The interaction between ischemia-reperfusion and immune responses in the kidney

Hye Ryoun Jang, Gang Jee Ko, Barbara A. Wasowska, Hamid Rabb

Research output: Contribution to journalReview article

125 Citations (Scopus)

Abstract

Kidney ischemia-reperfusion injury (IRI) engages both the innate and adaptive immune responses. Cellular mediators of immunity, such as dendritic cells, neutrophils, macrophages, natural killer T, T, and B cells, contribute to the pathogenesis of renal injury after IRI. Postischemic kidneys express increased levels of adhesion molecules on endothelial cells and toll-like receptors on tubular epithelial cells. Soluble components of the immune system, such as complement activation proteins and cytokines, also participate in injury/repair of postischemic kidneys. Experimental studies on the immune response in kidney IRI have resulted in better understanding of the mechanisms underlying IRI and led to the discovery of novel therapeutic and diagnostic targets.

Original languageEnglish
Pages (from-to)859-864
Number of pages6
JournalJournal of Molecular Medicine
Volume87
Issue number9
DOIs
Publication statusPublished - 2009 Sep 1
Externally publishedYes

Fingerprint

Reperfusion
Reperfusion Injury
Ischemia
Kidney
Natural Killer T-Cells
Complement Activation
Toll-Like Receptors
Wounds and Injuries
Adaptive Immunity
Innate Immunity
Cellular Immunity
Dendritic Cells
Immune System
Complement System Proteins
Neutrophils
B-Lymphocytes
Endothelial Cells
Epithelial Cells
Macrophages
Cytokines

Keywords

  • Immune response
  • Inflammation
  • Ischemia-reperfusion injury

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

Cite this

The interaction between ischemia-reperfusion and immune responses in the kidney. / Jang, Hye Ryoun; Ko, Gang Jee; Wasowska, Barbara A.; Rabb, Hamid.

In: Journal of Molecular Medicine, Vol. 87, No. 9, 01.09.2009, p. 859-864.

Research output: Contribution to journalReview article

Jang, Hye Ryoun ; Ko, Gang Jee ; Wasowska, Barbara A. ; Rabb, Hamid. / The interaction between ischemia-reperfusion and immune responses in the kidney. In: Journal of Molecular Medicine. 2009 ; Vol. 87, No. 9. pp. 859-864.
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