TY - JOUR
T1 - The p120-v-Abl protein interacts with E2F-1 and regulates E2F-1 transcriptional activity
AU - Birchenall-Roberts, Maria C.
AU - Yoo, Young Do
AU - Bertolette, Daniel C.
AU - Lee, Kwan Hee
AU - Turley, Jennifer M.
AU - Bang, Ok Sun
AU - Ruscetti, Francis W.
AU - Kim, Seong Jin
PY - 1997/4/4
Y1 - 1997/4/4
N2 - The E2F family of transcription factors regulates cell cycle progression, and deregulated expression of E2F-1 can lead to neoplastic transformation. In myeloid cells, introduction and expression of the Abelson leukemia virus causes growth factor independence. Here, the p120 v-Abl protein activates E2F-1-mediated transcription through a physical interaction with the E2F-1 transcription factor. BCR-Abl and c-Abl also stimulate E2F-1- mediated transcription. Our results suggest a new mechanism by which v-Abl leads to factor-independent myeloid cell proliferation: the activation of E2F-1-mediated transcription.
AB - The E2F family of transcription factors regulates cell cycle progression, and deregulated expression of E2F-1 can lead to neoplastic transformation. In myeloid cells, introduction and expression of the Abelson leukemia virus causes growth factor independence. Here, the p120 v-Abl protein activates E2F-1-mediated transcription through a physical interaction with the E2F-1 transcription factor. BCR-Abl and c-Abl also stimulate E2F-1- mediated transcription. Our results suggest a new mechanism by which v-Abl leads to factor-independent myeloid cell proliferation: the activation of E2F-1-mediated transcription.
UR - http://www.scopus.com/inward/record.url?scp=1842289166&partnerID=8YFLogxK
U2 - 10.1074/jbc.272.14.8905
DO - 10.1074/jbc.272.14.8905
M3 - Article
C2 - 9083010
AN - SCOPUS:1842289166
SN - 0021-9258
VL - 272
SP - 8905
EP - 8911
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 14
ER -