The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment

Geon Ha Kim, Sang Won Seo, Kihyo Jung, Oh Hun Kwon, Hunki Kwon, Jong Hun Kim, Jee Hoon Roh, Min Jeong Kim, Byung Hwa Lee, Doo Sang Yoon, Jung Won Hwang, Jong Min Lee, Jee Hyang Jeong, Heecheon You, Kenneth M. Heilman, Duk L. Na

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Subcortical vascular cognitive impairment (SVCI) refers to cognitive impairment associated with small vessel disease. Motor intentional disorders (MID) have been reported in patients with SVCI. However, there are no studies exploring the neuroanatomical regions related to MID in SVCI patients. The aim of this study, therefore, was to investigate the neural correlates of MID in SVCI patients. Thirty-one patients with SVCI as well as 10 healthy match control participants were included. A “Pinch-Grip” apparatus was used to quantify the force control capabilities of the index finger in four different movement phases including initiation, development, maintenance, and termination. All participants underwent magnetic resonance imaging (MRI). Topographical cortical areas and white matter tracts correlated with the performances of the four different movement phases were assessed by the surface-based morphometry and tract-based spatial statistics analyses. Poorer performance in the maintenance task was related to cortical thinning in bilateral dorsolateral prefrontal, orbitofrontal and parietal cortices, while poorer performance in the termination task was associated with the disruption of fronto-parietal cortical areas as well as the white matter tracts including splenium and association fibers such as superior longitudinal fasciculus. Our study demonstrates that cortical areas and underlying white matter tracts associated with fronto-parietal attentional system play an important role in motor impersistence and perseveration in SVCI patients.

Original languageEnglish
Pages (from-to)89-99
Number of pages11
JournalJournal of Neurology
Volume263
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

Keywords

  • Cortical thickness
  • Motor intentional disorder
  • Subcortical vascular cognitive impairment
  • Tract-based spatial statistics

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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