Abstract
Introduction: The purpose of this study was to examine whether the insertion (I) and deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) confers susceptibility to schizophrenia and Parkinsons disease (PD). Materials and methods: A meta-analysis was performed of the associations between the ACE I/D polymorphism and schizophrenia and PD. Results: Thirteen studies with 2024 cases and 2230 controls comprising eight studies on schizophrenia and five on PD were included in the meta-analysis. The meta-analysis revealed no association between the ACE D allele and schizophrenia (OR = 0.990, 95% CI = 0.8891.102, p = 0.856) or PD (OR = 1.067, 95% CI = 0.9071.255, p = 0.433). Stratification by ethnicity indicated no association between the ACE D allele and schizophrenia in European, Asian, or Turkish ethnic groups (OR = 0.896, 95% CI = 0.5661.419, p = 0.640; OR = 1.057, 95% CI = 0.9031.238, p = 0.492; OR = 1.111, 95% CI = 0.8891.389, p = 0.354, respectively). Ethnicity-specific meta-analysis was not conducted for PD because only one ethnic PD study was available. Conclusions: This meta-analysis found no association between the ACE I/D polymorphism and schizophrenia or PD.
| Original language | English |
|---|---|
| Pages (from-to) | 434-442 |
| Number of pages | 9 |
| Journal | JRAAS - Journal of the Renin-Angiotensin-Aldosterone System |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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Keywords
- Angiotensin-converting enzyme
- meta-analysis
- Parkinson's disease
- polymorphism
- schizophrenia
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology
Cite this
The insertion/deletion polymorphism in the angiotensin-converting enzyme and susceptibility to schizophrenia or Parkinson's disease : A meta-analysis. / Song, Gwan Gyu; Lee, Young Ho.
In: JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, Vol. 16, No. 2, 01.01.2015, p. 434-442.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The insertion/deletion polymorphism in the angiotensin-converting enzyme and susceptibility to schizophrenia or Parkinson's disease
T2 - A meta-analysis
AU - Song, Gwan Gyu
AU - Lee, Young Ho
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Introduction: The purpose of this study was to examine whether the insertion (I) and deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) confers susceptibility to schizophrenia and Parkinsons disease (PD). Materials and methods: A meta-analysis was performed of the associations between the ACE I/D polymorphism and schizophrenia and PD. Results: Thirteen studies with 2024 cases and 2230 controls comprising eight studies on schizophrenia and five on PD were included in the meta-analysis. The meta-analysis revealed no association between the ACE D allele and schizophrenia (OR = 0.990, 95% CI = 0.8891.102, p = 0.856) or PD (OR = 1.067, 95% CI = 0.9071.255, p = 0.433). Stratification by ethnicity indicated no association between the ACE D allele and schizophrenia in European, Asian, or Turkish ethnic groups (OR = 0.896, 95% CI = 0.5661.419, p = 0.640; OR = 1.057, 95% CI = 0.9031.238, p = 0.492; OR = 1.111, 95% CI = 0.8891.389, p = 0.354, respectively). Ethnicity-specific meta-analysis was not conducted for PD because only one ethnic PD study was available. Conclusions: This meta-analysis found no association between the ACE I/D polymorphism and schizophrenia or PD.
AB - Introduction: The purpose of this study was to examine whether the insertion (I) and deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) confers susceptibility to schizophrenia and Parkinsons disease (PD). Materials and methods: A meta-analysis was performed of the associations between the ACE I/D polymorphism and schizophrenia and PD. Results: Thirteen studies with 2024 cases and 2230 controls comprising eight studies on schizophrenia and five on PD were included in the meta-analysis. The meta-analysis revealed no association between the ACE D allele and schizophrenia (OR = 0.990, 95% CI = 0.8891.102, p = 0.856) or PD (OR = 1.067, 95% CI = 0.9071.255, p = 0.433). Stratification by ethnicity indicated no association between the ACE D allele and schizophrenia in European, Asian, or Turkish ethnic groups (OR = 0.896, 95% CI = 0.5661.419, p = 0.640; OR = 1.057, 95% CI = 0.9031.238, p = 0.492; OR = 1.111, 95% CI = 0.8891.389, p = 0.354, respectively). Ethnicity-specific meta-analysis was not conducted for PD because only one ethnic PD study was available. Conclusions: This meta-analysis found no association between the ACE I/D polymorphism and schizophrenia or PD.
KW - Angiotensin-converting enzyme
KW - meta-analysis
KW - Parkinson's disease
KW - polymorphism
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=84930888371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930888371&partnerID=8YFLogxK
U2 - 10.1177/1470320313495909
DO - 10.1177/1470320313495909
M3 - Article
C2 - 25143327
AN - SCOPUS:84930888371
VL - 16
SP - 434
EP - 442
JO - JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
JF - JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
SN - 1470-3203
IS - 2
ER -