The impact of organokines on insulin resistance, inflammation, and atherosclerosis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Immoderate energy intake, a sedentary lifestyle, and aging have contributed to the increased prevalence of obesity, sarcopenia, metabolic syndrome, type 2 diabetes, and cardiovascular disease. There is an urgent need for the development of novel pharmacological interventions that can target excessive fat accumulation and decreased muscle mass and/or strength. Adipokines, bioactive molecules derived from adipose tissue, are involved in the regulation of appetite and satiety, inflammation, energy expenditure, insulin resistance and secretion, glucose and lipid metabolism, and atherosclerosis. Recently, there is emerging evidence that skeletal muscle and the liver also function as endocrine organs that secrete myokines and hepatokines, respectively. Novel discoveries and research into these organokines (adipokines, myokines, and hepatokines) may lead to the development of promising biomarkers and therapeutics for cardiometabolic disease. In this review, I summarize recent data on these organokines and focus on the role of adipokines, myokines, and hepatokines in the regulation of insulin resistance, inflammation, and atherosclerosis.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalEndocrinology and Metabolism
Volume31
Issue number1
DOIs
Publication statusPublished - 2016 Mar 1

Fingerprint

Adipokines
Insulin Resistance
Atherosclerosis
Inflammation
Sarcopenia
Sedentary Lifestyle
Appetite Regulation
Energy Intake
Lipid Metabolism
Type 2 Diabetes Mellitus
Energy Metabolism
Adipose Tissue
Skeletal Muscle
Cardiovascular Diseases
Obesity
Biomarkers
Fats
Pharmacology
Glucose
Muscles

Keywords

  • Adipokines
  • Atherosclerosis
  • Inflammation
  • Insulin resistance

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The impact of organokines on insulin resistance, inflammation, and atherosclerosis. / Choi, Kyung Mook.

In: Endocrinology and Metabolism, Vol. 31, No. 1, 01.03.2016, p. 1-6.

Research output: Contribution to journalArticle

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