The Highly Evolvable Antibody Fc Domain

Hye In Park, Hyun Woung Yoon, Sang Taek Jung

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)


The Fc region of the IgG antibody recruits immune leukocytes or serum complement molecules, which in turn triggers the clearance of defective cells such as tumor cells or infected cells. In addition, the Fc region is crucial for the prolonged serum persistence of circulating IgG antibodies through an intracellular trafficking and recycling mechanism. Recently, the utility of antibody Fc has been further expanded to include a new class of antigen-binding scaffolds. This review presents the recent progress in the field of antibody Fc engineering and highlights new biomolecular, cellular, and evolutionary approaches to overcome the limitations of conventional monoclonal therapeutic antibodies by engineering the antibody Fc domain.

Original languageEnglish
Pages (from-to)895-908
Number of pages14
JournalTrends in Biotechnology
Issue number11
Publication statusPublished - 2016 Nov 1
Externally publishedYes


  • antibody engineering
  • antibody Fc
  • effector functions
  • serum half-life

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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