The monitoring of relative changes in compartmental compliances of brain

Dong Ju Kim, Magdalena Kasprowicz, Emmanuel Carrera, Gianluca Castellani, Christian Zweifel, Andrea Lavinio, Peter Smielewski, Michael P F Sutcliffe, John D. Pickard, Marek Czosnyka

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The study aimed to develop a computational method for assessing relative changes in compartmental compliances within the brain: the arterial bed and the cerebrospinal space. The method utilizes the relationship between pulsatile components in the arterial blood volume, arterial blood pressure (ABP) and intracranial pressure (ICP). It was verified by using clinical recordings of intracranial pressure plateau waves, when massive vasodilatation accompanying plateau waves produces changes in brain compliances of the arterial bed (C a) and compliance of the cerebrospinal space (Ci). Ten patients admitted after head injury with a median Glasgow Coma Score of 6 were studied retrospectively. ABP was directly monitored from the radial artery. Changes in the cerebral arterial blood volume were assessed using Transcranial Doppler (TCD) ultrasonography by digital integration of inflow blood velocity. During plateau waves, ICP increased (P = 0.001), CPP decreased (P = 0.001), ABP remained constant (P = 0.532), blood flow velocity decreased (P = 0.001). Calculated compliance of the arterial bed Ca increased significantly (P = 0.001); compliance of the CSF space Ci decreased (P = 0.001). We concluded that the method allows for continuous monitoring of relative changes in brain compartmental compliances. Plateau waves affect the balance between vascular and CSF compartments, which is reflected by the inverse change of compliance of the cerebral arterial bed and global compliance of the CSF space.

Original languageEnglish
Pages (from-to)647-659
Number of pages13
JournalPhysiological Measurement
Volume30
Issue number7
DOIs
Publication statusPublished - 2009 Nov 4
Externally publishedYes

Fingerprint

Compliance
Intracranial Pressure
Brain
Arterial Pressure
Doppler Transcranial Ultrasonography
Radial Artery
Blood Flow Velocity
Coma
Blood Volume
Craniocerebral Trauma
Vasodilation
Blood Vessels

Keywords

  • Arterial bed compliance
  • Brain
  • Brain compartmental compliance
  • Cerebral blood flow
  • CSF space compliance
  • Intracranial pressure
  • TCD monitoring

ASJC Scopus subject areas

  • Biophysics
  • Physiology
  • Physiology (medical)

Cite this

Kim, D. J., Kasprowicz, M., Carrera, E., Castellani, G., Zweifel, C., Lavinio, A., ... Czosnyka, M. (2009). The monitoring of relative changes in compartmental compliances of brain. Physiological Measurement, 30(7), 647-659. https://doi.org/10.1088/0967-3334/30/7/009

The monitoring of relative changes in compartmental compliances of brain. / Kim, Dong Ju; Kasprowicz, Magdalena; Carrera, Emmanuel; Castellani, Gianluca; Zweifel, Christian; Lavinio, Andrea; Smielewski, Peter; Sutcliffe, Michael P F; Pickard, John D.; Czosnyka, Marek.

In: Physiological Measurement, Vol. 30, No. 7, 04.11.2009, p. 647-659.

Research output: Contribution to journalArticle

Kim, DJ, Kasprowicz, M, Carrera, E, Castellani, G, Zweifel, C, Lavinio, A, Smielewski, P, Sutcliffe, MPF, Pickard, JD & Czosnyka, M 2009, 'The monitoring of relative changes in compartmental compliances of brain', Physiological Measurement, vol. 30, no. 7, pp. 647-659. https://doi.org/10.1088/0967-3334/30/7/009
Kim DJ, Kasprowicz M, Carrera E, Castellani G, Zweifel C, Lavinio A et al. The monitoring of relative changes in compartmental compliances of brain. Physiological Measurement. 2009 Nov 4;30(7):647-659. https://doi.org/10.1088/0967-3334/30/7/009
Kim, Dong Ju ; Kasprowicz, Magdalena ; Carrera, Emmanuel ; Castellani, Gianluca ; Zweifel, Christian ; Lavinio, Andrea ; Smielewski, Peter ; Sutcliffe, Michael P F ; Pickard, John D. ; Czosnyka, Marek. / The monitoring of relative changes in compartmental compliances of brain. In: Physiological Measurement. 2009 ; Vol. 30, No. 7. pp. 647-659.
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