Abstract
Background: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. Method: This review provides that the summarization of the communication among microbiota, gut and brain and the results of preclinical and clinical studies on gut microbiota used in treatments for neuropsychiatric disorders. Result: Recent studies have reported that diverse forms of neuropsychiatric disorders (such as autism, depression, anxiety, and schizophrenia) are associated with or modulated by variations in the microbiome, by microbial substrates, and by exogenous prebiotics, antibiotics, and probiotics. Conclusion: The microbiota–gut–brain axis might provide novel targets for prevention and treatment of neuropsychiatric disorders. However, further studies are required to substantiate the clinical use of probiotics, prebiotics and FMT.
| Original language | English |
|---|---|
| Pages (from-to) | 559-573 |
| Number of pages | 15 |
| Journal | Current Neuropharmacology |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
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Keywords
- Enteric microbiota
- Gut microbiota
- Gut-brain axis
- Microbiota-gut-brain axis
- Prebiotics
- Probiotics
ASJC Scopus subject areas
- Pharmacology
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Pharmacology (medical)
Cite this
The microbiota-gut-brain axis in neuropsychiatric disorders : Pathophysiological mechanisms and novel treatments. / Kim, Yong Ku; Shin, Cheolmin.
In: Current Neuropharmacology, Vol. 16, No. 5, 01.01.2018, p. 559-573.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The microbiota-gut-brain axis in neuropsychiatric disorders
T2 - Pathophysiological mechanisms and novel treatments
AU - Kim, Yong Ku
AU - Shin, Cheolmin
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. Method: This review provides that the summarization of the communication among microbiota, gut and brain and the results of preclinical and clinical studies on gut microbiota used in treatments for neuropsychiatric disorders. Result: Recent studies have reported that diverse forms of neuropsychiatric disorders (such as autism, depression, anxiety, and schizophrenia) are associated with or modulated by variations in the microbiome, by microbial substrates, and by exogenous prebiotics, antibiotics, and probiotics. Conclusion: The microbiota–gut–brain axis might provide novel targets for prevention and treatment of neuropsychiatric disorders. However, further studies are required to substantiate the clinical use of probiotics, prebiotics and FMT.
AB - Background: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. Method: This review provides that the summarization of the communication among microbiota, gut and brain and the results of preclinical and clinical studies on gut microbiota used in treatments for neuropsychiatric disorders. Result: Recent studies have reported that diverse forms of neuropsychiatric disorders (such as autism, depression, anxiety, and schizophrenia) are associated with or modulated by variations in the microbiome, by microbial substrates, and by exogenous prebiotics, antibiotics, and probiotics. Conclusion: The microbiota–gut–brain axis might provide novel targets for prevention and treatment of neuropsychiatric disorders. However, further studies are required to substantiate the clinical use of probiotics, prebiotics and FMT.
KW - Enteric microbiota
KW - Gut microbiota
KW - Gut-brain axis
KW - Microbiota-gut-brain axis
KW - Prebiotics
KW - Probiotics
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UR - http://www.scopus.com/inward/citedby.url?scp=85047663687&partnerID=8YFLogxK
U2 - 10.2174/1570159X15666170915141036
DO - 10.2174/1570159X15666170915141036
M3 - Review article
C2 - 28925886
AN - SCOPUS:85047663687
VL - 16
SP - 559
EP - 573
JO - Current Neuropharmacology
JF - Current Neuropharmacology
SN - 1570-159X
IS - 5
ER -