The KMDS-NATION study: Korean movement disorders society multicenter assessment of non-motor symptoms and quality of life in Parkinson’s disease NATION study group

Do-Young Kwon, Seong Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han Joon Kim, Hae Won Shin, Jinyoung Youn, Kun Woo Park, Sun Ah Choi, Sang Jin Kim, Seong Min Choi, Ji Yun Park, Beom S. Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong Ho Park, Tae Beom Ahn, Won Chan Kim, Hyun Sook KimSang Myung Cheon, Hee Tae Kim, Jee Young Lee, Ji Sun Kim, Eun Joo Kim, Jong Min Kim, Kwang Soo Lee, Joong Seok Kim, Min Jeong Kim, Jong Sam Baik, Ki Jong Park, Hee Jin Kim, Mee Young Park, Ji Hoon Kang, Sook Kun Song, Yong Duk Kim, Ji Young Yun, Ho Won Lee, Hyung Geun Oh, Jinwhan Cho, In Uk Song, Young H. Sohn, Phil Hyu Lee, Jae Woo Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background and Purpose Nonmotor symptoms (NMS) in Parkinson’s disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients. Methods We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for assessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms. Results In total, 98.1% of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage. Conclusions The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather exert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strategies is warranted to improve the HrQoL in PD patients.

Original languageEnglish
Pages (from-to)393-402
Number of pages10
JournalJournal of Clinical Neurology (Korea)
Volume12
Issue number4
DOIs
Publication statusPublished - 2016 Oct 1

Keywords

  • Non-motor symptoms
  • Parkinson’s disease
  • Quality of life

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Kwon, D-Y., Koh, S. B., Lee, J. H., Park, H. K., Kim, H. J., Shin, H. W., Youn, J., Park, K. W., Choi, S. A., Kim, S. J., Choi, S. M., Park, J. Y., Jeon, B. S., Kim, J. Y., Chung, S. J., Lee, C. S., Park, J. H., Ahn, T. B., Kim, W. C., ... Kim, J. W. (2016). The KMDS-NATION study: Korean movement disorders society multicenter assessment of non-motor symptoms and quality of life in Parkinson’s disease NATION study group. Journal of Clinical Neurology (Korea), 12(4), 393-402. https://doi.org/10.3988/jcn.2016.12.4.393