The multifaceted actions of PTHrP in skeletal metastasis

Fabiana N. Soki, Serkin Park, Laurie K. McCauley

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

PTHrP, identified during the elucidation of mediators of malignancy-induced hypercalcemia, plays numerous roles in normal physiology as well as pathological conditions. Recent data support direct functions of PTHrP in metastasis, particularly from tumors with strong bone tropism. Bone provides a unique metastatic environment because of mineralization and the diverse cell populations in the bone marrow. PTHrP is a key regulator of tumor-bone interactions and regulates cells in the bone microenvironment through proliferative and prosurvival activities that prime the 'seed and the 'soil of the metastatic lesion. This review highlights recent findings regarding the role of PTHrP in skeletal metastasis, including direct actions in tumor cells, as well as alterations in the bone microenvironment and future perspectives involving the potential roles of PTHrP in the premetastatic niche, and tumor dormancy.

Original languageEnglish
Pages (from-to)803-817
Number of pages15
JournalFuture Oncology
Volume8
Issue number7
DOIs
Publication statusPublished - 2012 Jul 1
Externally publishedYes

Fingerprint

Parathyroid Hormone-Related Protein
Neoplasm Metastasis
Bone and Bones
Neoplasms
Tropism
Hypercalcemia
Cell Communication
Seeds
Soil
Bone Marrow
Population

Keywords

  • bone
  • breast cancer
  • metastasis
  • parathyroid hormone-related protein
  • premetastatic niche
  • prostate cancer
  • PTHrP

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The multifaceted actions of PTHrP in skeletal metastasis. / Soki, Fabiana N.; Park, Serkin; McCauley, Laurie K.

In: Future Oncology, Vol. 8, No. 7, 01.07.2012, p. 803-817.

Research output: Contribution to journalReview article

Soki, Fabiana N. ; Park, Serkin ; McCauley, Laurie K. / The multifaceted actions of PTHrP in skeletal metastasis. In: Future Oncology. 2012 ; Vol. 8, No. 7. pp. 803-817.
@article{361e0bd98eb1459cbe8bbece88974bfc,
title = "The multifaceted actions of PTHrP in skeletal metastasis",
abstract = "PTHrP, identified during the elucidation of mediators of malignancy-induced hypercalcemia, plays numerous roles in normal physiology as well as pathological conditions. Recent data support direct functions of PTHrP in metastasis, particularly from tumors with strong bone tropism. Bone provides a unique metastatic environment because of mineralization and the diverse cell populations in the bone marrow. PTHrP is a key regulator of tumor-bone interactions and regulates cells in the bone microenvironment through proliferative and prosurvival activities that prime the 'seed and the 'soil of the metastatic lesion. This review highlights recent findings regarding the role of PTHrP in skeletal metastasis, including direct actions in tumor cells, as well as alterations in the bone microenvironment and future perspectives involving the potential roles of PTHrP in the premetastatic niche, and tumor dormancy.",
keywords = "bone, breast cancer, metastasis, parathyroid hormone-related protein, premetastatic niche, prostate cancer, PTHrP",
author = "Soki, {Fabiana N.} and Serkin Park and McCauley, {Laurie K.}",
year = "2012",
month = "7",
day = "1",
doi = "10.2217/fon.12.76",
language = "English",
volume = "8",
pages = "803--817",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "7",

}

TY - JOUR

T1 - The multifaceted actions of PTHrP in skeletal metastasis

AU - Soki, Fabiana N.

AU - Park, Serkin

AU - McCauley, Laurie K.

PY - 2012/7/1

Y1 - 2012/7/1

N2 - PTHrP, identified during the elucidation of mediators of malignancy-induced hypercalcemia, plays numerous roles in normal physiology as well as pathological conditions. Recent data support direct functions of PTHrP in metastasis, particularly from tumors with strong bone tropism. Bone provides a unique metastatic environment because of mineralization and the diverse cell populations in the bone marrow. PTHrP is a key regulator of tumor-bone interactions and regulates cells in the bone microenvironment through proliferative and prosurvival activities that prime the 'seed and the 'soil of the metastatic lesion. This review highlights recent findings regarding the role of PTHrP in skeletal metastasis, including direct actions in tumor cells, as well as alterations in the bone microenvironment and future perspectives involving the potential roles of PTHrP in the premetastatic niche, and tumor dormancy.

AB - PTHrP, identified during the elucidation of mediators of malignancy-induced hypercalcemia, plays numerous roles in normal physiology as well as pathological conditions. Recent data support direct functions of PTHrP in metastasis, particularly from tumors with strong bone tropism. Bone provides a unique metastatic environment because of mineralization and the diverse cell populations in the bone marrow. PTHrP is a key regulator of tumor-bone interactions and regulates cells in the bone microenvironment through proliferative and prosurvival activities that prime the 'seed and the 'soil of the metastatic lesion. This review highlights recent findings regarding the role of PTHrP in skeletal metastasis, including direct actions in tumor cells, as well as alterations in the bone microenvironment and future perspectives involving the potential roles of PTHrP in the premetastatic niche, and tumor dormancy.

KW - bone

KW - breast cancer

KW - metastasis

KW - parathyroid hormone-related protein

KW - premetastatic niche

KW - prostate cancer

KW - PTHrP

UR - http://www.scopus.com/inward/record.url?scp=84864453110&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864453110&partnerID=8YFLogxK

U2 - 10.2217/fon.12.76

DO - 10.2217/fon.12.76

M3 - Review article

VL - 8

SP - 803

EP - 817

JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

IS - 7

ER -