The non-local bootstrap - Estimation of uncertainty in diffusion MRI

Pew Thian Yap, Hongyu An, Yasheng Chen, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Diffusion MRI is a noninvasive imaging modality that allows for the estimation and visualization of white matter connectivity patterns in the human brain. However, due to the low signal-to-noise ratio (SNR) nature of diffusion data, deriving useful statistics from the data is adversely affected by different sources of measurement noise. This is aggravated by the fact that the sampling distribution of the statistic of interest is often complex and unknown. In situations as such, the bootstrap, due to its distribution-independent nature, is an appealing tool for the estimation of the variability of almost any statistic, without relying on complicated theoretical calculations, but purely on computer simulation. In this work, we present new bootstrap strategies for variability estimation of diffusion statistics in association with noise. In contrast to the residual bootstrap, which relies on a predetermined data model, or the repetition bootstrap, which requires repeated signal measurements, our approach, called the non-local bootstrap (NLB), is non-parametric and obviates the need for time-consuming multiple acquisitions. The key assumption of NLB is that local image structures recur in the image. We exploit this self-similarity via a multivariate non-parametric kernel regression framework for bootstrap estimation of uncertainty. Evaluation of NLB using a set of high-resolution diffusion-weighted images, with lower than usual SNR due to the small voxel size, indicates that NLB is markedly more robust to noise and results in more accurate inferences.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages390-401
Number of pages12
Volume7917 LNCS
DOIs
Publication statusPublished - 2013 Jul 12
Externally publishedYes
Event23rd International Conference on Information Processing in Medical Imaging, IPMI 2013 - Asilomar, CA, United States
Duration: 2013 Jun 282013 Jul 3

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7917 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other23rd International Conference on Information Processing in Medical Imaging, IPMI 2013
CountryUnited States
CityAsilomar, CA
Period13/6/2813/7/3

Fingerprint

Magnetic resonance imaging
Bootstrap
Statistics
Uncertainty
Signal to noise ratio
Data structures
Brain
Statistic
Visualization
Sampling
Imaging techniques
Kernel Regression
Computer simulation
Sampling Distribution
Voxel
Nonparametric Regression
Self-similarity
Data Model
Modality
Connectivity

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

Cite this

Yap, P. T., An, H., Chen, Y., & Shen, D. (2013). The non-local bootstrap - Estimation of uncertainty in diffusion MRI. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 7917 LNCS, pp. 390-401). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 7917 LNCS). https://doi.org/10.1007/978-3-642-38868-2_33

The non-local bootstrap - Estimation of uncertainty in diffusion MRI. / Yap, Pew Thian; An, Hongyu; Chen, Yasheng; Shen, Dinggang.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 7917 LNCS 2013. p. 390-401 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 7917 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yap, PT, An, H, Chen, Y & Shen, D 2013, The non-local bootstrap - Estimation of uncertainty in diffusion MRI. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 7917 LNCS, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 7917 LNCS, pp. 390-401, 23rd International Conference on Information Processing in Medical Imaging, IPMI 2013, Asilomar, CA, United States, 13/6/28. https://doi.org/10.1007/978-3-642-38868-2_33
Yap PT, An H, Chen Y, Shen D. The non-local bootstrap - Estimation of uncertainty in diffusion MRI. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 7917 LNCS. 2013. p. 390-401. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-642-38868-2_33
Yap, Pew Thian ; An, Hongyu ; Chen, Yasheng ; Shen, Dinggang. / The non-local bootstrap - Estimation of uncertainty in diffusion MRI. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 7917 LNCS 2013. pp. 390-401 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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