The interaction between ischemia-reperfusion and immune responses in the kidney

Hye Ryoun Jang, Gang Jee Ko, Barbara A. Wasowska, Hamid Rabb

Research output: Contribution to journalReview article

126 Citations (Scopus)

Abstract

Kidney ischemia-reperfusion injury (IRI) engages both the innate and adaptive immune responses. Cellular mediators of immunity, such as dendritic cells, neutrophils, macrophages, natural killer T, T, and B cells, contribute to the pathogenesis of renal injury after IRI. Postischemic kidneys express increased levels of adhesion molecules on endothelial cells and toll-like receptors on tubular epithelial cells. Soluble components of the immune system, such as complement activation proteins and cytokines, also participate in injury/repair of postischemic kidneys. Experimental studies on the immune response in kidney IRI have resulted in better understanding of the mechanisms underlying IRI and led to the discovery of novel therapeutic and diagnostic targets.

Original languageEnglish
Pages (from-to)859-864
Number of pages6
JournalJournal of Molecular Medicine
Volume87
Issue number9
DOIs
Publication statusPublished - 2009 Sep 1
Externally publishedYes

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Keywords

  • Immune response
  • Inflammation
  • Ischemia-reperfusion injury

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

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