The influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume and free-to-total PSA ratio

A prospective study

Du Geon Moon, J. W. Yu, Jeong Gu Lee, Je-Jong Kim, S. K. Koh, Jun Cheon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives: To evaluate the influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume (PSAT) and free-to-total PSA ratio (f/tPSA) in detecting prostate cancer in men with intermediate PSA levels of 4.1-10.0 ng/mL. Patients and methods: From March 1997 to June 1999, the f/tPSA and PSAT were measured in 105 patients who underwent ultrasound-guided systemic biopsies and had a PSA level of 4.1-10.0 ng/mL, with an apparently normal prostate on a digital rectal examination. The PSAT and f/tPSA were evaluated in all patients and in subgroups of patients with small (<40 mL) or large (≥40 mL) prostates, using receiver operating characteristic (ROC) curves. Results: Total prostate volume was highly correlated with transition zone volume in all patients and in both subgroups (P<0.001). In all 105 patients, PSAT had a sensitivity of 82% and its use would have avoided the largest number of unnecessary biopsies (87% specificity) at a threshold value of 0.35 ng. In men with small prostates f/tPSA and PSAT had a high sensitivity and specificity, at threshold values of 0.12 and 0.35 ng, respectively. In large prostates the PSAT was superior to f/tPSA in detecting prostate cancer. Conclusions: These results suggest that both f/tPSA and PSAT are useful in detecting prostate cancer in men with small prostates, while PSAT is superior to f/tPSA in detecting prostate cancer in men with large prostates.

Original languageEnglish
Pages (from-to)670-674
Number of pages5
JournalBJU International
Volume86
Issue number6
DOIs
Publication statusPublished - 2000 Oct 26

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Prostate-Specific Antigen
Prostate
Prospective Studies
Prostatic Neoplasms
Biopsy
Digital Rectal Examination
ROC Curve
Sensitivity and Specificity

Keywords

  • Biopsy
  • Detection
  • Free PSA
  • Prostate cancer
  • Prostate volume
  • PSA
  • PSAT

ASJC Scopus subject areas

  • Urology

Cite this

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title = "The influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume and free-to-total PSA ratio: A prospective study",
abstract = "Objectives: To evaluate the influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume (PSAT) and free-to-total PSA ratio (f/tPSA) in detecting prostate cancer in men with intermediate PSA levels of 4.1-10.0 ng/mL. Patients and methods: From March 1997 to June 1999, the f/tPSA and PSAT were measured in 105 patients who underwent ultrasound-guided systemic biopsies and had a PSA level of 4.1-10.0 ng/mL, with an apparently normal prostate on a digital rectal examination. The PSAT and f/tPSA were evaluated in all patients and in subgroups of patients with small (<40 mL) or large (≥40 mL) prostates, using receiver operating characteristic (ROC) curves. Results: Total prostate volume was highly correlated with transition zone volume in all patients and in both subgroups (P<0.001). In all 105 patients, PSAT had a sensitivity of 82{\%} and its use would have avoided the largest number of unnecessary biopsies (87{\%} specificity) at a threshold value of 0.35 ng. In men with small prostates f/tPSA and PSAT had a high sensitivity and specificity, at threshold values of 0.12 and 0.35 ng, respectively. In large prostates the PSAT was superior to f/tPSA in detecting prostate cancer. Conclusions: These results suggest that both f/tPSA and PSAT are useful in detecting prostate cancer in men with small prostates, while PSAT is superior to f/tPSA in detecting prostate cancer in men with large prostates.",
keywords = "Biopsy, Detection, Free PSA, Prostate cancer, Prostate volume, PSA, PSAT",
author = "Moon, {Du Geon} and Yu, {J. W.} and Lee, {Jeong Gu} and Je-Jong Kim and Koh, {S. K.} and Jun Cheon",
year = "2000",
month = "10",
day = "26",
doi = "10.1046/j.1464-410X.2000.00838.x",
language = "English",
volume = "86",
pages = "670--674",
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T1 - The influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume and free-to-total PSA ratio

T2 - A prospective study

AU - Moon, Du Geon

AU - Yu, J. W.

AU - Lee, Jeong Gu

AU - Kim, Je-Jong

AU - Koh, S. K.

AU - Cheon, Jun

PY - 2000/10/26

Y1 - 2000/10/26

N2 - Objectives: To evaluate the influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume (PSAT) and free-to-total PSA ratio (f/tPSA) in detecting prostate cancer in men with intermediate PSA levels of 4.1-10.0 ng/mL. Patients and methods: From March 1997 to June 1999, the f/tPSA and PSAT were measured in 105 patients who underwent ultrasound-guided systemic biopsies and had a PSA level of 4.1-10.0 ng/mL, with an apparently normal prostate on a digital rectal examination. The PSAT and f/tPSA were evaluated in all patients and in subgroups of patients with small (<40 mL) or large (≥40 mL) prostates, using receiver operating characteristic (ROC) curves. Results: Total prostate volume was highly correlated with transition zone volume in all patients and in both subgroups (P<0.001). In all 105 patients, PSAT had a sensitivity of 82% and its use would have avoided the largest number of unnecessary biopsies (87% specificity) at a threshold value of 0.35 ng. In men with small prostates f/tPSA and PSAT had a high sensitivity and specificity, at threshold values of 0.12 and 0.35 ng, respectively. In large prostates the PSAT was superior to f/tPSA in detecting prostate cancer. Conclusions: These results suggest that both f/tPSA and PSAT are useful in detecting prostate cancer in men with small prostates, while PSAT is superior to f/tPSA in detecting prostate cancer in men with large prostates.

AB - Objectives: To evaluate the influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume (PSAT) and free-to-total PSA ratio (f/tPSA) in detecting prostate cancer in men with intermediate PSA levels of 4.1-10.0 ng/mL. Patients and methods: From March 1997 to June 1999, the f/tPSA and PSAT were measured in 105 patients who underwent ultrasound-guided systemic biopsies and had a PSA level of 4.1-10.0 ng/mL, with an apparently normal prostate on a digital rectal examination. The PSAT and f/tPSA were evaluated in all patients and in subgroups of patients with small (<40 mL) or large (≥40 mL) prostates, using receiver operating characteristic (ROC) curves. Results: Total prostate volume was highly correlated with transition zone volume in all patients and in both subgroups (P<0.001). In all 105 patients, PSAT had a sensitivity of 82% and its use would have avoided the largest number of unnecessary biopsies (87% specificity) at a threshold value of 0.35 ng. In men with small prostates f/tPSA and PSAT had a high sensitivity and specificity, at threshold values of 0.12 and 0.35 ng, respectively. In large prostates the PSAT was superior to f/tPSA in detecting prostate cancer. Conclusions: These results suggest that both f/tPSA and PSAT are useful in detecting prostate cancer in men with small prostates, while PSAT is superior to f/tPSA in detecting prostate cancer in men with large prostates.

KW - Biopsy

KW - Detection

KW - Free PSA

KW - Prostate cancer

KW - Prostate volume

KW - PSA

KW - PSAT

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DO - 10.1046/j.1464-410X.2000.00838.x

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SP - 670

EP - 674

JO - BJU International

JF - BJU International

SN - 1464-4096

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