miR-146a-Polymorphismus und Anfälligkeit für systemischen Lupus erythematosus sowie rheumatoide Arthritis: Eine Metaanalyse

Translated title of the contribution: The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: A meta-analysis

Young Ho Lee, S. C. Bae

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: The aim of this study was to explore whether the miR-146a polymorphism (rs2910164) confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). Methods: A meta-analysis was conducted on the association of the miR-146a polymorphism with SLE and RA. Results: Five studies with 2013 patients and 2555 controls were included in the meta-analysis. Meta-analysis revealed no association between SLE and the miR-146a G allele (odds ratio, OR = 1.007, 95 % confidence interval, CI = 0.910–1.114, p = 0.888). Additionally, no associations were found between the miR-146a polymorphism and SLE using recessive or dominant models, or homozygote contrast. Meta-analysis using allele contrast, recessive and dominant models, as well as homozygote contrast failed to reveal an association between the miR-146a polymorphism and RA (OR for G allele = 1.114, 95 % CI = 0.892–1.391, p = 0.342). Conclusion: This meta-analysis demonstrates that the miR-146a polymorphism is not associated with susceptibility to SLE and RA. However, considering the small number of studies, further studies are needed to confirm this result.

Original languageGerman
Pages (from-to)153-156
Number of pages4
JournalZeitschrift fur Rheumatologie
Volume74
Issue number2
DOIs
Publication statusPublished - 2015 Mar 1

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Systemic Lupus Erythematosus
Meta-Analysis
Rheumatoid Arthritis
Homozygote
Alleles
Odds Ratio
Confidence Intervals

Keywords

  • Autoimmune disease
  • Ethnicity
  • Inflammatory disease
  • MicroRNAs
  • Polymorphism, single nucleotide

ASJC Scopus subject areas

  • Rheumatology

Cite this

miR-146a-Polymorphismus und Anfälligkeit für systemischen Lupus erythematosus sowie rheumatoide Arthritis : Eine Metaanalyse. / Lee, Young Ho; Bae, S. C.

In: Zeitschrift fur Rheumatologie, Vol. 74, No. 2, 01.03.2015, p. 153-156.

Research output: Contribution to journalArticle

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abstract = "Objective: The aim of this study was to explore whether the miR-146a polymorphism (rs2910164) confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). Methods: A meta-analysis was conducted on the association of the miR-146a polymorphism with SLE and RA. Results: Five studies with 2013 patients and 2555 controls were included in the meta-analysis. Meta-analysis revealed no association between SLE and the miR-146a G allele (odds ratio, OR = 1.007, 95 {\%} confidence interval, CI = 0.910–1.114, p = 0.888). Additionally, no associations were found between the miR-146a polymorphism and SLE using recessive or dominant models, or homozygote contrast. Meta-analysis using allele contrast, recessive and dominant models, as well as homozygote contrast failed to reveal an association between the miR-146a polymorphism and RA (OR for G allele = 1.114, 95 {\%} CI = 0.892–1.391, p = 0.342). Conclusion: This meta-analysis demonstrates that the miR-146a polymorphism is not associated with susceptibility to SLE and RA. However, considering the small number of studies, further studies are needed to confirm this result.",
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