The p120-v-Abl protein interacts with E2F-1 and regulates E2F-1 transcriptional activity

Maria C. Birchenall-Roberts, Young Do Yoo, Daniel C. Bertolette, Kwan H. Lee, Jennifer M. Turley, Ok S. Bang, Francis W. Ruscetti, Seong J. Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The E2F family of transcription factors regulates cell cycle progression, and deregulated expression of E2F-1 can lead to neoplastic transformation. In myeloid cells, introduction and expression of the Abelson leukemia virus causes growth factor independence. Here, the p120 v-Abl protein activates E2F-1-mediated transcription through a physical interaction with the E2F-1 transcription factor. BCR-Abl and c-Abl also stimulate E2F-1- mediated transcription. Our results suggest a new mechanism by which v-Abl leads to factor-independent myeloid cell proliferation: the activation of E2F-1-mediated transcription.

Original languageEnglish
Pages (from-to)8905-8911
Number of pages7
JournalJournal of Biological Chemistry
Volume272
Issue number14
DOIs
Publication statusPublished - 1997 Apr 4
Externally publishedYes

Fingerprint

Oncogene Proteins v-abl
Myeloid Cells
Transcription
Abelson murine leukemia virus
E2F1 Transcription Factor
E2F Transcription Factors
Intercellular Signaling Peptides and Proteins
Cell Cycle
Cell Proliferation
Cell proliferation
Viruses
Transcription Factors
Chemical activation
Cells

ASJC Scopus subject areas

  • Biochemistry

Cite this

Birchenall-Roberts, M. C., Yoo, Y. D., Bertolette, D. C., Lee, K. H., Turley, J. M., Bang, O. S., ... Kim, S. J. (1997). The p120-v-Abl protein interacts with E2F-1 and regulates E2F-1 transcriptional activity. Journal of Biological Chemistry, 272(14), 8905-8911. https://doi.org/10.1074/jbc.272.14.8905

The p120-v-Abl protein interacts with E2F-1 and regulates E2F-1 transcriptional activity. / Birchenall-Roberts, Maria C.; Yoo, Young Do; Bertolette, Daniel C.; Lee, Kwan H.; Turley, Jennifer M.; Bang, Ok S.; Ruscetti, Francis W.; Kim, Seong J.

In: Journal of Biological Chemistry, Vol. 272, No. 14, 04.04.1997, p. 8905-8911.

Research output: Contribution to journalArticle

Birchenall-Roberts, MC, Yoo, YD, Bertolette, DC, Lee, KH, Turley, JM, Bang, OS, Ruscetti, FW & Kim, SJ 1997, 'The p120-v-Abl protein interacts with E2F-1 and regulates E2F-1 transcriptional activity', Journal of Biological Chemistry, vol. 272, no. 14, pp. 8905-8911. https://doi.org/10.1074/jbc.272.14.8905
Birchenall-Roberts, Maria C. ; Yoo, Young Do ; Bertolette, Daniel C. ; Lee, Kwan H. ; Turley, Jennifer M. ; Bang, Ok S. ; Ruscetti, Francis W. ; Kim, Seong J. / The p120-v-Abl protein interacts with E2F-1 and regulates E2F-1 transcriptional activity. In: Journal of Biological Chemistry. 1997 ; Vol. 272, No. 14. pp. 8905-8911.
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