Abstract
BACKGROUND/AIMS: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC). METHODS: Demographic data and clinical information were collected from 1,115 patients from the Republic of Korea, who presented with mCRC between January 2009 and December 2011, using web-based electronic case report forms. Associations between the primary tumor location and the patient's clinical characteristics were assessed, and factors inf luencing overall survival were analyzed using Cox proportional hazards regression models. RESULTS: Of the 1,115 patients recruited to the study, 244 (21.9%) had right colon cancer, 483 (43.3%) had left colon cancer, and 388 (34.8%) had rectal cancer. Liver and lung metastases occurred more frequently in patients with left colon and rectal cancer (p = 0.005 and p = 0.006, respectively), while peritoneal and ovarian metastases occurred more frequently in patients with right and left colon cancer (p < 0.001 and p = 0.031, respectively). The median overall survival of patients with tumors originating in the right colon was significantly shorter than that of patients whose tumors had originated in the left colon or rectum (13.7 months [95% confidence interval (CI), 12.0 to 15.5] vs. 18.0 months [95% CI, 16.3 to 19.7] or 19.9 months [95% CI, 18.5 to 21.3], respectively; p = 0.003). Tumor resection, the number of metastatic sites, and primary tumor location correlated with overall survival in the univariate and multivariate analyses. CONCLUSION: Primary tumor location influences the metastatic sites and prognosis of patients with mCRC.
| Original language | English |
|---|---|
| Pages (from-to) | 165-177 |
| Number of pages | 13 |
| Journal | The Korean journal of internal medicine |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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Keywords
- Colorectal neoplasms
- Primary tumor location
- Survival
ASJC Scopus subject areas
- Internal Medicine
Cite this
The impact of primary tumor location in patients with metastatic colorectal cancer : a Korean Cancer Study Group CO12-04 study. / Oh, Sang Cheul; Ahn, Joong Bae; Kim, Sun Young; Kang, Jung Hun; Zang, Dae Young; Kang, Seok Yun; Kang, Myoung Joo; Shim, Byoung Yong; Baek, Sun Kyung; Kim, Bong Seog; Lee, Kyung Hee; Lee, Soon Il; Cho, Sang Hee; Sohn, Byeong Seok; Kim, Samyong; Hwang, In Gyu; Nam, Eun Mi; Seo, Bong Gun; Oh, Sang Cheul; Lee, Myung Ah; Lee, Sang Cheol; Hong, Ji Hyung; Park, Young Suk.
In: The Korean journal of internal medicine, Vol. 34, No. 1, 01.01.2019, p. 165-177.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The impact of primary tumor location in patients with metastatic colorectal cancer
T2 - a Korean Cancer Study Group CO12-04 study
AU - Oh, Sang Cheul
AU - Ahn, Joong Bae
AU - Kim, Sun Young
AU - Kang, Jung Hun
AU - Zang, Dae Young
AU - Kang, Seok Yun
AU - Kang, Myoung Joo
AU - Shim, Byoung Yong
AU - Baek, Sun Kyung
AU - Kim, Bong Seog
AU - Lee, Kyung Hee
AU - Lee, Soon Il
AU - Cho, Sang Hee
AU - Sohn, Byeong Seok
AU - Kim, Samyong
AU - Hwang, In Gyu
AU - Nam, Eun Mi
AU - Seo, Bong Gun
AU - Oh, Sang Cheul
AU - Lee, Myung Ah
AU - Lee, Sang Cheol
AU - Hong, Ji Hyung
AU - Park, Young Suk
PY - 2019/1/1
Y1 - 2019/1/1
N2 - BACKGROUND/AIMS: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC). METHODS: Demographic data and clinical information were collected from 1,115 patients from the Republic of Korea, who presented with mCRC between January 2009 and December 2011, using web-based electronic case report forms. Associations between the primary tumor location and the patient's clinical characteristics were assessed, and factors inf luencing overall survival were analyzed using Cox proportional hazards regression models. RESULTS: Of the 1,115 patients recruited to the study, 244 (21.9%) had right colon cancer, 483 (43.3%) had left colon cancer, and 388 (34.8%) had rectal cancer. Liver and lung metastases occurred more frequently in patients with left colon and rectal cancer (p = 0.005 and p = 0.006, respectively), while peritoneal and ovarian metastases occurred more frequently in patients with right and left colon cancer (p < 0.001 and p = 0.031, respectively). The median overall survival of patients with tumors originating in the right colon was significantly shorter than that of patients whose tumors had originated in the left colon or rectum (13.7 months [95% confidence interval (CI), 12.0 to 15.5] vs. 18.0 months [95% CI, 16.3 to 19.7] or 19.9 months [95% CI, 18.5 to 21.3], respectively; p = 0.003). Tumor resection, the number of metastatic sites, and primary tumor location correlated with overall survival in the univariate and multivariate analyses. CONCLUSION: Primary tumor location influences the metastatic sites and prognosis of patients with mCRC.
AB - BACKGROUND/AIMS: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC). METHODS: Demographic data and clinical information were collected from 1,115 patients from the Republic of Korea, who presented with mCRC between January 2009 and December 2011, using web-based electronic case report forms. Associations between the primary tumor location and the patient's clinical characteristics were assessed, and factors inf luencing overall survival were analyzed using Cox proportional hazards regression models. RESULTS: Of the 1,115 patients recruited to the study, 244 (21.9%) had right colon cancer, 483 (43.3%) had left colon cancer, and 388 (34.8%) had rectal cancer. Liver and lung metastases occurred more frequently in patients with left colon and rectal cancer (p = 0.005 and p = 0.006, respectively), while peritoneal and ovarian metastases occurred more frequently in patients with right and left colon cancer (p < 0.001 and p = 0.031, respectively). The median overall survival of patients with tumors originating in the right colon was significantly shorter than that of patients whose tumors had originated in the left colon or rectum (13.7 months [95% confidence interval (CI), 12.0 to 15.5] vs. 18.0 months [95% CI, 16.3 to 19.7] or 19.9 months [95% CI, 18.5 to 21.3], respectively; p = 0.003). Tumor resection, the number of metastatic sites, and primary tumor location correlated with overall survival in the univariate and multivariate analyses. CONCLUSION: Primary tumor location influences the metastatic sites and prognosis of patients with mCRC.
KW - Colorectal neoplasms
KW - Primary tumor location
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85059503252&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059503252&partnerID=8YFLogxK
U2 - 10.3904/kjim.2016.348
DO - 10.3904/kjim.2016.348
M3 - Article
C2 - 29172407
AN - SCOPUS:85059503252
VL - 34
SP - 165
EP - 177
JO - Korean Journal of Internal Medicine
JF - Korean Journal of Internal Medicine
SN - 0494-4712
IS - 1
ER -