The impact of organokines on insulin resistance, inflammation, and atherosclerosis

Kyung Mook Choi

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)

    Abstract

    Immoderate energy intake, a sedentary lifestyle, and aging have contributed to the increased prevalence of obesity, sarcopenia, metabolic syndrome, type 2 diabetes, and cardiovascular disease. There is an urgent need for the development of novel pharmacological interventions that can target excessive fat accumulation and decreased muscle mass and/or strength. Adipokines, bioactive molecules derived from adipose tissue, are involved in the regulation of appetite and satiety, inflammation, energy expenditure, insulin resistance and secretion, glucose and lipid metabolism, and atherosclerosis. Recently, there is emerging evidence that skeletal muscle and the liver also function as endocrine organs that secrete myokines and hepatokines, respectively. Novel discoveries and research into these organokines (adipokines, myokines, and hepatokines) may lead to the development of promising biomarkers and therapeutics for cardiometabolic disease. In this review, I summarize recent data on these organokines and focus on the role of adipokines, myokines, and hepatokines in the regulation of insulin resistance, inflammation, and atherosclerosis.

    Original languageEnglish
    Pages (from-to)1-6
    Number of pages6
    JournalEndocrinology and Metabolism
    Volume31
    Issue number1
    DOIs
    Publication statusPublished - 2016 Mar 1

    Keywords

    • Adipokines
    • Atherosclerosis
    • Inflammation
    • Insulin resistance

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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