The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality

Ho Jun Chin, Hyun Jin Cho, Tae Woo Lee, Ki Young Na, Hyung Jin Yoon, Dong Wan Chae, Suhnggwon Kim, Un Sil Jeon, Jun Young Do, Jong Won Park, Kyung Woo Yoon, Young Tai Shin, Kang Wook Lee, Ki Ryang Na, Dae-Ryong Cha, Young Sun Kang, Eun Hee Jang, Won Kim, Nam Ho Kim, Woo Kyun Bae & 53 others Hye Young Kim, Ki Sung Ahn, Jong Tae Cho, Eun Kyeong Lee, Ki Hyun Kim, Won Suk An, Seong Eun Kim, Choi Gyu Bog, Seung Jung Kim, Woo Kyung Chung, Hyun Hee Lee, Jaeseok Yang, Sejoong Kim, Se Ho Chang, Jung Woo Noh, Young Ki Lee, Seong Gyun Kim, Jieun Oh, Young Rim Song, Moon Jae Kim, Seoung Woo Lee, Yeong Hoon Kim, Won Do Park, Hyun Chul Kim, Sung Bae Park, Kyo Soon Kim, Won Yong Cho, Hyoung Kyu Kim, Sang Kyung Jo, Cha Dae Ryong, Kang Young Sun, Young-Joo Kwon, Yong Lim Kim, Sun Hee Park, Chan Duck Kim, Dong Ho Yang, Ihm Soo Kwak, Soo Bong Lee, Dong Won Lee, Sang Heon Song, Eun Young Seoung, Su Jin Yoon, Chun Soo Lim, Yoon Kyu Oh, Kook Hwan Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn, Jin Suk Han, Kyu Beck Lee, Yoon Goo Kim, Jung Eun Lee, Sang Koo Lee

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 at diagnosis. The short (S: <23), medium (M: 23-28), and long (L: >28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients.

Original languageEnglish
JournalJournal of Korean Medical Science
Volume24
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2009 Jan 1

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Heme Oxygenase-1
Immunoglobulin A
Genotype
Kidney
Mortality
Genes
Glomerular Filtration Rate
Genetic Promoter Regions
Oxidative Stress
Odds Ratio
Confidence Intervals
myristoylmethionine

Keywords

  • Glomerulonephritis
  • Heme oxygenase
  • IGA
  • Renal insufficiency

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality. / Chin, Ho Jun; Cho, Hyun Jin; Lee, Tae Woo; Na, Ki Young; Yoon, Hyung Jin; Chae, Dong Wan; Kim, Suhnggwon; Jeon, Un Sil; Do, Jun Young; Park, Jong Won; Yoon, Kyung Woo; Shin, Young Tai; Lee, Kang Wook; Na, Ki Ryang; Cha, Dae-Ryong; Kang, Young Sun; Jang, Eun Hee; Kim, Won; Kim, Nam Ho; Bae, Woo Kyun; Kim, Hye Young; Ahn, Ki Sung; Cho, Jong Tae; Lee, Eun Kyeong; Kim, Ki Hyun; An, Won Suk; Kim, Seong Eun; Bog, Choi Gyu; Kim, Seung Jung; Chung, Woo Kyung; Lee, Hyun Hee; Yang, Jaeseok; Kim, Sejoong; Chang, Se Ho; Noh, Jung Woo; Lee, Young Ki; Kim, Seong Gyun; Oh, Jieun; Song, Young Rim; Kim, Moon Jae; Lee, Seoung Woo; Kim, Yeong Hoon; Park, Won Do; Kim, Hyun Chul; Park, Sung Bae; Kim, Kyo Soon; Cho, Won Yong; Kim, Hyoung Kyu; Jo, Sang Kyung; Ryong, Cha Dae; Sun, Kang Young; Kwon, Young-Joo; Kim, Yong Lim; Park, Sun Hee; Kim, Chan Duck; Yang, Dong Ho; Kwak, Ihm Soo; Lee, Soo Bong; Lee, Dong Won; Song, Sang Heon; Seoung, Eun Young; Yoon, Su Jin; Lim, Chun Soo; Oh, Yoon Kyu; Oh, Kook Hwan; Joo, Kwon Wook; Kim, Yon Su; Ahn, Curie; Han, Jin Suk; Lee, Kyu Beck; Kim, Yoon Goo; Lee, Jung Eun; Lee, Sang Koo.

In: Journal of Korean Medical Science, Vol. 24, No. SUPPL.1, 01.01.2009.

Research output: Contribution to journalArticle

Chin, HJ, Cho, HJ, Lee, TW, Na, KY, Yoon, HJ, Chae, DW, Kim, S, Jeon, US, Do, JY, Park, JW, Yoon, KW, Shin, YT, Lee, KW, Na, KR, Cha, D-R, Kang, YS, Jang, EH, Kim, W, Kim, NH, Bae, WK, Kim, HY, Ahn, KS, Cho, JT, Lee, EK, Kim, KH, An, WS, Kim, SE, Bog, CG, Kim, SJ, Chung, WK, Lee, HH, Yang, J, Kim, S, Chang, SH, Noh, JW, Lee, YK, Kim, SG, Oh, J, Song, YR, Kim, MJ, Lee, SW, Kim, YH, Park, WD, Kim, HC, Park, SB, Kim, KS, Cho, WY, Kim, HK, Jo, SK, Ryong, CD, Sun, KY, Kwon, Y-J, Kim, YL, Park, SH, Kim, CD, Yang, DH, Kwak, IS, Lee, SB, Lee, DW, Song, SH, Seoung, EY, Yoon, SJ, Lim, CS, Oh, YK, Oh, KH, Joo, KW, Kim, YS, Ahn, C, Han, JS, Lee, KB, Kim, YG, Lee, JE & Lee, SK 2009, 'The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality', Journal of Korean Medical Science, vol. 24, no. SUPPL.1. https://doi.org/10.3346/jkms.2009.24.S1.S30
Chin, Ho Jun ; Cho, Hyun Jin ; Lee, Tae Woo ; Na, Ki Young ; Yoon, Hyung Jin ; Chae, Dong Wan ; Kim, Suhnggwon ; Jeon, Un Sil ; Do, Jun Young ; Park, Jong Won ; Yoon, Kyung Woo ; Shin, Young Tai ; Lee, Kang Wook ; Na, Ki Ryang ; Cha, Dae-Ryong ; Kang, Young Sun ; Jang, Eun Hee ; Kim, Won ; Kim, Nam Ho ; Bae, Woo Kyun ; Kim, Hye Young ; Ahn, Ki Sung ; Cho, Jong Tae ; Lee, Eun Kyeong ; Kim, Ki Hyun ; An, Won Suk ; Kim, Seong Eun ; Bog, Choi Gyu ; Kim, Seung Jung ; Chung, Woo Kyung ; Lee, Hyun Hee ; Yang, Jaeseok ; Kim, Sejoong ; Chang, Se Ho ; Noh, Jung Woo ; Lee, Young Ki ; Kim, Seong Gyun ; Oh, Jieun ; Song, Young Rim ; Kim, Moon Jae ; Lee, Seoung Woo ; Kim, Yeong Hoon ; Park, Won Do ; Kim, Hyun Chul ; Park, Sung Bae ; Kim, Kyo Soon ; Cho, Won Yong ; Kim, Hyoung Kyu ; Jo, Sang Kyung ; Ryong, Cha Dae ; Sun, Kang Young ; Kwon, Young-Joo ; Kim, Yong Lim ; Park, Sun Hee ; Kim, Chan Duck ; Yang, Dong Ho ; Kwak, Ihm Soo ; Lee, Soo Bong ; Lee, Dong Won ; Song, Sang Heon ; Seoung, Eun Young ; Yoon, Su Jin ; Lim, Chun Soo ; Oh, Yoon Kyu ; Oh, Kook Hwan ; Joo, Kwon Wook ; Kim, Yon Su ; Ahn, Curie ; Han, Jin Suk ; Lee, Kyu Beck ; Kim, Yoon Goo ; Lee, Jung Eun ; Lee, Sang Koo. / The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality. In: Journal of Korean Medical Science. 2009 ; Vol. 24, No. SUPPL.1.
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title = "The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality",
abstract = "The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 at diagnosis. The short (S: <23), medium (M: 23-28), and long (L: >28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2{\%}, 6.9{\%}, 3.1{\%}, 30.8{\%}, 22.7{\%}, and 29.4{\%}, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2{\%}, which was lower than 32.2{\%} in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95{\%} confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients.",
keywords = "Glomerulonephritis, Heme oxygenase, IGA, Renal insufficiency",
author = "Chin, {Ho Jun} and Cho, {Hyun Jin} and Lee, {Tae Woo} and Na, {Ki Young} and Yoon, {Hyung Jin} and Chae, {Dong Wan} and Suhnggwon Kim and Jeon, {Un Sil} and Do, {Jun Young} and Park, {Jong Won} and Yoon, {Kyung Woo} and Shin, {Young Tai} and Lee, {Kang Wook} and Na, {Ki Ryang} and Dae-Ryong Cha and Kang, {Young Sun} and Jang, {Eun Hee} and Won Kim and Kim, {Nam Ho} and Bae, {Woo Kyun} and Kim, {Hye Young} and Ahn, {Ki Sung} and Cho, {Jong Tae} and Lee, {Eun Kyeong} and Kim, {Ki Hyun} and An, {Won Suk} and Kim, {Seong Eun} and Bog, {Choi Gyu} and Kim, {Seung Jung} and Chung, {Woo Kyung} and Lee, {Hyun Hee} and Jaeseok Yang and Sejoong Kim and Chang, {Se Ho} and Noh, {Jung Woo} and Lee, {Young Ki} and Kim, {Seong Gyun} and Jieun Oh and Song, {Young Rim} and Kim, {Moon Jae} and Lee, {Seoung Woo} and Kim, {Yeong Hoon} and Park, {Won Do} and Kim, {Hyun Chul} and Park, {Sung Bae} and Kim, {Kyo Soon} and Cho, {Won Yong} and Kim, {Hyoung Kyu} and Jo, {Sang Kyung} and Ryong, {Cha Dae} and Sun, {Kang Young} and Young-Joo Kwon and Kim, {Yong Lim} and Park, {Sun Hee} and Kim, {Chan Duck} and Yang, {Dong Ho} and Kwak, {Ihm Soo} and Lee, {Soo Bong} and Lee, {Dong Won} and Song, {Sang Heon} and Seoung, {Eun Young} and Yoon, {Su Jin} and Lim, {Chun Soo} and Oh, {Yoon Kyu} and Oh, {Kook Hwan} and Joo, {Kwon Wook} and Kim, {Yon Su} and Curie Ahn and Han, {Jin Suk} and Lee, {Kyu Beck} and Kim, {Yoon Goo} and Lee, {Jung Eun} and Lee, {Sang Koo}",
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doi = "10.3346/jkms.2009.24.S1.S30",
language = "English",
volume = "24",
journal = "Journal of Korean Medical Science",
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T1 - The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality

AU - Chin, Ho Jun

AU - Cho, Hyun Jin

AU - Lee, Tae Woo

AU - Na, Ki Young

AU - Yoon, Hyung Jin

AU - Chae, Dong Wan

AU - Kim, Suhnggwon

AU - Jeon, Un Sil

AU - Do, Jun Young

AU - Park, Jong Won

AU - Yoon, Kyung Woo

AU - Shin, Young Tai

AU - Lee, Kang Wook

AU - Na, Ki Ryang

AU - Cha, Dae-Ryong

AU - Kang, Young Sun

AU - Jang, Eun Hee

AU - Kim, Won

AU - Kim, Nam Ho

AU - Bae, Woo Kyun

AU - Kim, Hye Young

AU - Ahn, Ki Sung

AU - Cho, Jong Tae

AU - Lee, Eun Kyeong

AU - Kim, Ki Hyun

AU - An, Won Suk

AU - Kim, Seong Eun

AU - Bog, Choi Gyu

AU - Kim, Seung Jung

AU - Chung, Woo Kyung

AU - Lee, Hyun Hee

AU - Yang, Jaeseok

AU - Kim, Sejoong

AU - Chang, Se Ho

AU - Noh, Jung Woo

AU - Lee, Young Ki

AU - Kim, Seong Gyun

AU - Oh, Jieun

AU - Song, Young Rim

AU - Kim, Moon Jae

AU - Lee, Seoung Woo

AU - Kim, Yeong Hoon

AU - Park, Won Do

AU - Kim, Hyun Chul

AU - Park, Sung Bae

AU - Kim, Kyo Soon

AU - Cho, Won Yong

AU - Kim, Hyoung Kyu

AU - Jo, Sang Kyung

AU - Ryong, Cha Dae

AU - Sun, Kang Young

AU - Kwon, Young-Joo

AU - Kim, Yong Lim

AU - Park, Sun Hee

AU - Kim, Chan Duck

AU - Yang, Dong Ho

AU - Kwak, Ihm Soo

AU - Lee, Soo Bong

AU - Lee, Dong Won

AU - Song, Sang Heon

AU - Seoung, Eun Young

AU - Yoon, Su Jin

AU - Lim, Chun Soo

AU - Oh, Yoon Kyu

AU - Oh, Kook Hwan

AU - Joo, Kwon Wook

AU - Kim, Yon Su

AU - Ahn, Curie

AU - Han, Jin Suk

AU - Lee, Kyu Beck

AU - Kim, Yoon Goo

AU - Lee, Jung Eun

AU - Lee, Sang Koo

PY - 2009/1/1

Y1 - 2009/1/1

N2 - The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 at diagnosis. The short (S: <23), medium (M: 23-28), and long (L: >28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients.

AB - The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 at diagnosis. The short (S: <23), medium (M: 23-28), and long (L: >28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients.

KW - Glomerulonephritis

KW - Heme oxygenase

KW - IGA

KW - Renal insufficiency

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JO - Journal of Korean Medical Science

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SN - 1011-8934

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