Abstract
Objectives: To evaluate the influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume (PSAT) and free-to-total PSA ratio (f/tPSA) in detecting prostate cancer in men with intermediate PSA levels of 4.1-10.0 ng/mL. Patients and methods: From March 1997 to June 1999, the f/tPSA and PSAT were measured in 105 patients who underwent ultrasound-guided systemic biopsies and had a PSA level of 4.1-10.0 ng/mL, with an apparently normal prostate on a digital rectal examination. The PSAT and f/tPSA were evaluated in all patients and in subgroups of patients with small (<40 mL) or large (≥40 mL) prostates, using receiver operating characteristic (ROC) curves. Results: Total prostate volume was highly correlated with transition zone volume in all patients and in both subgroups (P<0.001). In all 105 patients, PSAT had a sensitivity of 82% and its use would have avoided the largest number of unnecessary biopsies (87% specificity) at a threshold value of 0.35 ng. In men with small prostates f/tPSA and PSAT had a high sensitivity and specificity, at threshold values of 0.12 and 0.35 ng, respectively. In large prostates the PSAT was superior to f/tPSA in detecting prostate cancer. Conclusions: These results suggest that both f/tPSA and PSAT are useful in detecting prostate cancer in men with small prostates, while PSAT is superior to f/tPSA in detecting prostate cancer in men with large prostates.
| Original language | English |
|---|---|
| Pages (from-to) | 670-674 |
| Number of pages | 5 |
| Journal | BJU International |
| Volume | 86 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2000 Oct 26 |
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Keywords
- Biopsy
- Detection
- Free PSA
- Prostate cancer
- Prostate volume
- PSA
- PSAT
ASJC Scopus subject areas
- Urology
Cite this
The influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume and free-to-total PSA ratio : A prospective study. / Moon, Du Geon; Yu, J. W.; Lee, Jeong Gu; Kim, Je-Jong; Koh, S. K.; Cheon, Jun.
In: BJU International, Vol. 86, No. 6, 26.10.2000, p. 670-674.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume and free-to-total PSA ratio
T2 - A prospective study
AU - Moon, Du Geon
AU - Yu, J. W.
AU - Lee, Jeong Gu
AU - Kim, Je-Jong
AU - Koh, S. K.
AU - Cheon, Jun
PY - 2000/10/26
Y1 - 2000/10/26
N2 - Objectives: To evaluate the influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume (PSAT) and free-to-total PSA ratio (f/tPSA) in detecting prostate cancer in men with intermediate PSA levels of 4.1-10.0 ng/mL. Patients and methods: From March 1997 to June 1999, the f/tPSA and PSAT were measured in 105 patients who underwent ultrasound-guided systemic biopsies and had a PSA level of 4.1-10.0 ng/mL, with an apparently normal prostate on a digital rectal examination. The PSAT and f/tPSA were evaluated in all patients and in subgroups of patients with small (<40 mL) or large (≥40 mL) prostates, using receiver operating characteristic (ROC) curves. Results: Total prostate volume was highly correlated with transition zone volume in all patients and in both subgroups (P<0.001). In all 105 patients, PSAT had a sensitivity of 82% and its use would have avoided the largest number of unnecessary biopsies (87% specificity) at a threshold value of 0.35 ng. In men with small prostates f/tPSA and PSAT had a high sensitivity and specificity, at threshold values of 0.12 and 0.35 ng, respectively. In large prostates the PSAT was superior to f/tPSA in detecting prostate cancer. Conclusions: These results suggest that both f/tPSA and PSAT are useful in detecting prostate cancer in men with small prostates, while PSAT is superior to f/tPSA in detecting prostate cancer in men with large prostates.
AB - Objectives: To evaluate the influence of prostate volume on the prostate-specific antigen (PSA) level adjusted for the transition zone volume (PSAT) and free-to-total PSA ratio (f/tPSA) in detecting prostate cancer in men with intermediate PSA levels of 4.1-10.0 ng/mL. Patients and methods: From March 1997 to June 1999, the f/tPSA and PSAT were measured in 105 patients who underwent ultrasound-guided systemic biopsies and had a PSA level of 4.1-10.0 ng/mL, with an apparently normal prostate on a digital rectal examination. The PSAT and f/tPSA were evaluated in all patients and in subgroups of patients with small (<40 mL) or large (≥40 mL) prostates, using receiver operating characteristic (ROC) curves. Results: Total prostate volume was highly correlated with transition zone volume in all patients and in both subgroups (P<0.001). In all 105 patients, PSAT had a sensitivity of 82% and its use would have avoided the largest number of unnecessary biopsies (87% specificity) at a threshold value of 0.35 ng. In men with small prostates f/tPSA and PSAT had a high sensitivity and specificity, at threshold values of 0.12 and 0.35 ng, respectively. In large prostates the PSAT was superior to f/tPSA in detecting prostate cancer. Conclusions: These results suggest that both f/tPSA and PSAT are useful in detecting prostate cancer in men with small prostates, while PSAT is superior to f/tPSA in detecting prostate cancer in men with large prostates.
KW - Biopsy
KW - Detection
KW - Free PSA
KW - Prostate cancer
KW - Prostate volume
KW - PSA
KW - PSAT
UR - http://www.scopus.com/inward/record.url?scp=0033780377&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033780377&partnerID=8YFLogxK
U2 - 10.1046/j.1464-410X.2000.00838.x
DO - 10.1046/j.1464-410X.2000.00838.x
M3 - Article
VL - 86
SP - 670
EP - 674
JO - BJU International
JF - BJU International
SN - 1464-4096
IS - 6
ER -