The impact of primary tumor location in patients with metastatic colorectal cancer

a Korean Cancer Study Group CO12-04 study

Sang Cheul Oh, Joong Bae Ahn, Sun Young Kim, Jung Hun Kang, Dae Young Zang, Seok Yun Kang, Myoung Joo Kang, Byoung Yong Shim, Sun Kyung Baek, Bong Seog Kim, Kyung Hee Lee, Soon Il Lee, Sang Hee Cho, Byeong Seok Sohn, Samyong Kim, In Gyu Hwang, Eun Mi Nam, Bong Gun Seo, Sang Cheul Oh, Myung Ah Lee & 3 others Sang Cheol Lee, Ji Hyung Hong, Young Suk Park

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND/AIMS: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC). METHODS: Demographic data and clinical information were collected from 1,115 patients from the Republic of Korea, who presented with mCRC between January 2009 and December 2011, using web-based electronic case report forms. Associations between the primary tumor location and the patient's clinical characteristics were assessed, and factors inf luencing overall survival were analyzed using Cox proportional hazards regression models. RESULTS: Of the 1,115 patients recruited to the study, 244 (21.9%) had right colon cancer, 483 (43.3%) had left colon cancer, and 388 (34.8%) had rectal cancer. Liver and lung metastases occurred more frequently in patients with left colon and rectal cancer (p = 0.005 and p = 0.006, respectively), while peritoneal and ovarian metastases occurred more frequently in patients with right and left colon cancer (p < 0.001 and p = 0.031, respectively). The median overall survival of patients with tumors originating in the right colon was significantly shorter than that of patients whose tumors had originated in the left colon or rectum (13.7 months [95% confidence interval (CI), 12.0 to 15.5] vs. 18.0 months [95% CI, 16.3 to 19.7] or 19.9 months [95% CI, 18.5 to 21.3], respectively; p = 0.003). Tumor resection, the number of metastatic sites, and primary tumor location correlated with overall survival in the univariate and multivariate analyses. CONCLUSION: Primary tumor location influences the metastatic sites and prognosis of patients with mCRC.

Original languageEnglish
Pages (from-to)165-177
Number of pages13
JournalThe Korean journal of internal medicine
Volume34
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

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Colorectal Neoplasms
Colonic Neoplasms
Neoplasms
Confidence Intervals
Rectal Neoplasms
Survival
Colon
Neoplasm Metastasis
Republic of Korea
Patient Rights
Proportional Hazards Models
Rectum
Multivariate Analysis
Demography
Lung
Liver

Keywords

  • Colorectal neoplasms
  • Primary tumor location
  • Survival

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The impact of primary tumor location in patients with metastatic colorectal cancer : a Korean Cancer Study Group CO12-04 study. / Oh, Sang Cheul; Ahn, Joong Bae; Kim, Sun Young; Kang, Jung Hun; Zang, Dae Young; Kang, Seok Yun; Kang, Myoung Joo; Shim, Byoung Yong; Baek, Sun Kyung; Kim, Bong Seog; Lee, Kyung Hee; Lee, Soon Il; Cho, Sang Hee; Sohn, Byeong Seok; Kim, Samyong; Hwang, In Gyu; Nam, Eun Mi; Seo, Bong Gun; Oh, Sang Cheul; Lee, Myung Ah; Lee, Sang Cheol; Hong, Ji Hyung; Park, Young Suk.

In: The Korean journal of internal medicine, Vol. 34, No. 1, 01.01.2019, p. 165-177.

Research output: Contribution to journalArticle

Oh, SC, Ahn, JB, Kim, SY, Kang, JH, Zang, DY, Kang, SY, Kang, MJ, Shim, BY, Baek, SK, Kim, BS, Lee, KH, Lee, SI, Cho, SH, Sohn, BS, Kim, S, Hwang, IG, Nam, EM, Seo, BG, Oh, SC, Lee, MA, Lee, SC, Hong, JH & Park, YS 2019, 'The impact of primary tumor location in patients with metastatic colorectal cancer: a Korean Cancer Study Group CO12-04 study', The Korean journal of internal medicine, vol. 34, no. 1, pp. 165-177. https://doi.org/10.3904/kjim.2016.348
Oh, Sang Cheul ; Ahn, Joong Bae ; Kim, Sun Young ; Kang, Jung Hun ; Zang, Dae Young ; Kang, Seok Yun ; Kang, Myoung Joo ; Shim, Byoung Yong ; Baek, Sun Kyung ; Kim, Bong Seog ; Lee, Kyung Hee ; Lee, Soon Il ; Cho, Sang Hee ; Sohn, Byeong Seok ; Kim, Samyong ; Hwang, In Gyu ; Nam, Eun Mi ; Seo, Bong Gun ; Oh, Sang Cheul ; Lee, Myung Ah ; Lee, Sang Cheol ; Hong, Ji Hyung ; Park, Young Suk. / The impact of primary tumor location in patients with metastatic colorectal cancer : a Korean Cancer Study Group CO12-04 study. In: The Korean journal of internal medicine. 2019 ; Vol. 34, No. 1. pp. 165-177.
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T1 - The impact of primary tumor location in patients with metastatic colorectal cancer

T2 - a Korean Cancer Study Group CO12-04 study

AU - Oh, Sang Cheul

AU - Ahn, Joong Bae

AU - Kim, Sun Young

AU - Kang, Jung Hun

AU - Zang, Dae Young

AU - Kang, Seok Yun

AU - Kang, Myoung Joo

AU - Shim, Byoung Yong

AU - Baek, Sun Kyung

AU - Kim, Bong Seog

AU - Lee, Kyung Hee

AU - Lee, Soon Il

AU - Cho, Sang Hee

AU - Sohn, Byeong Seok

AU - Kim, Samyong

AU - Hwang, In Gyu

AU - Nam, Eun Mi

AU - Seo, Bong Gun

AU - Oh, Sang Cheul

AU - Lee, Myung Ah

AU - Lee, Sang Cheol

AU - Hong, Ji Hyung

AU - Park, Young Suk

PY - 2019/1/1

Y1 - 2019/1/1

N2 - BACKGROUND/AIMS: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC). METHODS: Demographic data and clinical information were collected from 1,115 patients from the Republic of Korea, who presented with mCRC between January 2009 and December 2011, using web-based electronic case report forms. Associations between the primary tumor location and the patient's clinical characteristics were assessed, and factors inf luencing overall survival were analyzed using Cox proportional hazards regression models. RESULTS: Of the 1,115 patients recruited to the study, 244 (21.9%) had right colon cancer, 483 (43.3%) had left colon cancer, and 388 (34.8%) had rectal cancer. Liver and lung metastases occurred more frequently in patients with left colon and rectal cancer (p = 0.005 and p = 0.006, respectively), while peritoneal and ovarian metastases occurred more frequently in patients with right and left colon cancer (p < 0.001 and p = 0.031, respectively). The median overall survival of patients with tumors originating in the right colon was significantly shorter than that of patients whose tumors had originated in the left colon or rectum (13.7 months [95% confidence interval (CI), 12.0 to 15.5] vs. 18.0 months [95% CI, 16.3 to 19.7] or 19.9 months [95% CI, 18.5 to 21.3], respectively; p = 0.003). Tumor resection, the number of metastatic sites, and primary tumor location correlated with overall survival in the univariate and multivariate analyses. CONCLUSION: Primary tumor location influences the metastatic sites and prognosis of patients with mCRC.

AB - BACKGROUND/AIMS: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC). METHODS: Demographic data and clinical information were collected from 1,115 patients from the Republic of Korea, who presented with mCRC between January 2009 and December 2011, using web-based electronic case report forms. Associations between the primary tumor location and the patient's clinical characteristics were assessed, and factors inf luencing overall survival were analyzed using Cox proportional hazards regression models. RESULTS: Of the 1,115 patients recruited to the study, 244 (21.9%) had right colon cancer, 483 (43.3%) had left colon cancer, and 388 (34.8%) had rectal cancer. Liver and lung metastases occurred more frequently in patients with left colon and rectal cancer (p = 0.005 and p = 0.006, respectively), while peritoneal and ovarian metastases occurred more frequently in patients with right and left colon cancer (p < 0.001 and p = 0.031, respectively). The median overall survival of patients with tumors originating in the right colon was significantly shorter than that of patients whose tumors had originated in the left colon or rectum (13.7 months [95% confidence interval (CI), 12.0 to 15.5] vs. 18.0 months [95% CI, 16.3 to 19.7] or 19.9 months [95% CI, 18.5 to 21.3], respectively; p = 0.003). Tumor resection, the number of metastatic sites, and primary tumor location correlated with overall survival in the univariate and multivariate analyses. CONCLUSION: Primary tumor location influences the metastatic sites and prognosis of patients with mCRC.

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KW - Primary tumor location

KW - Survival

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