The multifaceted actions of PTHrP in skeletal metastasis

Fabiana N. Soki, Serk In Park, Laurie K. McCauley

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

PTHrP, identified during the elucidation of mediators of malignancy-induced hypercalcemia, plays numerous roles in normal physiology as well as pathological conditions. Recent data support direct functions of PTHrP in metastasis, particularly from tumors with strong bone tropism. Bone provides a unique metastatic environment because of mineralization and the diverse cell populations in the bone marrow. PTHrP is a key regulator of tumor-bone interactions and regulates cells in the bone microenvironment through proliferative and prosurvival activities that prime the 'seed and the 'soil of the metastatic lesion. This review highlights recent findings regarding the role of PTHrP in skeletal metastasis, including direct actions in tumor cells, as well as alterations in the bone microenvironment and future perspectives involving the potential roles of PTHrP in the premetastatic niche, and tumor dormancy.

Original languageEnglish
Pages (from-to)803-817
Number of pages15
JournalFuture Oncology
Volume8
Issue number7
DOIs
Publication statusPublished - 2012 Jul 1
Externally publishedYes

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Keywords

  • PTHrP
  • bone
  • breast cancer
  • metastasis
  • parathyroid hormone-related protein
  • premetastatic niche
  • prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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