The perinuclear actin cap in health and disease

Shyam B. Khatau, Dong-Hwee Kim, Christopher M. Hale, Ryan J. Bloom, Denis Wirtz

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We recently demonstrated the existence of a previously uncharacterized subset of actomyosin fibers that form the perinuclear actin cap, a cytoskeletal structure that tightly wraps around the nucleus of a wide range of somatic cells. Fibers in the actin cap are distinct from well-characterized, conventional actin fibers at the basal and dorsal surfaces of adherent cells in their subcellular location, internal organization, dynamics, ability to generate contractile forces, response to cytoskeletal pharmacological treatments, response to biochemical stimuli, regulation by components of the linkers of nucleoskeleton and cytoskeleton (LINC) complexes, and response to disease-associated mutations in LMNA, the gene that encodes for the nuclear lamin component lamin A/C. The perinuclear actin cap precisely shapes the nucleus in interphase cells. The perinuclear actin cap may also be a mediator of microenvironment mechanosensing and mechanotransduction, as well as a regulator of cell motility, polarization and differentiation.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalNucleus
Volume1
Issue number4
DOIs
Publication statusPublished - 2010 Jan 1
Externally publishedYes

Fingerprint

Actins
Health
Lamins
Lamin Type A
Nuclear Matrix
Actomyosin
Interphase
Cytoskeleton
Cell Movement
Cell Differentiation
Pharmacology
Mutation
Genes

Keywords

  • Actin
  • Cancer
  • Cell shape
  • Laminopathies
  • LINC complexes
  • Nuclear lamina
  • Nucleus

ASJC Scopus subject areas

  • Cell Biology

Cite this

Khatau, S. B., Kim, D-H., Hale, C. M., Bloom, R. J., & Wirtz, D. (2010). The perinuclear actin cap in health and disease. Nucleus, 1(4), 337-342. https://doi.org/10.4161/nucl.1.4.12331

The perinuclear actin cap in health and disease. / Khatau, Shyam B.; Kim, Dong-Hwee; Hale, Christopher M.; Bloom, Ryan J.; Wirtz, Denis.

In: Nucleus, Vol. 1, No. 4, 01.01.2010, p. 337-342.

Research output: Contribution to journalArticle

Khatau, SB, Kim, D-H, Hale, CM, Bloom, RJ & Wirtz, D 2010, 'The perinuclear actin cap in health and disease', Nucleus, vol. 1, no. 4, pp. 337-342. https://doi.org/10.4161/nucl.1.4.12331
Khatau SB, Kim D-H, Hale CM, Bloom RJ, Wirtz D. The perinuclear actin cap in health and disease. Nucleus. 2010 Jan 1;1(4):337-342. https://doi.org/10.4161/nucl.1.4.12331
Khatau, Shyam B. ; Kim, Dong-Hwee ; Hale, Christopher M. ; Bloom, Ryan J. ; Wirtz, Denis. / The perinuclear actin cap in health and disease. In: Nucleus. 2010 ; Vol. 1, No. 4. pp. 337-342.
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