The microRNA-23a has limited roles in bone formation and homeostasis in vivo

Jonghoon Park, S. Wada, T. Ushida, T. Akimoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Recent studies have demonstrated that some microRNAs (miRNAs) inhibit bone formation by inhibiting the translation of specific genes. Several in vitro studies have suggested that miR-23a inhibits osteogenic differentiation by suppressing the translation of Runx2, a transcription factor essential for osteoblastogenesis, and of Satb2, a member of the special AT-rich binding protein family. In the present study, we used a gain-of-function approach to determine the roles of miR-23a in bone formation and homeostasis in vivo. The miR-23a transgenic (Tg) mice grew normally and their body size and weight were similar to those of wild-type (WT) littermates. Bone structure and morphology were similar in Tg and WT mice. Furthermore, the numbers of osteoblasts and osteoclasts, as well as their activities in bone were similar between Tg and WT mice. Our results indicate that miR-23 has limited roles in bone formation and maintenance in vivo in mice.

Original languageEnglish
Pages (from-to)711-719
Number of pages9
JournalPhysiological Research
Volume64
Issue number5
Publication statusPublished - 2015 Jan 1
Externally publishedYes

Fingerprint

MicroRNAs
Osteogenesis
Transgenic Mice
Homeostasis
Bone and Bones
Body Size
Osteoclasts
Osteoblasts
Carrier Proteins
Transcription Factors
Body Weight
Maintenance
Genes

Keywords

  • Micro-CT
  • Non-coding RNA
  • Runx2
  • Satb2

ASJC Scopus subject areas

  • Physiology

Cite this

The microRNA-23a has limited roles in bone formation and homeostasis in vivo. / Park, Jonghoon; Wada, S.; Ushida, T.; Akimoto, T.

In: Physiological Research, Vol. 64, No. 5, 01.01.2015, p. 711-719.

Research output: Contribution to journalArticle

Park, J, Wada, S, Ushida, T & Akimoto, T 2015, 'The microRNA-23a has limited roles in bone formation and homeostasis in vivo', Physiological Research, vol. 64, no. 5, pp. 711-719.
Park, Jonghoon ; Wada, S. ; Ushida, T. ; Akimoto, T. / The microRNA-23a has limited roles in bone formation and homeostasis in vivo. In: Physiological Research. 2015 ; Vol. 64, No. 5. pp. 711-719.
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