The mildly elevated serum bilirubin level is negatively associated with the incidence of end stage Renal disease in patients with IgA nephropathy

Ho Jun Chin, Hyun Jin Cho, Tae Woo Lee, Ki Young Na, Kook Hwan Oh, Kwon Wook Joo, Hyung Jin Yoon, Yon Su Kim, Curie Ahn, Jin Suk Han, Suhnggwon Kim, En Sil Jeon, Dong Chan Jin, Yong Lim Kim, Sun Hee Park, Chan Duck Kim, Young Rim Song, Seong Gyun Kim, Yoon Goo Kim, Jung Eun Lee & 64 others Yoon Kyu Oh, Chun Soo Lim, Sang Koo Lee, Dong Wan Chae, Won Yong Cho, Hyoung Kyu Kim, Sang Kyung Jo, Eun Hee Jang, Won Kim, Nam Ho Kim, Woo Kyun Bae, Hye Young Kim, Ki Sung Ahn, Jong Tae Cho, Eun Kyeong Lee, Ki Hyun Kim, Won Suk An, Seong Eun Kim, Choi Gyu Bog, Seung Jung Kim, Woo Kyung Chung, Hyun Hee Lee, Jaeseok Yang, Sejoong Kim, Se Ho Chang, Jung Woo Noh, Young Ki Lee, Seong Gyun Kim, Jieun Oh, Young Rim Song, Moon Jae Kim, Seoung Woo Lee, Yeong Hoon Kim, Won Do Park, Hyun Chul Kim, Sung Bae Park, Kyo Soon Kim, Won Yong Cho, Hyoung Kyu Kim, Sang Kyung Jo, Dae-Ryong Cha, Young Sun Kang, Young-Joo Kwon, Yong Lim Kim, Sun Hee Park, Chan Duck Kim, Dong Ho Yang, Ihm Soo Kwak, Soo Bong Lee, Dong Won Lee, Sang Heon Song, Eun Young Seoung, Su Jin Yoon, Chun Soo Lim, Yoon Kyu Oh, Kook Hwan Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn, Jin Suk Han, Kyu Beck Lee, Yoon Goo Kim, Jung Eun Lee, Sang Koo Lee

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Oxidative stress plays various roles in the development and progression of IgA nephropathy, while bilirubin is known as a potent antioxidant. We therefore hypothesized that serum bilirubin would be associated with renal prognosis in IgA nephropathy. The study subjects comprised 1,458 adult patients with primary IgA nephropathy in Korea. We grouped patients according to the following quartile levels of bilirubin: <0.4 mg/dL (Q1), 0.4-0.5 mg/dL (Q2), 0.6-0.7 mg/dL (Q3), and >0.8 mg/dL (Q4). The outcome data were obtained from the Korean Registry of end-stage renal disease (ESRD). Eighty patients (5.5%) contracted ESRD during a mean follow-up period of 44.9 months. The ESRD incidences were 10.7% in Q1, 8.2% in Q2, 2.8% in Q3, and 2.8% in Q4 (p<0.001). The relative risk of ESRD compared to that in Q1 was 0.307 (95% confidence interval [CI], 0.126-0.751) in Q3 and 0.315 (95% CI, 0.130-0.765) in Q4. The differences of ESRD incidence were greater in subgroups of males and of patients aged 35 yr or more, with serum albumin 4.0 g/dL or more, with normotension, with eGFR 60 mL/min/1.73 m2 or more, and with proteinuria less then 3+ by dipstick test. In conclusion, higher bilirubin level was negatively associated with ESRD incidence in IgA nephropathy.

Original languageEnglish
JournalJournal of Korean Medical Science
Volume24
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2009 Jan 1

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Bilirubin
Immunoglobulin A
Chronic Kidney Failure
Incidence
Serum
Confidence Intervals
Korea
Proteinuria
Serum Albumin
Registries
Oxidative Stress
Antioxidants
Kidney

Keywords

  • Bilirubin
  • Chronic
  • Glomerulonephritis
  • IGA
  • Kidney failure

ASJC Scopus subject areas

  • Medicine(all)

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The mildly elevated serum bilirubin level is negatively associated with the incidence of end stage Renal disease in patients with IgA nephropathy. / Chin, Ho Jun; Cho, Hyun Jin; Lee, Tae Woo; Na, Ki Young; Oh, Kook Hwan; Joo, Kwon Wook; Yoon, Hyung Jin; Kim, Yon Su; Ahn, Curie; Han, Jin Suk; Kim, Suhnggwon; Jeon, En Sil; Jin, Dong Chan; Kim, Yong Lim; Park, Sun Hee; Kim, Chan Duck; Song, Young Rim; Kim, Seong Gyun; Kim, Yoon Goo; Lee, Jung Eun; Oh, Yoon Kyu; Lim, Chun Soo; Lee, Sang Koo; Chae, Dong Wan; Cho, Won Yong; Kim, Hyoung Kyu; Jo, Sang Kyung; Jang, Eun Hee; Kim, Won; Kim, Nam Ho; Bae, Woo Kyun; Kim, Hye Young; Ahn, Ki Sung; Cho, Jong Tae; Lee, Eun Kyeong; Kim, Ki Hyun; An, Won Suk; Kim, Seong Eun; Bog, Choi Gyu; Kim, Seung Jung; Chung, Woo Kyung; Lee, Hyun Hee; Yang, Jaeseok; Kim, Sejoong; Chang, Se Ho; Noh, Jung Woo; Lee, Young Ki; Kim, Seong Gyun; Oh, Jieun; Song, Young Rim; Kim, Moon Jae; Lee, Seoung Woo; Kim, Yeong Hoon; Park, Won Do; Kim, Hyun Chul; Park, Sung Bae; Kim, Kyo Soon; Cho, Won Yong; Kim, Hyoung Kyu; Jo, Sang Kyung; Cha, Dae-Ryong; Kang, Young Sun; Kwon, Young-Joo; Kim, Yong Lim; Park, Sun Hee; Kim, Chan Duck; Yang, Dong Ho; Kwak, Ihm Soo; Lee, Soo Bong; Lee, Dong Won; Song, Sang Heon; Seoung, Eun Young; Yoon, Su Jin; Lim, Chun Soo; Oh, Yoon Kyu; Oh, Kook Hwan; Joo, Kwon Wook; Kim, Yon Su; Ahn, Curie; Han, Jin Suk; Lee, Kyu Beck; Kim, Yoon Goo; Lee, Jung Eun; Lee, Sang Koo.

In: Journal of Korean Medical Science, Vol. 24, No. SUPPL.1, 01.01.2009.

Research output: Contribution to journalArticle

Chin, HJ, Cho, HJ, Lee, TW, Na, KY, Oh, KH, Joo, KW, Yoon, HJ, Kim, YS, Ahn, C, Han, JS, Kim, S, Jeon, ES, Jin, DC, Kim, YL, Park, SH, Kim, CD, Song, YR, Kim, SG, Kim, YG, Lee, JE, Oh, YK, Lim, CS, Lee, SK, Chae, DW, Cho, WY, Kim, HK, Jo, SK, Jang, EH, Kim, W, Kim, NH, Bae, WK, Kim, HY, Ahn, KS, Cho, JT, Lee, EK, Kim, KH, An, WS, Kim, SE, Bog, CG, Kim, SJ, Chung, WK, Lee, HH, Yang, J, Kim, S, Chang, SH, Noh, JW, Lee, YK, Kim, SG, Oh, J, Song, YR, Kim, MJ, Lee, SW, Kim, YH, Park, WD, Kim, HC, Park, SB, Kim, KS, Cho, WY, Kim, HK, Jo, SK, Cha, D-R, Kang, YS, Kwon, Y-J, Kim, YL, Park, SH, Kim, CD, Yang, DH, Kwak, IS, Lee, SB, Lee, DW, Song, SH, Seoung, EY, Yoon, SJ, Lim, CS, Oh, YK, Oh, KH, Joo, KW, Kim, YS, Ahn, C, Han, JS, Lee, KB, Kim, YG, Lee, JE & Lee, SK 2009, 'The mildly elevated serum bilirubin level is negatively associated with the incidence of end stage Renal disease in patients with IgA nephropathy', Journal of Korean Medical Science, vol. 24, no. SUPPL.1. https://doi.org/10.3346/jkms.2009.24.S1.S22
Chin, Ho Jun ; Cho, Hyun Jin ; Lee, Tae Woo ; Na, Ki Young ; Oh, Kook Hwan ; Joo, Kwon Wook ; Yoon, Hyung Jin ; Kim, Yon Su ; Ahn, Curie ; Han, Jin Suk ; Kim, Suhnggwon ; Jeon, En Sil ; Jin, Dong Chan ; Kim, Yong Lim ; Park, Sun Hee ; Kim, Chan Duck ; Song, Young Rim ; Kim, Seong Gyun ; Kim, Yoon Goo ; Lee, Jung Eun ; Oh, Yoon Kyu ; Lim, Chun Soo ; Lee, Sang Koo ; Chae, Dong Wan ; Cho, Won Yong ; Kim, Hyoung Kyu ; Jo, Sang Kyung ; Jang, Eun Hee ; Kim, Won ; Kim, Nam Ho ; Bae, Woo Kyun ; Kim, Hye Young ; Ahn, Ki Sung ; Cho, Jong Tae ; Lee, Eun Kyeong ; Kim, Ki Hyun ; An, Won Suk ; Kim, Seong Eun ; Bog, Choi Gyu ; Kim, Seung Jung ; Chung, Woo Kyung ; Lee, Hyun Hee ; Yang, Jaeseok ; Kim, Sejoong ; Chang, Se Ho ; Noh, Jung Woo ; Lee, Young Ki ; Kim, Seong Gyun ; Oh, Jieun ; Song, Young Rim ; Kim, Moon Jae ; Lee, Seoung Woo ; Kim, Yeong Hoon ; Park, Won Do ; Kim, Hyun Chul ; Park, Sung Bae ; Kim, Kyo Soon ; Cho, Won Yong ; Kim, Hyoung Kyu ; Jo, Sang Kyung ; Cha, Dae-Ryong ; Kang, Young Sun ; Kwon, Young-Joo ; Kim, Yong Lim ; Park, Sun Hee ; Kim, Chan Duck ; Yang, Dong Ho ; Kwak, Ihm Soo ; Lee, Soo Bong ; Lee, Dong Won ; Song, Sang Heon ; Seoung, Eun Young ; Yoon, Su Jin ; Lim, Chun Soo ; Oh, Yoon Kyu ; Oh, Kook Hwan ; Joo, Kwon Wook ; Kim, Yon Su ; Ahn, Curie ; Han, Jin Suk ; Lee, Kyu Beck ; Kim, Yoon Goo ; Lee, Jung Eun ; Lee, Sang Koo. / The mildly elevated serum bilirubin level is negatively associated with the incidence of end stage Renal disease in patients with IgA nephropathy. In: Journal of Korean Medical Science. 2009 ; Vol. 24, No. SUPPL.1.
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abstract = "Oxidative stress plays various roles in the development and progression of IgA nephropathy, while bilirubin is known as a potent antioxidant. We therefore hypothesized that serum bilirubin would be associated with renal prognosis in IgA nephropathy. The study subjects comprised 1,458 adult patients with primary IgA nephropathy in Korea. We grouped patients according to the following quartile levels of bilirubin: <0.4 mg/dL (Q1), 0.4-0.5 mg/dL (Q2), 0.6-0.7 mg/dL (Q3), and >0.8 mg/dL (Q4). The outcome data were obtained from the Korean Registry of end-stage renal disease (ESRD). Eighty patients (5.5{\%}) contracted ESRD during a mean follow-up period of 44.9 months. The ESRD incidences were 10.7{\%} in Q1, 8.2{\%} in Q2, 2.8{\%} in Q3, and 2.8{\%} in Q4 (p<0.001). The relative risk of ESRD compared to that in Q1 was 0.307 (95{\%} confidence interval [CI], 0.126-0.751) in Q3 and 0.315 (95{\%} CI, 0.130-0.765) in Q4. The differences of ESRD incidence were greater in subgroups of males and of patients aged 35 yr or more, with serum albumin 4.0 g/dL or more, with normotension, with eGFR 60 mL/min/1.73 m2 or more, and with proteinuria less then 3+ by dipstick test. In conclusion, higher bilirubin level was negatively associated with ESRD incidence in IgA nephropathy.",
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author = "Chin, {Ho Jun} and Cho, {Hyun Jin} and Lee, {Tae Woo} and Na, {Ki Young} and Oh, {Kook Hwan} and Joo, {Kwon Wook} and Yoon, {Hyung Jin} and Kim, {Yon Su} and Curie Ahn and Han, {Jin Suk} and Suhnggwon Kim and Jeon, {En Sil} and Jin, {Dong Chan} and Kim, {Yong Lim} and Park, {Sun Hee} and Kim, {Chan Duck} and Song, {Young Rim} and Kim, {Seong Gyun} and Kim, {Yoon Goo} and Lee, {Jung Eun} and Oh, {Yoon Kyu} and Lim, {Chun Soo} and Lee, {Sang Koo} and Chae, {Dong Wan} and Cho, {Won Yong} and Kim, {Hyoung Kyu} and Jo, {Sang Kyung} and Jang, {Eun Hee} and Won Kim and Kim, {Nam Ho} and Bae, {Woo Kyun} and Kim, {Hye Young} and Ahn, {Ki Sung} and Cho, {Jong Tae} and Lee, {Eun Kyeong} and Kim, {Ki Hyun} and An, {Won Suk} and Kim, {Seong Eun} and Bog, {Choi Gyu} and Kim, {Seung Jung} and Chung, {Woo Kyung} and Lee, {Hyun Hee} and Jaeseok Yang and Sejoong Kim and Chang, {Se Ho} and Noh, {Jung Woo} and Lee, {Young Ki} and Kim, {Seong Gyun} and Jieun Oh and Song, {Young Rim} and Kim, {Moon Jae} and Lee, {Seoung Woo} and Kim, {Yeong Hoon} and Park, {Won Do} and Kim, {Hyun Chul} and Park, {Sung Bae} and Kim, {Kyo Soon} and Cho, {Won Yong} and Kim, {Hyoung Kyu} and Jo, {Sang Kyung} and Dae-Ryong Cha and Kang, {Young Sun} and Young-Joo Kwon and Kim, {Yong Lim} and Park, {Sun Hee} and Kim, {Chan Duck} and Yang, {Dong Ho} and Kwak, {Ihm Soo} and Lee, {Soo Bong} and Lee, {Dong Won} and Song, {Sang Heon} and Seoung, {Eun Young} and Yoon, {Su Jin} and Lim, {Chun Soo} and Oh, {Yoon Kyu} and Oh, {Kook Hwan} and Joo, {Kwon Wook} and Kim, {Yon Su} and Curie Ahn and Han, {Jin Suk} and Lee, {Kyu Beck} and Kim, {Yoon Goo} and Lee, {Jung Eun} and Lee, {Sang Koo}",
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TY - JOUR

T1 - The mildly elevated serum bilirubin level is negatively associated with the incidence of end stage Renal disease in patients with IgA nephropathy

AU - Chin, Ho Jun

AU - Cho, Hyun Jin

AU - Lee, Tae Woo

AU - Na, Ki Young

AU - Oh, Kook Hwan

AU - Joo, Kwon Wook

AU - Yoon, Hyung Jin

AU - Kim, Yon Su

AU - Ahn, Curie

AU - Han, Jin Suk

AU - Kim, Suhnggwon

AU - Jeon, En Sil

AU - Jin, Dong Chan

AU - Kim, Yong Lim

AU - Park, Sun Hee

AU - Kim, Chan Duck

AU - Song, Young Rim

AU - Kim, Seong Gyun

AU - Kim, Yoon Goo

AU - Lee, Jung Eun

AU - Oh, Yoon Kyu

AU - Lim, Chun Soo

AU - Lee, Sang Koo

AU - Chae, Dong Wan

AU - Cho, Won Yong

AU - Kim, Hyoung Kyu

AU - Jo, Sang Kyung

AU - Jang, Eun Hee

AU - Kim, Won

AU - Kim, Nam Ho

AU - Bae, Woo Kyun

AU - Kim, Hye Young

AU - Ahn, Ki Sung

AU - Cho, Jong Tae

AU - Lee, Eun Kyeong

AU - Kim, Ki Hyun

AU - An, Won Suk

AU - Kim, Seong Eun

AU - Bog, Choi Gyu

AU - Kim, Seung Jung

AU - Chung, Woo Kyung

AU - Lee, Hyun Hee

AU - Yang, Jaeseok

AU - Kim, Sejoong

AU - Chang, Se Ho

AU - Noh, Jung Woo

AU - Lee, Young Ki

AU - Kim, Seong Gyun

AU - Oh, Jieun

AU - Song, Young Rim

AU - Kim, Moon Jae

AU - Lee, Seoung Woo

AU - Kim, Yeong Hoon

AU - Park, Won Do

AU - Kim, Hyun Chul

AU - Park, Sung Bae

AU - Kim, Kyo Soon

AU - Cho, Won Yong

AU - Kim, Hyoung Kyu

AU - Jo, Sang Kyung

AU - Cha, Dae-Ryong

AU - Kang, Young Sun

AU - Kwon, Young-Joo

AU - Kim, Yong Lim

AU - Park, Sun Hee

AU - Kim, Chan Duck

AU - Yang, Dong Ho

AU - Kwak, Ihm Soo

AU - Lee, Soo Bong

AU - Lee, Dong Won

AU - Song, Sang Heon

AU - Seoung, Eun Young

AU - Yoon, Su Jin

AU - Lim, Chun Soo

AU - Oh, Yoon Kyu

AU - Oh, Kook Hwan

AU - Joo, Kwon Wook

AU - Kim, Yon Su

AU - Ahn, Curie

AU - Han, Jin Suk

AU - Lee, Kyu Beck

AU - Kim, Yoon Goo

AU - Lee, Jung Eun

AU - Lee, Sang Koo

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Oxidative stress plays various roles in the development and progression of IgA nephropathy, while bilirubin is known as a potent antioxidant. We therefore hypothesized that serum bilirubin would be associated with renal prognosis in IgA nephropathy. The study subjects comprised 1,458 adult patients with primary IgA nephropathy in Korea. We grouped patients according to the following quartile levels of bilirubin: <0.4 mg/dL (Q1), 0.4-0.5 mg/dL (Q2), 0.6-0.7 mg/dL (Q3), and >0.8 mg/dL (Q4). The outcome data were obtained from the Korean Registry of end-stage renal disease (ESRD). Eighty patients (5.5%) contracted ESRD during a mean follow-up period of 44.9 months. The ESRD incidences were 10.7% in Q1, 8.2% in Q2, 2.8% in Q3, and 2.8% in Q4 (p<0.001). The relative risk of ESRD compared to that in Q1 was 0.307 (95% confidence interval [CI], 0.126-0.751) in Q3 and 0.315 (95% CI, 0.130-0.765) in Q4. The differences of ESRD incidence were greater in subgroups of males and of patients aged 35 yr or more, with serum albumin 4.0 g/dL or more, with normotension, with eGFR 60 mL/min/1.73 m2 or more, and with proteinuria less then 3+ by dipstick test. In conclusion, higher bilirubin level was negatively associated with ESRD incidence in IgA nephropathy.

AB - Oxidative stress plays various roles in the development and progression of IgA nephropathy, while bilirubin is known as a potent antioxidant. We therefore hypothesized that serum bilirubin would be associated with renal prognosis in IgA nephropathy. The study subjects comprised 1,458 adult patients with primary IgA nephropathy in Korea. We grouped patients according to the following quartile levels of bilirubin: <0.4 mg/dL (Q1), 0.4-0.5 mg/dL (Q2), 0.6-0.7 mg/dL (Q3), and >0.8 mg/dL (Q4). The outcome data were obtained from the Korean Registry of end-stage renal disease (ESRD). Eighty patients (5.5%) contracted ESRD during a mean follow-up period of 44.9 months. The ESRD incidences were 10.7% in Q1, 8.2% in Q2, 2.8% in Q3, and 2.8% in Q4 (p<0.001). The relative risk of ESRD compared to that in Q1 was 0.307 (95% confidence interval [CI], 0.126-0.751) in Q3 and 0.315 (95% CI, 0.130-0.765) in Q4. The differences of ESRD incidence were greater in subgroups of males and of patients aged 35 yr or more, with serum albumin 4.0 g/dL or more, with normotension, with eGFR 60 mL/min/1.73 m2 or more, and with proteinuria less then 3+ by dipstick test. In conclusion, higher bilirubin level was negatively associated with ESRD incidence in IgA nephropathy.

KW - Bilirubin

KW - Chronic

KW - Glomerulonephritis

KW - IGA

KW - Kidney failure

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U2 - 10.3346/jkms.2009.24.S1.S22

DO - 10.3346/jkms.2009.24.S1.S22

M3 - Article

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JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - SUPPL.1

ER -