miR-146a-Polymorphismus und Anfälligkeit für systemischen Lupus erythematosus sowie rheumatoide Arthritis: Eine Metaanalyse

Translated title of the contribution: The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: A meta-analysis

Young Ho Lee, S. C. Bae

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: The aim of this study was to explore whether the miR-146a polymorphism (rs2910164) confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). Methods: A meta-analysis was conducted on the association of the miR-146a polymorphism with SLE and RA. Results: Five studies with 2013 patients and 2555 controls were included in the meta-analysis. Meta-analysis revealed no association between SLE and the miR-146a G allele (odds ratio, OR = 1.007, 95 % confidence interval, CI = 0.910–1.114, p = 0.888). Additionally, no associations were found between the miR-146a polymorphism and SLE using recessive or dominant models, or homozygote contrast. Meta-analysis using allele contrast, recessive and dominant models, as well as homozygote contrast failed to reveal an association between the miR-146a polymorphism and RA (OR for G allele = 1.114, 95 % CI = 0.892–1.391, p = 0.342). Conclusion: This meta-analysis demonstrates that the miR-146a polymorphism is not associated with susceptibility to SLE and RA. However, considering the small number of studies, further studies are needed to confirm this result.

Translated title of the contributionThe miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: A meta-analysis
Original languageGerman
Pages (from-to)153-156
Number of pages4
JournalZeitschrift fur Rheumatologie
Volume74
Issue number2
DOIs
Publication statusPublished - 2015 Mar 1

Keywords

  • Autoimmune disease
  • Ethnicity
  • Inflammatory disease
  • MicroRNAs
  • Polymorphism, single nucleotide

ASJC Scopus subject areas

  • Rheumatology

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