The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells

Young Yang, Jeong Hyung Lee, Kun Yong Kim, Hyun Keun Song, Jae Kwang Kim, Suk Ran Yoon, Daeho Cho, Kyu Sang Song, Young Ho Lee, Inpyo Choi

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51 Citations (Scopus)

Abstract

As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.

Original languageEnglish
Pages (from-to)191-200
Number of pages10
JournalCancer letters
Volume221
Issue number2
DOIs
Publication statusPublished - 2005 Apr 28
Externally publishedYes

Keywords

  • 9-27
  • IFN-γ
  • Invasion
  • Natural killer cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Yang, Y., Lee, J. H., Kim, K. Y., Song, H. K., Kim, J. K., Yoon, S. R., Cho, D., Song, K. S., Lee, Y. H., & Choi, I. (2005). The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells. Cancer letters, 221(2), 191-200. https://doi.org/10.1016/j.canlet.2004.08.022