The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis

Jun Seo Oh, R. Takahashi, S. Kondo, A. Mizoguchi, E. Adachi, R. M. Sasahara, S. Nishimura, Y. Imamura, H. Kitayama, D. B. Alexander, C. Ide, T. P. Horan, T. Arakawa, H. Yoshida, S. I. Nishikawa, Y. Itoh, M. Seiki, S. Itohara, C. Takahashi, M. M. Noda

Research output: Contribution to journalArticle

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Abstract

Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling. We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates MMP-9 and inhibits tumor invasion and metastasis. Here we show that RECK regulates two other MMPs, MMP-2 and MT1-MMP, known to be involved in cancer progression, that mice lacking a functional RECK gene die around E10.5 with defects in collagen fibrils, the basal lamina, and vascular development, and that this phenotype is partially suppressed by MMP-2 null mutation. Also, vascular sprouting is dramatically suppressed in tumors derived from RECK-expressing fibrosarcoma cells grown in nude mice. These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis.

Original languageEnglish
Pages (from-to)789-800
Number of pages12
JournalCell
Volume107
Issue number6
DOIs
Publication statusPublished - 2001 Dec 14
Externally publishedYes

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Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinase 2
Extracellular Matrix
Tumors
Membranes
Matrix Metalloproteinases
Matrix Metalloproteinase 14
Blood Vessels
Neoplasms
Matrix Metalloproteinase 9
Fibrosarcoma
Membrane Glycoproteins
Glycoproteins
Collagen
Genes
Cells
Basement Membrane
Nude Mice
Defects
Down-Regulation

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Oh, J. S., Takahashi, R., Kondo, S., Mizoguchi, A., Adachi, E., Sasahara, R. M., ... Noda, M. M. (2001). The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell, 107(6), 789-800. https://doi.org/10.1016/S0092-8674(01)00597-9

The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. / Oh, Jun Seo; Takahashi, R.; Kondo, S.; Mizoguchi, A.; Adachi, E.; Sasahara, R. M.; Nishimura, S.; Imamura, Y.; Kitayama, H.; Alexander, D. B.; Ide, C.; Horan, T. P.; Arakawa, T.; Yoshida, H.; Nishikawa, S. I.; Itoh, Y.; Seiki, M.; Itohara, S.; Takahashi, C.; Noda, M. M.

In: Cell, Vol. 107, No. 6, 14.12.2001, p. 789-800.

Research output: Contribution to journalArticle

Oh, JS, Takahashi, R, Kondo, S, Mizoguchi, A, Adachi, E, Sasahara, RM, Nishimura, S, Imamura, Y, Kitayama, H, Alexander, DB, Ide, C, Horan, TP, Arakawa, T, Yoshida, H, Nishikawa, SI, Itoh, Y, Seiki, M, Itohara, S, Takahashi, C & Noda, MM 2001, 'The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis', Cell, vol. 107, no. 6, pp. 789-800. https://doi.org/10.1016/S0092-8674(01)00597-9
Oh, Jun Seo ; Takahashi, R. ; Kondo, S. ; Mizoguchi, A. ; Adachi, E. ; Sasahara, R. M. ; Nishimura, S. ; Imamura, Y. ; Kitayama, H. ; Alexander, D. B. ; Ide, C. ; Horan, T. P. ; Arakawa, T. ; Yoshida, H. ; Nishikawa, S. I. ; Itoh, Y. ; Seiki, M. ; Itohara, S. ; Takahashi, C. ; Noda, M. M. / The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. In: Cell. 2001 ; Vol. 107, No. 6. pp. 789-800.
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AU - Kondo, S.

AU - Mizoguchi, A.

AU - Adachi, E.

AU - Sasahara, R. M.

AU - Nishimura, S.

AU - Imamura, Y.

AU - Kitayama, H.

AU - Alexander, D. B.

AU - Ide, C.

AU - Horan, T. P.

AU - Arakawa, T.

AU - Yoshida, H.

AU - Nishikawa, S. I.

AU - Itoh, Y.

AU - Seiki, M.

AU - Itohara, S.

AU - Takahashi, C.

AU - Noda, M. M.

PY - 2001/12/14

Y1 - 2001/12/14

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