Abstract
The study aimed to develop a computational method for assessing relative changes in compartmental compliances within the brain: the arterial bed and the cerebrospinal space. The method utilizes the relationship between pulsatile components in the arterial blood volume, arterial blood pressure (ABP) and intracranial pressure (ICP). It was verified by using clinical recordings of intracranial pressure plateau waves, when massive vasodilatation accompanying plateau waves produces changes in brain compliances of the arterial bed (C a) and compliance of the cerebrospinal space (Ci). Ten patients admitted after head injury with a median Glasgow Coma Score of 6 were studied retrospectively. ABP was directly monitored from the radial artery. Changes in the cerebral arterial blood volume were assessed using Transcranial Doppler (TCD) ultrasonography by digital integration of inflow blood velocity. During plateau waves, ICP increased (P = 0.001), CPP decreased (P = 0.001), ABP remained constant (P = 0.532), blood flow velocity decreased (P = 0.001). Calculated compliance of the arterial bed Ca increased significantly (P = 0.001); compliance of the CSF space Ci decreased (P = 0.001). We concluded that the method allows for continuous monitoring of relative changes in brain compartmental compliances. Plateau waves affect the balance between vascular and CSF compartments, which is reflected by the inverse change of compliance of the cerebral arterial bed and global compliance of the CSF space.
| Original language | English |
|---|---|
| Pages (from-to) | 647-659 |
| Number of pages | 13 |
| Journal | Physiological Measurement |
| Volume | 30 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2009 Nov 4 |
| Externally published | Yes |
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Keywords
- Arterial bed compliance
- Brain
- Brain compartmental compliance
- Cerebral blood flow
- CSF space compliance
- Intracranial pressure
- TCD monitoring
ASJC Scopus subject areas
- Biophysics
- Physiology
- Physiology (medical)
Cite this
The monitoring of relative changes in compartmental compliances of brain. / Kim, Dong Ju; Kasprowicz, Magdalena; Carrera, Emmanuel; Castellani, Gianluca; Zweifel, Christian; Lavinio, Andrea; Smielewski, Peter; Sutcliffe, Michael P F; Pickard, John D.; Czosnyka, Marek.
In: Physiological Measurement, Vol. 30, No. 7, 04.11.2009, p. 647-659.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The monitoring of relative changes in compartmental compliances of brain
AU - Kim, Dong Ju
AU - Kasprowicz, Magdalena
AU - Carrera, Emmanuel
AU - Castellani, Gianluca
AU - Zweifel, Christian
AU - Lavinio, Andrea
AU - Smielewski, Peter
AU - Sutcliffe, Michael P F
AU - Pickard, John D.
AU - Czosnyka, Marek
PY - 2009/11/4
Y1 - 2009/11/4
N2 - The study aimed to develop a computational method for assessing relative changes in compartmental compliances within the brain: the arterial bed and the cerebrospinal space. The method utilizes the relationship between pulsatile components in the arterial blood volume, arterial blood pressure (ABP) and intracranial pressure (ICP). It was verified by using clinical recordings of intracranial pressure plateau waves, when massive vasodilatation accompanying plateau waves produces changes in brain compliances of the arterial bed (C a) and compliance of the cerebrospinal space (Ci). Ten patients admitted after head injury with a median Glasgow Coma Score of 6 were studied retrospectively. ABP was directly monitored from the radial artery. Changes in the cerebral arterial blood volume were assessed using Transcranial Doppler (TCD) ultrasonography by digital integration of inflow blood velocity. During plateau waves, ICP increased (P = 0.001), CPP decreased (P = 0.001), ABP remained constant (P = 0.532), blood flow velocity decreased (P = 0.001). Calculated compliance of the arterial bed Ca increased significantly (P = 0.001); compliance of the CSF space Ci decreased (P = 0.001). We concluded that the method allows for continuous monitoring of relative changes in brain compartmental compliances. Plateau waves affect the balance between vascular and CSF compartments, which is reflected by the inverse change of compliance of the cerebral arterial bed and global compliance of the CSF space.
AB - The study aimed to develop a computational method for assessing relative changes in compartmental compliances within the brain: the arterial bed and the cerebrospinal space. The method utilizes the relationship between pulsatile components in the arterial blood volume, arterial blood pressure (ABP) and intracranial pressure (ICP). It was verified by using clinical recordings of intracranial pressure plateau waves, when massive vasodilatation accompanying plateau waves produces changes in brain compliances of the arterial bed (C a) and compliance of the cerebrospinal space (Ci). Ten patients admitted after head injury with a median Glasgow Coma Score of 6 were studied retrospectively. ABP was directly monitored from the radial artery. Changes in the cerebral arterial blood volume were assessed using Transcranial Doppler (TCD) ultrasonography by digital integration of inflow blood velocity. During plateau waves, ICP increased (P = 0.001), CPP decreased (P = 0.001), ABP remained constant (P = 0.532), blood flow velocity decreased (P = 0.001). Calculated compliance of the arterial bed Ca increased significantly (P = 0.001); compliance of the CSF space Ci decreased (P = 0.001). We concluded that the method allows for continuous monitoring of relative changes in brain compartmental compliances. Plateau waves affect the balance between vascular and CSF compartments, which is reflected by the inverse change of compliance of the cerebral arterial bed and global compliance of the CSF space.
KW - Arterial bed compliance
KW - Brain
KW - Brain compartmental compliance
KW - Cerebral blood flow
KW - CSF space compliance
KW - Intracranial pressure
KW - TCD monitoring
UR - http://www.scopus.com/inward/record.url?scp=70249123911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70249123911&partnerID=8YFLogxK
U2 - 10.1088/0967-3334/30/7/009
DO - 10.1088/0967-3334/30/7/009
M3 - Article
C2 - 19498218
AN - SCOPUS:70249123911
VL - 30
SP - 647
EP - 659
JO - Physiological Measurement
JF - Physiological Measurement
SN - 0967-3334
IS - 7
ER -