Abstract
Background: The purpose of this study was to investigate the safety and efficacy of standard anticoagulation (SA) over 3 months after radiofrequency Catheter ablation (RFCA) of atrial fibrillation (AF) in comparison with the early-stopped warfarinization (EW) within 3 months. Methods and Results: We compared safety between SA (n=50) and EW (n = 59) group in 109 patients who underwent RFCA of AF (78 males, 55.9 ± 11 years old, paroxysmal AF 59.6%, CHADS2 score 1.5 ± 0.9, duration of follow up 693.1 ± 234.6 days, duration of AF 46.7 ± 42.5 months) There was no significant difference in CHADS2 score (1.5 ± 0.9 vs 1.4 ± 0.8, P = NS) between SA and EW group. Compared to EW group, uninterrupted preprocedural warfarinization (70.6% vs 39.4%, P = 0.014) was greater in SA group, therefore, INR value (1.47 ± 0.51 vs 1.14 ± 0.28, P = 0.002) at the procedure was higher. However, the incidence of hemorrhagic complications (11.9% vs 6.0%, P = NS) or the thromboembolic events (1.7% vs 0.0%, P = NS) was not different between two groups. Conclusion: In patients with low to intermediate risk of thromboembolism (mean CHADS2 1.5) early stopped warfarinization within 3 months after Catheter ablation of AF had comparable safety with warfarinization over 3 months. Further prospective study in large scale is warranted to determine long-term safety of each anticoagulation strategy.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Journal | Journal of Arrhythmia |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2011 Jan 1 |
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Keywords
- ablation
- AF
- warfarin
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
The Long-Term Safety of Anticoagulation Strategy after Radiofrequency Catheter Ablation of Atrial Fibrillation. / Park, Jihan; Ko, Kyong Jeong; Han, Pu Kyong; Lim, Ra Seung; Jang, Jin Keun; Park, Hwan Cheol; Kim, Young Hoon.
In: Journal of Arrhythmia, Vol. 27, No. 4, 01.01.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Long-Term Safety of Anticoagulation Strategy after Radiofrequency Catheter Ablation of Atrial Fibrillation
AU - Park, Jihan
AU - Ko, Kyong Jeong
AU - Han, Pu Kyong
AU - Lim, Ra Seung
AU - Jang, Jin Keun
AU - Park, Hwan Cheol
AU - Kim, Young Hoon
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Background: The purpose of this study was to investigate the safety and efficacy of standard anticoagulation (SA) over 3 months after radiofrequency Catheter ablation (RFCA) of atrial fibrillation (AF) in comparison with the early-stopped warfarinization (EW) within 3 months. Methods and Results: We compared safety between SA (n=50) and EW (n = 59) group in 109 patients who underwent RFCA of AF (78 males, 55.9 ± 11 years old, paroxysmal AF 59.6%, CHADS2 score 1.5 ± 0.9, duration of follow up 693.1 ± 234.6 days, duration of AF 46.7 ± 42.5 months) There was no significant difference in CHADS2 score (1.5 ± 0.9 vs 1.4 ± 0.8, P = NS) between SA and EW group. Compared to EW group, uninterrupted preprocedural warfarinization (70.6% vs 39.4%, P = 0.014) was greater in SA group, therefore, INR value (1.47 ± 0.51 vs 1.14 ± 0.28, P = 0.002) at the procedure was higher. However, the incidence of hemorrhagic complications (11.9% vs 6.0%, P = NS) or the thromboembolic events (1.7% vs 0.0%, P = NS) was not different between two groups. Conclusion: In patients with low to intermediate risk of thromboembolism (mean CHADS2 1.5) early stopped warfarinization within 3 months after Catheter ablation of AF had comparable safety with warfarinization over 3 months. Further prospective study in large scale is warranted to determine long-term safety of each anticoagulation strategy.
AB - Background: The purpose of this study was to investigate the safety and efficacy of standard anticoagulation (SA) over 3 months after radiofrequency Catheter ablation (RFCA) of atrial fibrillation (AF) in comparison with the early-stopped warfarinization (EW) within 3 months. Methods and Results: We compared safety between SA (n=50) and EW (n = 59) group in 109 patients who underwent RFCA of AF (78 males, 55.9 ± 11 years old, paroxysmal AF 59.6%, CHADS2 score 1.5 ± 0.9, duration of follow up 693.1 ± 234.6 days, duration of AF 46.7 ± 42.5 months) There was no significant difference in CHADS2 score (1.5 ± 0.9 vs 1.4 ± 0.8, P = NS) between SA and EW group. Compared to EW group, uninterrupted preprocedural warfarinization (70.6% vs 39.4%, P = 0.014) was greater in SA group, therefore, INR value (1.47 ± 0.51 vs 1.14 ± 0.28, P = 0.002) at the procedure was higher. However, the incidence of hemorrhagic complications (11.9% vs 6.0%, P = NS) or the thromboembolic events (1.7% vs 0.0%, P = NS) was not different between two groups. Conclusion: In patients with low to intermediate risk of thromboembolism (mean CHADS2 1.5) early stopped warfarinization within 3 months after Catheter ablation of AF had comparable safety with warfarinization over 3 months. Further prospective study in large scale is warranted to determine long-term safety of each anticoagulation strategy.
KW - ablation
KW - AF
KW - warfarin
UR - http://www.scopus.com/inward/record.url?scp=85008727780&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85008727780&partnerID=8YFLogxK
U2 - 10.4020/jhrs.27.PE4_024
DO - 10.4020/jhrs.27.PE4_024
M3 - Article
AN - SCOPUS:85008727780
VL - 27
JO - Journal of Arrhythmia
JF - Journal of Arrhythmia
SN - 1880-4276
IS - 4
ER -