The microbiota-gut-brain axis in neuropsychiatric disorders: Pathophysiological mechanisms and novel treatments

Yong Ku Kim, Cheolmin Shin

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Background: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. Method: This review provides that the summarization of the communication among microbiota, gut and brain and the results of preclinical and clinical studies on gut microbiota used in treatments for neuropsychiatric disorders. Result: Recent studies have reported that diverse forms of neuropsychiatric disorders (such as autism, depression, anxiety, and schizophrenia) are associated with or modulated by variations in the microbiome, by microbial substrates, and by exogenous prebiotics, antibiotics, and probiotics. Conclusion: The microbiota–gut–brain axis might provide novel targets for prevention and treatment of neuropsychiatric disorders. However, further studies are required to substantiate the clinical use of probiotics, prebiotics and FMT.

Original languageEnglish
Pages (from-to)559-573
Number of pages15
JournalCurrent Neuropharmacology
Volume16
Issue number5
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Microbiota
Prebiotics
Probiotics
Brain
Communication
Neurosciences
Autistic Disorder
Schizophrenia
Anxiety
Depression
Anti-Bacterial Agents
Research
Gastrointestinal Microbiome

Keywords

  • Enteric microbiota
  • Gut microbiota
  • Gut-brain axis
  • Microbiota-gut-brain axis
  • Prebiotics
  • Probiotics

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

The microbiota-gut-brain axis in neuropsychiatric disorders : Pathophysiological mechanisms and novel treatments. / Kim, Yong Ku; Shin, Cheolmin.

In: Current Neuropharmacology, Vol. 16, No. 5, 01.01.2018, p. 559-573.

Research output: Contribution to journalReview article

@article{b29a250e39574e75ba297b2207cc2f49,
title = "The microbiota-gut-brain axis in neuropsychiatric disorders: Pathophysiological mechanisms and novel treatments",
abstract = "Background: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. Method: This review provides that the summarization of the communication among microbiota, gut and brain and the results of preclinical and clinical studies on gut microbiota used in treatments for neuropsychiatric disorders. Result: Recent studies have reported that diverse forms of neuropsychiatric disorders (such as autism, depression, anxiety, and schizophrenia) are associated with or modulated by variations in the microbiome, by microbial substrates, and by exogenous prebiotics, antibiotics, and probiotics. Conclusion: The microbiota–gut–brain axis might provide novel targets for prevention and treatment of neuropsychiatric disorders. However, further studies are required to substantiate the clinical use of probiotics, prebiotics and FMT.",
keywords = "Enteric microbiota, Gut microbiota, Gut-brain axis, Microbiota-gut-brain axis, Prebiotics, Probiotics",
author = "Kim, {Yong Ku} and Cheolmin Shin",
year = "2018",
month = "1",
day = "1",
doi = "10.2174/1570159X15666170915141036",
language = "English",
volume = "16",
pages = "559--573",
journal = "Current Neuropharmacology",
issn = "1570-159X",
publisher = "Bentham Science Publishers B.V.",
number = "5",

}

TY - JOUR

T1 - The microbiota-gut-brain axis in neuropsychiatric disorders

T2 - Pathophysiological mechanisms and novel treatments

AU - Kim, Yong Ku

AU - Shin, Cheolmin

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. Method: This review provides that the summarization of the communication among microbiota, gut and brain and the results of preclinical and clinical studies on gut microbiota used in treatments for neuropsychiatric disorders. Result: Recent studies have reported that diverse forms of neuropsychiatric disorders (such as autism, depression, anxiety, and schizophrenia) are associated with or modulated by variations in the microbiome, by microbial substrates, and by exogenous prebiotics, antibiotics, and probiotics. Conclusion: The microbiota–gut–brain axis might provide novel targets for prevention and treatment of neuropsychiatric disorders. However, further studies are required to substantiate the clinical use of probiotics, prebiotics and FMT.

AB - Background: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. Method: This review provides that the summarization of the communication among microbiota, gut and brain and the results of preclinical and clinical studies on gut microbiota used in treatments for neuropsychiatric disorders. Result: Recent studies have reported that diverse forms of neuropsychiatric disorders (such as autism, depression, anxiety, and schizophrenia) are associated with or modulated by variations in the microbiome, by microbial substrates, and by exogenous prebiotics, antibiotics, and probiotics. Conclusion: The microbiota–gut–brain axis might provide novel targets for prevention and treatment of neuropsychiatric disorders. However, further studies are required to substantiate the clinical use of probiotics, prebiotics and FMT.

KW - Enteric microbiota

KW - Gut microbiota

KW - Gut-brain axis

KW - Microbiota-gut-brain axis

KW - Prebiotics

KW - Probiotics

UR - http://www.scopus.com/inward/record.url?scp=85047663687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047663687&partnerID=8YFLogxK

U2 - 10.2174/1570159X15666170915141036

DO - 10.2174/1570159X15666170915141036

M3 - Review article

C2 - 28925886

AN - SCOPUS:85047663687

VL - 16

SP - 559

EP - 573

JO - Current Neuropharmacology

JF - Current Neuropharmacology

SN - 1570-159X

IS - 5

ER -