The influence of AHI1 variants on the diagnosis and treatment outcome in schizophrenia

Stefano Porcelli, Chi Un Pae, Changsu Han, Soo Jung Lee, Ashwin A. Patkar, Prakash S. Masand, Beatrice Balzarro, Siegfried Alberti, Diana De Ronchi, Alessandro Serretti

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8 Citations (Scopus)

Abstract

The present study aimed to explore whether four single nucleotide polymorphisms (SNPs) within the AHI1 gene could be associated with schizophrenia (SCZ) and whether they could predict the clinical outcomes in SCZ patients treated with antipsychotics. Four hundred twenty-six (426) in-patients with SCZ and 345 controls were genotyped for four AHI1 SNPs (rs11154801, rs7750586, rs9647635 and rs9321501). Baseline and clinical measures for SCZ patients were assessed through the Positive and Negative Syndrome Scale (PANSS). Allelic and genotypic frequencies in SCZ subjects were compared with those of controls using the χ2 statistics. The repeated-measure ANOVA was used for the assessment of treatment outcomes measured by PANSS changes. The case-control analysis did not show any difference in the genotypic distribution of the SNPs, while in the allelic analysis, a weak association was found between the rs9647635 A allele and SCZ. Furthermore, in the haplotype analysis, three haplotypes resulted in being associated with SCZ. On the other hand, two SNPs (rs7750586 and rs9647635) were associated with clinical improvement of negative symptoms in the allelic analysis, although in the genotypic analysis, only trends of association were found for the same SNPs. Our findings suggest a possible influence of AHI1 variants on SCZ susceptibility and antipsychotic response, particularly concerning negative symptomatology. Subsequent well-designed studies would be mandatory to confirm our results due to the methodological shortcomings of the present study.

Original languageEnglish
Pages (from-to)2517-2529
Number of pages13
JournalInternational journal of molecular sciences
Volume16
Issue number2
DOIs
Publication statusPublished - 2015 Jan 22

Keywords

  • AHI1 gene
  • Antipsychotic
  • Polymorphism
  • Response
  • Schizophrenia

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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  • Cite this

    Porcelli, S., Pae, C. U., Han, C., Lee, S. J., Patkar, A. A., Masand, P. S., Balzarro, B., Alberti, S., De Ronchi, D., & Serretti, A. (2015). The influence of AHI1 variants on the diagnosis and treatment outcome in schizophrenia. International journal of molecular sciences, 16(2), 2517-2529. https://doi.org/10.3390/ijms16022517