The microbiota-gut-brain axis in neuropsychiatric disorders: Pathophysiological mechanisms and novel treatments

Yong Ku Kim, Cheolmin Shin

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Background: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. Method: This review provides that the summarization of the communication among microbiota, gut and brain and the results of preclinical and clinical studies on gut microbiota used in treatments for neuropsychiatric disorders. Result: Recent studies have reported that diverse forms of neuropsychiatric disorders (such as autism, depression, anxiety, and schizophrenia) are associated with or modulated by variations in the microbiome, by microbial substrates, and by exogenous prebiotics, antibiotics, and probiotics. Conclusion: The microbiota–gut–brain axis might provide novel targets for prevention and treatment of neuropsychiatric disorders. However, further studies are required to substantiate the clinical use of probiotics, prebiotics and FMT.

Original languageEnglish
Pages (from-to)559-573
Number of pages15
JournalCurrent Neuropharmacology
Volume16
Issue number5
DOIs
Publication statusPublished - 2018 Jan 1

Keywords

  • Enteric microbiota
  • Gut microbiota
  • Gut-brain axis
  • Microbiota-gut-brain axis
  • Prebiotics
  • Probiotics

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'The microbiota-gut-brain axis in neuropsychiatric disorders: Pathophysiological mechanisms and novel treatments'. Together they form a unique fingerprint.

  • Cite this