The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania

Effects of psychotropic drugs

Yong Ku Kim, I. B. Suh, H. Kim, Changsu Han, C. S. Lim, S. H. Choi, J. Licinio

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

Interleukin-12 (IL-12) plays a key role in promoting T helper 1 (Th1) responses and subsequent cell-mediated immunity. Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in 102 psychiatric patients (43 schizophrenia, 34 major depression and 25 bipolar disorder) and 85 normal controls. In addition, IL-12 levels of the patients were measured after an 8-week treatment to assess whether the levels were affected by medication. The IL-12 levels of the patient group with major depression were significantly higher than that of the control group, whereas no differences were found among the other groups. IL-12 values of the three patient groups decreased significantly after 8 weeks of treatment. These findings support the hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients.

Original languageEnglish
Pages (from-to)1107-1114
Number of pages8
JournalMolecular Psychiatry
Volume7
Issue number10
DOIs
Publication statusPublished - 2002 Dec 1

Fingerprint

Psychotropic Drugs
Interleukin-12
Bipolar Disorder
Schizophrenia
Psychiatry
Depression
Cellular Immunity
Antipsychotic Agents
Cytokines
Control Groups
Therapeutics

Keywords

  • Cytokine
  • Inflammatory response system
  • Interleukin-12
  • Major depression
  • Mania
  • Schizophrenia

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania : Effects of psychotropic drugs. / Kim, Yong Ku; Suh, I. B.; Kim, H.; Han, Changsu; Lim, C. S.; Choi, S. H.; Licinio, J.

In: Molecular Psychiatry, Vol. 7, No. 10, 01.12.2002, p. 1107-1114.

Research output: Contribution to journalArticle

Kim, Yong Ku ; Suh, I. B. ; Kim, H. ; Han, Changsu ; Lim, C. S. ; Choi, S. H. ; Licinio, J. / The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania : Effects of psychotropic drugs. In: Molecular Psychiatry. 2002 ; Vol. 7, No. 10. pp. 1107-1114.
@article{e7029f7d159949aea71c0af00379df56,
title = "The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: Effects of psychotropic drugs",
abstract = "Interleukin-12 (IL-12) plays a key role in promoting T helper 1 (Th1) responses and subsequent cell-mediated immunity. Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in 102 psychiatric patients (43 schizophrenia, 34 major depression and 25 bipolar disorder) and 85 normal controls. In addition, IL-12 levels of the patients were measured after an 8-week treatment to assess whether the levels were affected by medication. The IL-12 levels of the patient group with major depression were significantly higher than that of the control group, whereas no differences were found among the other groups. IL-12 values of the three patient groups decreased significantly after 8 weeks of treatment. These findings support the hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients.",
keywords = "Cytokine, Inflammatory response system, Interleukin-12, Major depression, Mania, Schizophrenia",
author = "Kim, {Yong Ku} and Suh, {I. B.} and H. Kim and Changsu Han and Lim, {C. S.} and Choi, {S. H.} and J. Licinio",
year = "2002",
month = "12",
day = "1",
doi = "10.1038/sj.mp.4001084",
language = "English",
volume = "7",
pages = "1107--1114",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania

T2 - Effects of psychotropic drugs

AU - Kim, Yong Ku

AU - Suh, I. B.

AU - Kim, H.

AU - Han, Changsu

AU - Lim, C. S.

AU - Choi, S. H.

AU - Licinio, J.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Interleukin-12 (IL-12) plays a key role in promoting T helper 1 (Th1) responses and subsequent cell-mediated immunity. Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in 102 psychiatric patients (43 schizophrenia, 34 major depression and 25 bipolar disorder) and 85 normal controls. In addition, IL-12 levels of the patients were measured after an 8-week treatment to assess whether the levels were affected by medication. The IL-12 levels of the patient group with major depression were significantly higher than that of the control group, whereas no differences were found among the other groups. IL-12 values of the three patient groups decreased significantly after 8 weeks of treatment. These findings support the hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients.

AB - Interleukin-12 (IL-12) plays a key role in promoting T helper 1 (Th1) responses and subsequent cell-mediated immunity. Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in 102 psychiatric patients (43 schizophrenia, 34 major depression and 25 bipolar disorder) and 85 normal controls. In addition, IL-12 levels of the patients were measured after an 8-week treatment to assess whether the levels were affected by medication. The IL-12 levels of the patient group with major depression were significantly higher than that of the control group, whereas no differences were found among the other groups. IL-12 values of the three patient groups decreased significantly after 8 weeks of treatment. These findings support the hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients.

KW - Cytokine

KW - Inflammatory response system

KW - Interleukin-12

KW - Major depression

KW - Mania

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=12244252752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12244252752&partnerID=8YFLogxK

U2 - 10.1038/sj.mp.4001084

DO - 10.1038/sj.mp.4001084

M3 - Article

VL - 7

SP - 1107

EP - 1114

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

IS - 10

ER -