 2.5 mM) 5 h after carrageenan injection had no effect on pain-related behavior. These results suggest that both the NMDA and non-NMDA receptors in the knee joint are involved in the induction, but not maintenance, of arthritic pain.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalNeuroscience Letters
Volume351
Issue number3
DOIs
Publication statusPublished - 2003 Nov 20

Keywords

  • 2,3-Dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline
  • Arthritis
  • Dizocilpine
  • N-methyl-D-aspartate receptor
  • Non-N-methyl-D-aspartate receptor
  • Pain

ASJC Scopus subject areas

  • Neuroscience(all)

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