The p120-v-Abl protein interacts with E2F-1 and regulates E2F-1 transcriptional activity

Maria C. Birchenall-Roberts, Young Do Yoo, Daniel C. Bertolette, Kwan Hee Lee, Jennifer M. Turley, Ok Sun Bang, Francis W. Ruscetti, Seong Jin Kim

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The E2F family of transcription factors regulates cell cycle progression, and deregulated expression of E2F-1 can lead to neoplastic transformation. In myeloid cells, introduction and expression of the Abelson leukemia virus causes growth factor independence. Here, the p120 v-Abl protein activates E2F-1-mediated transcription through a physical interaction with the E2F-1 transcription factor. BCR-Abl and c-Abl also stimulate E2F-1- mediated transcription. Our results suggest a new mechanism by which v-Abl leads to factor-independent myeloid cell proliferation: the activation of E2F-1-mediated transcription.

Original languageEnglish
Pages (from-to)8905-8911
Number of pages7
JournalJournal of Biological Chemistry
Volume272
Issue number14
DOIs
Publication statusPublished - 1997 Apr 4
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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