The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells

Young Yang; Jeong Hyung Lee; Kun Yong Kim; Hyun Keun Song; Jae Kwang Kim; Suk Ran Yoon; Daeho Cho; Kyu Sang Song; Young Ho Lee; Inpyo Choi

doi:10.1016/j.canlet.2004.08.022

The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells

Young Yang, Jeong Hyung Lee, Kun Yong Kim, Hyun Keun Song, Jae Kwang Kim, Suk Ran Yoon, Daeho Cho, Kyu Sang Song, Young Ho Lee, Inpyo Choi

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.

Original language	English
Pages (from-to)	191-200
Number of pages	10
Journal	Cancer letters
Volume	221
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2004.08.022
Publication status	Published - 2005 Apr 28
Externally published	Yes

Keywords

9-27
IFN-γ
Invasion
Natural killer cell

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2004.08.022

Cite this

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title = "The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells",

abstract = "As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.",

keywords = "9-27, IFN-γ, Invasion, Natural killer cell",

author = "Young Yang and Lee, {Jeong Hyung} and Kim, {Kun Yong} and Song, {Hyun Keun} and Kim, {Jae Kwang} and Yoon, {Suk Ran} and Daeho Cho and Song, {Kyu Sang} and Lee, {Young Ho} and Inpyo Choi",

note = "Funding Information: This work was supported by a grant FG-3-1-04 of 21C Frontier Functional Human Genome Project from the Ministry of Science and Technology and Korea Research Foundation grant (KRF-2002-042-E00023). We thank Dr Toshio Kitamura (Department of Hematopoietic Factors, The Institute of Medical Science, University of Tokyo, Japan) for a kind gift of SST vector. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2005",

month = apr,

day = "28",

doi = "10.1016/j.canlet.2004.08.022",

language = "English",

volume = "221",

pages = "191--200",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells

AU - Yang, Young

AU - Lee, Jeong Hyung

AU - Kim, Kun Yong

AU - Song, Hyun Keun

AU - Kim, Jae Kwang

AU - Yoon, Suk Ran

AU - Cho, Daeho

AU - Song, Kyu Sang

AU - Lee, Young Ho

AU - Choi, Inpyo

N1 - Funding Information: This work was supported by a grant FG-3-1-04 of 21C Frontier Functional Human Genome Project from the Ministry of Science and Technology and Korea Research Foundation grant (KRF-2002-042-E00023). We thank Dr Toshio Kitamura (Department of Hematopoietic Factors, The Institute of Medical Science, University of Tokyo, Japan) for a kind gift of SST vector. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2005/4/28

Y1 - 2005/4/28

N2 - As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.

AB - As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.

KW - 9-27

KW - IFN-γ

KW - Invasion

KW - Natural killer cell

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JO - Cancer Letters

JF - Cancer Letters

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The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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