The mechanical response of hIAPP nanowires based on different bending direction simulations

J. I. Kim, M. Lee, I. Baek, G. Yoon, Sung Soo Na

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Amyloid proteins, implicated in numerous aging-related diseases, possess remarkable mechanical properties. Polymorphism leads to different arrangements of β sheets in amyloid fibrils, which changes the characteristics of the hydrogen bond network that determines their mechanical properties and structural characteristics. We performed bending simulations using molecular dynamics methods under constant-velocity conditions in different bending directions. Two different fibril structures, parallel/homo and parallel/hetero, of hIAPP amyloids were considered. Though the bending configuration influences the toughness of the material, our results indicate that the basic material behavior is affected by the β-sheet arrangement that is determined by the type of polymorphism in amyloid fibrils.

Original languageEnglish
Pages (from-to)18493-18500
Number of pages8
JournalPhysical Chemistry Chemical Physics
Volume16
Issue number34
DOIs
Publication statusPublished - 2014 Sep 14

Fingerprint

Nanowires
Amyloid
nanowires
polymorphism
Polymorphism
mechanical properties
Amyloidogenic Proteins
Mechanical properties
simulation
Molecular Dynamics Simulation
toughness
Toughness
Molecular dynamics
Hydrogen
Hydrogen bonds
Aging of materials
hydrogen bonds
molecular dynamics
proteins
configurations

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Physics and Astronomy(all)

Cite this

The mechanical response of hIAPP nanowires based on different bending direction simulations. / Kim, J. I.; Lee, M.; Baek, I.; Yoon, G.; Na, Sung Soo.

In: Physical Chemistry Chemical Physics, Vol. 16, No. 34, 14.09.2014, p. 18493-18500.

Research output: Contribution to journalArticle

Kim, J. I. ; Lee, M. ; Baek, I. ; Yoon, G. ; Na, Sung Soo. / The mechanical response of hIAPP nanowires based on different bending direction simulations. In: Physical Chemistry Chemical Physics. 2014 ; Vol. 16, No. 34. pp. 18493-18500.
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