The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma

Jeong Hee Choi, Kyung Wha Lee, Cheol Woo Kim, Choon Sik Park, Hyun Young Lee, Gyu Young Hur, Seung Hyun Kim, Chein Soo Hong, An Soo Jang, Hae Sim Park

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    25 Citations (Scopus)

    Abstract

    Background: Although the pathogenesis of toluene diisocyanate (TDI)-induced occupational asthma (TDI-OA) is incompletely understood, several studies have suggested immunologic mechanisms, including specific IgE responses. A few studies have suggested human leukocyte antigen (HLA) associations with TDI-induced asthma in Western countries, but this is the first investigation of associations between HLA class I and II alleles and TDI-induced asthma patients in Asia, using high-resolution analysis. Methods: Patients with TDI-OA (n = 84), asymptomatic exposed controls (AECs, n = 47) and unexposed normal controls (NCs, n = 127) were enrolled. HLA class I and II genotyping was performed by the direct DNA sequencing analysis. Specific serum IgE antibodies to the vapor type TDI-albumin conjugate were measured by ELISA. Results: There was no significant association between the allele frequencies and the phenotype of TDI-OA. However, the frequency of the HLA DRB1*1501-DQB1*0602- DPB1*0501 haplotype was significantly higher in TDI-OA patients (19%) than in AEC (2.1%, p = 0.007, OR 4.429, CI 1.497-13.103) or NC (3.1%, p < 0.001, OR 7.235, CI 2.236-22.510) subjects, with statistical significance persisting after correction for multiple comparisons. DQB1*0402 was significantly associated with the presence of specific IgE to TDI-albumin conjugates in serum (p = 0.006, OR 4.552, CI 1.540-13.449). This p value remained significant after correction for multiple comparison. Conclusion: The HLA DRB1*1501-DQB1 *0602-DPB1* 0501 haplotype may be a genetic marker for the development of TDI-induced asthma in Koreans. Several HLA alleles that enhance specific IgE sensitization in exposed subjects are indicated.

    Original languageEnglish
    Pages (from-to)156-163
    Number of pages8
    JournalInternational Archives of Allergy and Immunology
    Volume150
    Issue number2
    DOIs
    Publication statusPublished - 2009 Sep

    Keywords

    • Asthma
    • Human leukocyte antigen class
    • Immunoglobulin E
    • Toluene diisocyanate

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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