The mildly elevated serum bilirubin level is negatively associated with the incidence of end stage Renal disease in patients with IgA nephropathy

Ho Jun Chin, Hyun Jin Cho, Tae Woo Lee, Ki Young Na, Kook Hwan Oh, Kwon Wook Joo, Hyung Jin Yoon, Yon Su Kim, Curie Ahn, Jin Suk Han, Suhnggwon Kim, En Sil Jeon, Dong Chan Jin, Yong Lim Kim, Sun Hee Park, Chan Duck Kim, Young Rim Song, Seong Gyun Kim, Yoon Goo Kim, Jung Eun LeeYoon Kyu Oh, Chun Soo Lim, Sang Koo Lee, Dong Wan Chae, Won Yong Cho, Hyoung Kyu Kim, Sang Kyung Jo, Eun Hee Jang, Won Kim, Nam Ho Kim, Woo Kyun Bae, Hye Young Kim, Ki Sung Ahn, Jong Tae Cho, Eun Kyeong Lee, Ki Hyun Kim, Won Suk An, Seong Eun Kim, Choi Gyu Bog, Seung Jung Kim, Woo Kyung Chung, Hyun Hee Lee, Jaeseok Yang, Sejoong Kim, Se Ho Chang, Jung Woo Noh, Young Ki Lee, Seong Gyun Kim, Jieun Oh, Young Rim Song, Moon Jae Kim, Seoung Woo Lee, Yeong Hoon Kim, Won Do Park, Hyun Chul Kim, Sung Bae Park, Kyo Soon Kim, Won Yong Cho, Hyoung Kyu Kim, Sang Kyung Jo, Cha Dae Ryong, Kang Young Sun, Young Joo Kwon, Yong Lim Kim, Sun Hee Park, Chan Duck Kim, Dong Ho Yang, Ihm Soo Kwak, Soo Bong Lee, Dong Won Lee, Sang Heon Song, Eun Young Seoung, Su Jin Yoon, Chun Soo Lim, Yoon Kyu Oh, Kook Hwan Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn, Jin Suk Han, Kyu Beck Lee, Yoon Goo Kim, Jung Eun Lee, Sang Koo Lee

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Oxidative stress plays various roles in the development and progression of IgA nephropathy, while bilirubin is known as a potent antioxidant. We therefore hypothesized that serum bilirubin would be associated with renal prognosis in IgA nephropathy. The study subjects comprised 1,458 adult patients with primary IgA nephropathy in Korea. We grouped patients according to the following quartile levels of bilirubin: <0.4 mg/dL (Q1), 0.4-0.5 mg/dL (Q2), 0.6-0.7 mg/dL (Q3), and >0.8 mg/dL (Q4). The outcome data were obtained from the Korean Registry of end-stage renal disease (ESRD). Eighty patients (5.5%) contracted ESRD during a mean follow-up period of 44.9 months. The ESRD incidences were 10.7% in Q1, 8.2% in Q2, 2.8% in Q3, and 2.8% in Q4 (p<0.001). The relative risk of ESRD compared to that in Q1 was 0.307 (95% confidence interval [CI], 0.126-0.751) in Q3 and 0.315 (95% CI, 0.130-0.765) in Q4. The differences of ESRD incidence were greater in subgroups of males and of patients aged 35 yr or more, with serum albumin 4.0 g/dL or more, with normotension, with eGFR 60 mL/min/1.73 m2 or more, and with proteinuria less then 3+ by dipstick test. In conclusion, higher bilirubin level was negatively associated with ESRD incidence in IgA nephropathy.

Original languageEnglish
Pages (from-to)S22-S29
JournalJournal of Korean medical science
Volume24
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2009

Keywords

  • Bilirubin
  • Chronic
  • Glomerulonephritis
  • IGA
  • Kidney failure

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'The mildly elevated serum bilirubin level is negatively associated with the incidence of end stage Renal disease in patients with IgA nephropathy'. Together they form a unique fingerprint.

Cite this