The Mach-Zehnder interferometer based on silicon oxides for label free detection of C-reactive protein (CRP)

Jongin Hong, Daesung Yoon, Tae Song Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The C-reactive protein (CRP) is a very important inflammation biomarker and a major predictor of cardiovascular disease (CVD) in human. We demonstrated here on a new approach to determine the binding of label free CRP to monoclonal anti-CRP using the Mach-Zehnder interferometer based on silicon oxides with the detection limit of 1 ng/mL or even less at the operating wavelength of 1,550 nm. The building block, single-mode waveguide of total internal reflection, was precisely designed using a finite element method (FEM) and so we suggested the guideline of microfabrication to achieve it. We also firstly introduced the calixcrown self-assembled monolayers (SAMs), which guaranteed the activity of capture proteins and the correct orientation, to immobilize the monoclonal anti-CRP on PECVD silicon oxides into the biosensors based on the interaction of the evanescent field of the guided light with the surrounding environment.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalBiochip Journal
Volume3
Issue number1
Publication statusPublished - 2009 Mar
Externally publishedYes

Keywords

  • Biosensor
  • C-reactive protein
  • Finite element method
  • Mach-zehnder interferometer
  • Silicon oxide

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

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