The p120-v-Abl protein interacts with E2F-1 and regulates E2F-1 transcriptional activity

Maria C. Birchenall-Roberts, Young Do Yoo, Daniel C. Bertolette, Kwan H. Lee, Jennifer M. Turley, Ok S. Bang, Francis W. Ruscetti, Seong J. Kim

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Abstract

The E2F family of transcription factors regulates cell cycle progression, and deregulated expression of E2F-1 can lead to neoplastic transformation. In myeloid cells, introduction and expression of the Abelson leukemia virus causes growth factor independence. Here, the p120 v-Abl protein activates E2F-1-mediated transcription through a physical interaction with the E2F-1 transcription factor. BCR-Abl and c-Abl also stimulate E2F-1- mediated transcription. Our results suggest a new mechanism by which v-Abl leads to factor-independent myeloid cell proliferation: the activation of E2F-1-mediated transcription.

Original languageEnglish
Pages (from-to)8905-8911
Number of pages7
JournalJournal of Biological Chemistry
Volume272
Issue number14
DOIs
Publication statusPublished - 1997 Apr 4
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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    Birchenall-Roberts, M. C., Yoo, Y. D., Bertolette, D. C., Lee, K. H., Turley, J. M., Bang, O. S., Ruscetti, F. W., & Kim, S. J. (1997). The p120-v-Abl protein interacts with E2F-1 and regulates E2F-1 transcriptional activity. Journal of Biological Chemistry, 272(14), 8905-8911. https://doi.org/10.1074/jbc.272.14.8905