The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents

José A. Ferreira, Lino Gonçalves, Jahed Naghipoor, Paula de Oliveira, Timon Rabczuk

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.

Original languageEnglish
Pages (from-to)71-83
Number of pages13
JournalMathematical Biosciences
Volume283
DOIs
Publication statusPublished - 2017 Jan 1

Keywords

  • Atherosclerotic plaque
  • Drug eluting stent
  • Numerical simulation
  • Porosity

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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