The interrelationship between non-motor symptoms in Atypical Parkinsonism

Chan Nyoung Lee, Minjik Kim, Hye Mi Lee, Ji Wan Jang, Seon Min Lee, Do-Young Kwon, Kun Woo Park, Seong Beom Koh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background Atypical Parkinsonism is less common and has more severe symptoms than Parkinson's disease (PD). Little is known about the non-motor symptom (NMS) characteristics of multiple systemic atrophy (MSA) or progressive supranuclear palsy (PSP). We report the interrelationship of NMS in MSA, PSP, and PD. Methods We studied 117 cases of PD and 57 of Atypical Parkinsonism. Out of the 57 patients, 31 had multiple systemic atrophy parkinsonian subtype (MSA-P), 14 had multiple systemic atrophy cerebellar dysfunction subtype (MSA-C), and 12 had PSP. We assessed the condition of the patients using the United Parkinson's Disease Rating Scale part III (UPDRS-III), the modified Hoehn & Yahr scale (H&Y), the non-motor symptom scale (NMSS), and the Parkinson's Disease Questionnaire (PDQ-39). Results In Atypical Parkinsonism, the NMSS scores significantly correlated with PDQ-39 scores, but not with UPDRS-III. In the MSA-P group, the mood/cognitive domain significantly correlated with both the urinary and sleep/fatigue domains. In the MSA-C group, the sleep/fatigue domain correlated with the mood/cognition and cardiovascular domains. Finally, in the PSP and PD groups, the attention/memory domain significantly correlated with the sleep/fatigue and mood/cognition domains. Discussion These results suggest that, with respect to cognitive function, dysautonomia and sleep/fatigue are detrimental factors in MSA and PSP, respectively.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalJournal of the Neurological Sciences
Volume327
Issue number1-2
DOIs
Publication statusPublished - 2013 Apr 15

Fingerprint

Parkinsonian Disorders
Progressive Supranuclear Palsy
Atrophy
Parkinson Disease
Fatigue
Sleep
Cognition
Primary Dysautonomias
Cerebellar Diseases

Keywords

  • Multiple system atrophy
  • Non-motor symptoms
  • Parkinson's disease
  • Progressive supranuclear palsy
  • Quality of life

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

The interrelationship between non-motor symptoms in Atypical Parkinsonism. / Lee, Chan Nyoung; Kim, Minjik; Lee, Hye Mi; Jang, Ji Wan; Lee, Seon Min; Kwon, Do-Young; Park, Kun Woo; Koh, Seong Beom.

In: Journal of the Neurological Sciences, Vol. 327, No. 1-2, 15.04.2013, p. 15-21.

Research output: Contribution to journalArticle

Lee, Chan Nyoung ; Kim, Minjik ; Lee, Hye Mi ; Jang, Ji Wan ; Lee, Seon Min ; Kwon, Do-Young ; Park, Kun Woo ; Koh, Seong Beom. / The interrelationship between non-motor symptoms in Atypical Parkinsonism. In: Journal of the Neurological Sciences. 2013 ; Vol. 327, No. 1-2. pp. 15-21.
@article{4e22656c80954a1bb71ed8b72b106b32,
title = "The interrelationship between non-motor symptoms in Atypical Parkinsonism",
abstract = "Background Atypical Parkinsonism is less common and has more severe symptoms than Parkinson's disease (PD). Little is known about the non-motor symptom (NMS) characteristics of multiple systemic atrophy (MSA) or progressive supranuclear palsy (PSP). We report the interrelationship of NMS in MSA, PSP, and PD. Methods We studied 117 cases of PD and 57 of Atypical Parkinsonism. Out of the 57 patients, 31 had multiple systemic atrophy parkinsonian subtype (MSA-P), 14 had multiple systemic atrophy cerebellar dysfunction subtype (MSA-C), and 12 had PSP. We assessed the condition of the patients using the United Parkinson's Disease Rating Scale part III (UPDRS-III), the modified Hoehn & Yahr scale (H&Y), the non-motor symptom scale (NMSS), and the Parkinson's Disease Questionnaire (PDQ-39). Results In Atypical Parkinsonism, the NMSS scores significantly correlated with PDQ-39 scores, but not with UPDRS-III. In the MSA-P group, the mood/cognitive domain significantly correlated with both the urinary and sleep/fatigue domains. In the MSA-C group, the sleep/fatigue domain correlated with the mood/cognition and cardiovascular domains. Finally, in the PSP and PD groups, the attention/memory domain significantly correlated with the sleep/fatigue and mood/cognition domains. Discussion These results suggest that, with respect to cognitive function, dysautonomia and sleep/fatigue are detrimental factors in MSA and PSP, respectively.",
keywords = "Multiple system atrophy, Non-motor symptoms, Parkinson's disease, Progressive supranuclear palsy, Quality of life",
author = "Lee, {Chan Nyoung} and Minjik Kim and Lee, {Hye Mi} and Jang, {Ji Wan} and Lee, {Seon Min} and Do-Young Kwon and Park, {Kun Woo} and Koh, {Seong Beom}",
year = "2013",
month = "4",
day = "15",
doi = "10.1016/j.jns.2013.01.034",
language = "English",
volume = "327",
pages = "15--21",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - The interrelationship between non-motor symptoms in Atypical Parkinsonism

AU - Lee, Chan Nyoung

AU - Kim, Minjik

AU - Lee, Hye Mi

AU - Jang, Ji Wan

AU - Lee, Seon Min

AU - Kwon, Do-Young

AU - Park, Kun Woo

AU - Koh, Seong Beom

PY - 2013/4/15

Y1 - 2013/4/15

N2 - Background Atypical Parkinsonism is less common and has more severe symptoms than Parkinson's disease (PD). Little is known about the non-motor symptom (NMS) characteristics of multiple systemic atrophy (MSA) or progressive supranuclear palsy (PSP). We report the interrelationship of NMS in MSA, PSP, and PD. Methods We studied 117 cases of PD and 57 of Atypical Parkinsonism. Out of the 57 patients, 31 had multiple systemic atrophy parkinsonian subtype (MSA-P), 14 had multiple systemic atrophy cerebellar dysfunction subtype (MSA-C), and 12 had PSP. We assessed the condition of the patients using the United Parkinson's Disease Rating Scale part III (UPDRS-III), the modified Hoehn & Yahr scale (H&Y), the non-motor symptom scale (NMSS), and the Parkinson's Disease Questionnaire (PDQ-39). Results In Atypical Parkinsonism, the NMSS scores significantly correlated with PDQ-39 scores, but not with UPDRS-III. In the MSA-P group, the mood/cognitive domain significantly correlated with both the urinary and sleep/fatigue domains. In the MSA-C group, the sleep/fatigue domain correlated with the mood/cognition and cardiovascular domains. Finally, in the PSP and PD groups, the attention/memory domain significantly correlated with the sleep/fatigue and mood/cognition domains. Discussion These results suggest that, with respect to cognitive function, dysautonomia and sleep/fatigue are detrimental factors in MSA and PSP, respectively.

AB - Background Atypical Parkinsonism is less common and has more severe symptoms than Parkinson's disease (PD). Little is known about the non-motor symptom (NMS) characteristics of multiple systemic atrophy (MSA) or progressive supranuclear palsy (PSP). We report the interrelationship of NMS in MSA, PSP, and PD. Methods We studied 117 cases of PD and 57 of Atypical Parkinsonism. Out of the 57 patients, 31 had multiple systemic atrophy parkinsonian subtype (MSA-P), 14 had multiple systemic atrophy cerebellar dysfunction subtype (MSA-C), and 12 had PSP. We assessed the condition of the patients using the United Parkinson's Disease Rating Scale part III (UPDRS-III), the modified Hoehn & Yahr scale (H&Y), the non-motor symptom scale (NMSS), and the Parkinson's Disease Questionnaire (PDQ-39). Results In Atypical Parkinsonism, the NMSS scores significantly correlated with PDQ-39 scores, but not with UPDRS-III. In the MSA-P group, the mood/cognitive domain significantly correlated with both the urinary and sleep/fatigue domains. In the MSA-C group, the sleep/fatigue domain correlated with the mood/cognition and cardiovascular domains. Finally, in the PSP and PD groups, the attention/memory domain significantly correlated with the sleep/fatigue and mood/cognition domains. Discussion These results suggest that, with respect to cognitive function, dysautonomia and sleep/fatigue are detrimental factors in MSA and PSP, respectively.

KW - Multiple system atrophy

KW - Non-motor symptoms

KW - Parkinson's disease

KW - Progressive supranuclear palsy

KW - Quality of life

UR - http://www.scopus.com/inward/record.url?scp=84875216628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875216628&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2013.01.034

DO - 10.1016/j.jns.2013.01.034

M3 - Article

C2 - 23428208

AN - SCOPUS:84875216628

VL - 327

SP - 15

EP - 21

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -