The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean

Ju Seung Kim, Sung Min Ahn, Young Kul Jung, Young Kul Jung Kwon, Yun Soo Kim, Duck Joo Choi, Ju Hyun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Two variants of the inosine triphosphatase (ITPA: rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in Korean patients treated with pegylated interferon (PEG-IFN) plus ribavirin. Of the 133 patients, 108 were CC and 25 were non-CC at rs1127354 (groups A and B, respectively). On the other hand, at rs7270101 all 133 were AA. The mean values of Hemoglobin (Hgb) after 4, 8, and 12 weeks of treatment in groups A and B were 12.2 and 14.0, 11.8 and 13.2, and 11.5 and 12.9, respectively (P = 0.001, 0.036, 0.036). Sustained virologic response (SVR) was achieved in 67.8% (40/59) of genotype 1 patients and in 75% (27/36) of non-genotype 1 patients. Regarding ITPA variants, SVR was achieved by 66% and 80% of genotype 1 (P = 0.282), and by 78% and 71% (P = 0.726) of non-genotype 1. SVR was not significantly different in groups A and B. In conclusion, non-CC at rs1127354 without involvement of rs7270101 is strongly associated with protection from ribavirin-induced anemia, however, ITPA genotype is not associated with SVR.

Original languageEnglish
Pages (from-to)1213-1219
Number of pages7
JournalJournal of Korean Medical Science
Volume28
Issue number8
DOIs
Publication statusPublished - 2013 Sep 25
Externally publishedYes

Fingerprint

Chronic Hepatitis C
Ribavirin
Hemoglobins
Genotype
Interferons
Anemia
inosine triphosphatase
Sustained Virologic Response
Genes
Therapeutics

Keywords

  • Anemia
  • Chronic
  • Hepatitis C
  • Il28b
  • Itpa
  • Ribavirin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean. / Kim, Ju Seung; Ahn, Sung Min; Jung, Young Kul; Kwon, Young Kul Jung; Kim, Yun Soo; Choi, Duck Joo; Kim, Ju Hyun.

In: Journal of Korean Medical Science, Vol. 28, No. 8, 25.09.2013, p. 1213-1219.

Research output: Contribution to journalArticle

Kim, Ju Seung ; Ahn, Sung Min ; Jung, Young Kul ; Kwon, Young Kul Jung ; Kim, Yun Soo ; Choi, Duck Joo ; Kim, Ju Hyun. / The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean. In: Journal of Korean Medical Science. 2013 ; Vol. 28, No. 8. pp. 1213-1219.
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abstract = "Two variants of the inosine triphosphatase (ITPA: rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in Korean patients treated with pegylated interferon (PEG-IFN) plus ribavirin. Of the 133 patients, 108 were CC and 25 were non-CC at rs1127354 (groups A and B, respectively). On the other hand, at rs7270101 all 133 were AA. The mean values of Hemoglobin (Hgb) after 4, 8, and 12 weeks of treatment in groups A and B were 12.2 and 14.0, 11.8 and 13.2, and 11.5 and 12.9, respectively (P = 0.001, 0.036, 0.036). Sustained virologic response (SVR) was achieved in 67.8{\%} (40/59) of genotype 1 patients and in 75{\%} (27/36) of non-genotype 1 patients. Regarding ITPA variants, SVR was achieved by 66{\%} and 80{\%} of genotype 1 (P = 0.282), and by 78{\%} and 71{\%} (P = 0.726) of non-genotype 1. SVR was not significantly different in groups A and B. In conclusion, non-CC at rs1127354 without involvement of rs7270101 is strongly associated with protection from ribavirin-induced anemia, however, ITPA genotype is not associated with SVR.",
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