The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality

Ho Jun Chin, Hyun Jin Cho, Tae Woo Lee, Ki Young Na, Hyung Jin Yoon, Dong Wan Chae, Suhnggwon Kim, Un Sil Jeon, Jun Young Do, Jong Won Park, Kyung Woo Yoon, Young Tai Shin, Kang Wook Lee, Ki Ryang Na, Dae Ryong Cha, Young Sun Kang, Eun Hee Jang, Won Kim, Nam Ho Kim, Woo Kyun BaeHye Young Kim, Ki Sung Ahn, Jong Tae Cho, Eun Kyeong Lee, Ki Hyun Kim, Won Suk An, Seong Eun Kim, Choi Gyu Bog, Seung Jung Kim, Woo Kyung Chung, Hyun Hee Lee, Jaeseok Yang, Sejoong Kim, Se Ho Chang, Jung Woo Noh, Young Ki Lee, Seong Gyun Kim, Jieun Oh, Young Rim Song, Moon Jae Kim, Seoung Woo Lee, Yeong Hoon Kim, Won Do Park, Hyun Chul Kim, Sung Bae Park, Kyo Soon Kim, Won Yong Cho, Hyoung Kyu Kim, Sang Kyung Jo, Cha Dae Ryong, Kang Young Sun, Young Joo Kwon, Yong Lim Kim, Sun Hee Park, Chan Duck Kim, Dong Ho Yang, Ihm Soo Kwak, Soo Bong Lee, Dong Won Lee, Sang Heon Song, Eun Young Seoung, Su Jin Yoon, Chun Soo Lim, Yoon Kyu Oh, Kook Hwan Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn, Jin Suk Han, Kyu Beck Lee, Yoon Goo Kim, Jung Eun Lee, Sang Koo Lee

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Abstract

The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 at diagnosis. The short (S: <23), medium (M: 23-28), and long (L: >28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients.

Original languageEnglish
Pages (from-to)S30-S37
JournalJournal of Korean medical science
Volume24
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2009

Keywords

  • Glomerulonephritis
  • Heme oxygenase
  • IGA
  • Renal insufficiency

ASJC Scopus subject areas

  • Medicine(all)

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    Chin, H. J., Cho, H. J., Lee, T. W., Na, K. Y., Yoon, H. J., Chae, D. W., Kim, S., Jeon, U. S., Do, J. Y., Park, J. W., Yoon, K. W., Shin, Y. T., Lee, K. W., Na, K. R., Cha, D. R., Kang, Y. S., Jang, E. H., Kim, W., Kim, N. H., ... Lee, S. K. (2009). The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality. Journal of Korean medical science, 24(SUPPL.1), S30-S37. https://doi.org/10.3346/jkms.2009.24.S1.S30