The Long-Term Safety of Anticoagulation Strategy after Radiofrequency Catheter Ablation of Atrial Fibrillation

Jihan Park, Kyong Jeong Ko, Pu Kyong Han, Ra Seung Lim, Jin Keun Jang, Hwan Cheol Park, Young Hoon Kim

Research output: Contribution to journalArticle

Abstract

Background: The purpose of this study was to investigate the safety and efficacy of standard anticoagulation (SA) over 3 months after radiofrequency Catheter ablation (RFCA) of atrial fibrillation (AF) in comparison with the early-stopped warfarinization (EW) within 3 months. Methods and Results: We compared safety between SA (n=50) and EW (n = 59) group in 109 patients who underwent RFCA of AF (78 males, 55.9 ± 11 years old, paroxysmal AF 59.6%, CHADS2 score 1.5 ± 0.9, duration of follow up 693.1 ± 234.6 days, duration of AF 46.7 ± 42.5 months) There was no significant difference in CHADS2 score (1.5 ± 0.9 vs 1.4 ± 0.8, P = NS) between SA and EW group. Compared to EW group, uninterrupted preprocedural warfarinization (70.6% vs 39.4%, P = 0.014) was greater in SA group, therefore, INR value (1.47 ± 0.51 vs 1.14 ± 0.28, P = 0.002) at the procedure was higher. However, the incidence of hemorrhagic complications (11.9% vs 6.0%, P = NS) or the thromboembolic events (1.7% vs 0.0%, P = NS) was not different between two groups. Conclusion: In patients with low to intermediate risk of thromboembolism (mean CHADS2 1.5) early stopped warfarinization within 3 months after Catheter ablation of AF had comparable safety with warfarinization over 3 months. Further prospective study in large scale is warranted to determine long-term safety of each anticoagulation strategy.

Original languageEnglish
Number of pages1
JournalJournal of Arrhythmia
Volume27
Issue number4
DOIs
Publication statusPublished - 2011 Jan 1

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Catheter Ablation
Atrial Fibrillation
Safety
International Normalized Ratio
Thromboembolism
Prospective Studies
Incidence

Keywords

  • ablation
  • AF
  • warfarin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The Long-Term Safety of Anticoagulation Strategy after Radiofrequency Catheter Ablation of Atrial Fibrillation. / Park, Jihan; Ko, Kyong Jeong; Han, Pu Kyong; Lim, Ra Seung; Jang, Jin Keun; Park, Hwan Cheol; Kim, Young Hoon.

In: Journal of Arrhythmia, Vol. 27, No. 4, 01.01.2011.

Research output: Contribution to journalArticle

Park, Jihan ; Ko, Kyong Jeong ; Han, Pu Kyong ; Lim, Ra Seung ; Jang, Jin Keun ; Park, Hwan Cheol ; Kim, Young Hoon. / The Long-Term Safety of Anticoagulation Strategy after Radiofrequency Catheter Ablation of Atrial Fibrillation. In: Journal of Arrhythmia. 2011 ; Vol. 27, No. 4.
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abstract = "Background: The purpose of this study was to investigate the safety and efficacy of standard anticoagulation (SA) over 3 months after radiofrequency Catheter ablation (RFCA) of atrial fibrillation (AF) in comparison with the early-stopped warfarinization (EW) within 3 months. Methods and Results: We compared safety between SA (n=50) and EW (n = 59) group in 109 patients who underwent RFCA of AF (78 males, 55.9 ± 11 years old, paroxysmal AF 59.6{\%}, CHADS2 score 1.5 ± 0.9, duration of follow up 693.1 ± 234.6 days, duration of AF 46.7 ± 42.5 months) There was no significant difference in CHADS2 score (1.5 ± 0.9 vs 1.4 ± 0.8, P = NS) between SA and EW group. Compared to EW group, uninterrupted preprocedural warfarinization (70.6{\%} vs 39.4{\%}, P = 0.014) was greater in SA group, therefore, INR value (1.47 ± 0.51 vs 1.14 ± 0.28, P = 0.002) at the procedure was higher. However, the incidence of hemorrhagic complications (11.9{\%} vs 6.0{\%}, P = NS) or the thromboembolic events (1.7{\%} vs 0.0{\%}, P = NS) was not different between two groups. Conclusion: In patients with low to intermediate risk of thromboembolism (mean CHADS2 1.5) early stopped warfarinization within 3 months after Catheter ablation of AF had comparable safety with warfarinization over 3 months. Further prospective study in large scale is warranted to determine long-term safety of each anticoagulation strategy.",
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AB - Background: The purpose of this study was to investigate the safety and efficacy of standard anticoagulation (SA) over 3 months after radiofrequency Catheter ablation (RFCA) of atrial fibrillation (AF) in comparison with the early-stopped warfarinization (EW) within 3 months. Methods and Results: We compared safety between SA (n=50) and EW (n = 59) group in 109 patients who underwent RFCA of AF (78 males, 55.9 ± 11 years old, paroxysmal AF 59.6%, CHADS2 score 1.5 ± 0.9, duration of follow up 693.1 ± 234.6 days, duration of AF 46.7 ± 42.5 months) There was no significant difference in CHADS2 score (1.5 ± 0.9 vs 1.4 ± 0.8, P = NS) between SA and EW group. Compared to EW group, uninterrupted preprocedural warfarinization (70.6% vs 39.4%, P = 0.014) was greater in SA group, therefore, INR value (1.47 ± 0.51 vs 1.14 ± 0.28, P = 0.002) at the procedure was higher. However, the incidence of hemorrhagic complications (11.9% vs 6.0%, P = NS) or the thromboembolic events (1.7% vs 0.0%, P = NS) was not different between two groups. Conclusion: In patients with low to intermediate risk of thromboembolism (mean CHADS2 1.5) early stopped warfarinization within 3 months after Catheter ablation of AF had comparable safety with warfarinization over 3 months. Further prospective study in large scale is warranted to determine long-term safety of each anticoagulation strategy.

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