The neuroprotective effects of traditional oriental herbal medicines against β-amyloid-induced toxicity

So Young Park, Hyo Shin Kim, Seong Su Hong, Dong Geun Sul, Kwang Woo Hwang, Dongho Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is the most common form of dementia among the elderly, causing progressive cognitive dysfunction, particularly memory loss. Recently, modulation of Aβ toxicity, which is one of the major potential causes of AD, by plant extracts is emerging as a possible therapeutic approach to control the onset of AD. Therefore, in the present study, the methanol extracts of 400 traditional oriental herbal medicines were tested for their abilities to protect PC12 rat pheochromocytoma cells against Aβ-induced toxicity. Our results identified 29 plant extracts that protected PC12 cells against Aβ insult, with ED50 values of less than 100 μg/mL. Among these extracts, those from Chaenomeles sinensis Koehne (Rosaceae), Ephedra sinica Stapf. (Ephedraceae), and Drynaria fortunei Smith (Polypodiaceae) exhibited the most promising neuroprotective effects, with ED50 values of less than 10 μg/mL. Their neuroprotective effects against Aβ insult were not fully explained by their participation in antioxidant pathways, as demonstrated by a free radical scavenging assay with DPPH. Therefore, the mechanisms and the major constituents behind the neuroprotective effects of these plant extracts warrant further study.

Original languageEnglish
Pages (from-to)976-981
Number of pages6
JournalPharmaceutical Biology
Volume47
Issue number10
DOIs
Publication statusPublished - 2009 Oct 1

Fingerprint

East Asian Traditional Medicine
Herbal Medicine
Polypodiaceae
Plant Extracts
Neuroprotective Agents
Amyloid
Rosaceae
Alzheimer Disease
Ephedra sinica
Aptitude
PC12 Cells
Memory Disorders
Pheochromocytoma
Free Radicals
Methanol
Dementia
Antioxidants
Therapeutics

Keywords

  • β-amyloid-induced neurotoxicity
  • Anti-Alzheimer's agent
  • Antioxidant effect
  • Chaenomeles sinensis Koehne
  • Drynaria fortunei Smith
  • Ephedra sinica Stapf.
  • Traditional oriental herbal medicines

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Complementary and alternative medicine
  • Molecular Medicine

Cite this

The neuroprotective effects of traditional oriental herbal medicines against β-amyloid-induced toxicity. / Park, So Young; Kim, Hyo Shin; Hong, Seong Su; Sul, Dong Geun; Hwang, Kwang Woo; Lee, Dongho.

In: Pharmaceutical Biology, Vol. 47, No. 10, 01.10.2009, p. 976-981.

Research output: Contribution to journalArticle

Park, So Young ; Kim, Hyo Shin ; Hong, Seong Su ; Sul, Dong Geun ; Hwang, Kwang Woo ; Lee, Dongho. / The neuroprotective effects of traditional oriental herbal medicines against β-amyloid-induced toxicity. In: Pharmaceutical Biology. 2009 ; Vol. 47, No. 10. pp. 976-981.
@article{5f2305646d8b4cccaf5bed9afba02afe,
title = "The neuroprotective effects of traditional oriental herbal medicines against β-amyloid-induced toxicity",
abstract = "Alzheimer's disease (AD) is the most common form of dementia among the elderly, causing progressive cognitive dysfunction, particularly memory loss. Recently, modulation of Aβ toxicity, which is one of the major potential causes of AD, by plant extracts is emerging as a possible therapeutic approach to control the onset of AD. Therefore, in the present study, the methanol extracts of 400 traditional oriental herbal medicines were tested for their abilities to protect PC12 rat pheochromocytoma cells against Aβ-induced toxicity. Our results identified 29 plant extracts that protected PC12 cells against Aβ insult, with ED50 values of less than 100 μg/mL. Among these extracts, those from Chaenomeles sinensis Koehne (Rosaceae), Ephedra sinica Stapf. (Ephedraceae), and Drynaria fortunei Smith (Polypodiaceae) exhibited the most promising neuroprotective effects, with ED50 values of less than 10 μg/mL. Their neuroprotective effects against Aβ insult were not fully explained by their participation in antioxidant pathways, as demonstrated by a free radical scavenging assay with DPPH. Therefore, the mechanisms and the major constituents behind the neuroprotective effects of these plant extracts warrant further study.",
keywords = "β-amyloid-induced neurotoxicity, Anti-Alzheimer's agent, Antioxidant effect, Chaenomeles sinensis Koehne, Drynaria fortunei Smith, Ephedra sinica Stapf., Traditional oriental herbal medicines",
author = "Park, {So Young} and Kim, {Hyo Shin} and Hong, {Seong Su} and Sul, {Dong Geun} and Hwang, {Kwang Woo} and Dongho Lee",
year = "2009",
month = "10",
day = "1",
doi = "10.1080/13880200902967987",
language = "English",
volume = "47",
pages = "976--981",
journal = "Pharmaceutical Biology",
issn = "1388-0209",
publisher = "Informa Healthcare",
number = "10",

}

TY - JOUR

T1 - The neuroprotective effects of traditional oriental herbal medicines against β-amyloid-induced toxicity

AU - Park, So Young

AU - Kim, Hyo Shin

AU - Hong, Seong Su

AU - Sul, Dong Geun

AU - Hwang, Kwang Woo

AU - Lee, Dongho

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Alzheimer's disease (AD) is the most common form of dementia among the elderly, causing progressive cognitive dysfunction, particularly memory loss. Recently, modulation of Aβ toxicity, which is one of the major potential causes of AD, by plant extracts is emerging as a possible therapeutic approach to control the onset of AD. Therefore, in the present study, the methanol extracts of 400 traditional oriental herbal medicines were tested for their abilities to protect PC12 rat pheochromocytoma cells against Aβ-induced toxicity. Our results identified 29 plant extracts that protected PC12 cells against Aβ insult, with ED50 values of less than 100 μg/mL. Among these extracts, those from Chaenomeles sinensis Koehne (Rosaceae), Ephedra sinica Stapf. (Ephedraceae), and Drynaria fortunei Smith (Polypodiaceae) exhibited the most promising neuroprotective effects, with ED50 values of less than 10 μg/mL. Their neuroprotective effects against Aβ insult were not fully explained by their participation in antioxidant pathways, as demonstrated by a free radical scavenging assay with DPPH. Therefore, the mechanisms and the major constituents behind the neuroprotective effects of these plant extracts warrant further study.

AB - Alzheimer's disease (AD) is the most common form of dementia among the elderly, causing progressive cognitive dysfunction, particularly memory loss. Recently, modulation of Aβ toxicity, which is one of the major potential causes of AD, by plant extracts is emerging as a possible therapeutic approach to control the onset of AD. Therefore, in the present study, the methanol extracts of 400 traditional oriental herbal medicines were tested for their abilities to protect PC12 rat pheochromocytoma cells against Aβ-induced toxicity. Our results identified 29 plant extracts that protected PC12 cells against Aβ insult, with ED50 values of less than 100 μg/mL. Among these extracts, those from Chaenomeles sinensis Koehne (Rosaceae), Ephedra sinica Stapf. (Ephedraceae), and Drynaria fortunei Smith (Polypodiaceae) exhibited the most promising neuroprotective effects, with ED50 values of less than 10 μg/mL. Their neuroprotective effects against Aβ insult were not fully explained by their participation in antioxidant pathways, as demonstrated by a free radical scavenging assay with DPPH. Therefore, the mechanisms and the major constituents behind the neuroprotective effects of these plant extracts warrant further study.

KW - β-amyloid-induced neurotoxicity

KW - Anti-Alzheimer's agent

KW - Antioxidant effect

KW - Chaenomeles sinensis Koehne

KW - Drynaria fortunei Smith

KW - Ephedra sinica Stapf.

KW - Traditional oriental herbal medicines

UR - http://www.scopus.com/inward/record.url?scp=77149153123&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77149153123&partnerID=8YFLogxK

U2 - 10.1080/13880200902967987

DO - 10.1080/13880200902967987

M3 - Article

VL - 47

SP - 976

EP - 981

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

SN - 1388-0209

IS - 10

ER -