The microbiota-gut-brain axis in neuropsychiatric disorders: Pathophysiological mechanisms and novel treatments

Yong Ku Kim, Cheolmin Shin

    Research output: Contribution to journalReview articlepeer-review

    59 Citations (Scopus)

    Abstract

    Background: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. Method: This review provides that the summarization of the communication among microbiota, gut and brain and the results of preclinical and clinical studies on gut microbiota used in treatments for neuropsychiatric disorders. Result: Recent studies have reported that diverse forms of neuropsychiatric disorders (such as autism, depression, anxiety, and schizophrenia) are associated with or modulated by variations in the microbiome, by microbial substrates, and by exogenous prebiotics, antibiotics, and probiotics. Conclusion: The microbiota–gut–brain axis might provide novel targets for prevention and treatment of neuropsychiatric disorders. However, further studies are required to substantiate the clinical use of probiotics, prebiotics and FMT.

    Original languageEnglish
    Pages (from-to)559-573
    Number of pages15
    JournalCurrent Neuropharmacology
    Volume16
    Issue number5
    DOIs
    Publication statusPublished - 2018

    Keywords

    • Enteric microbiota
    • Gut microbiota
    • Gut-brain axis
    • Microbiota-gut-brain axis
    • Prebiotics
    • Probiotics

    ASJC Scopus subject areas

    • Pharmacology
    • Neurology
    • Clinical Neurology
    • Psychiatry and Mental health
    • Pharmacology (medical)

    Fingerprint

    Dive into the research topics of 'The microbiota-gut-brain axis in neuropsychiatric disorders: Pathophysiological mechanisms and novel treatments'. Together they form a unique fingerprint.

    Cite this