The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: Effects of psychotropic drugs

Y. K. Kim, I. B. Suh, H. Kim, C. S. Han, C. S. Lim, S. H. Choi, J. Licinio

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    179 Citations (Scopus)

    Abstract

    Interleukin-12 (IL-12) plays a key role in promoting T helper 1 (Th1) responses and subsequent cell-mediated immunity. Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in 102 psychiatric patients (43 schizophrenia, 34 major depression and 25 bipolar disorder) and 85 normal controls. In addition, IL-12 levels of the patients were measured after an 8-week treatment to assess whether the levels were affected by medication. The IL-12 levels of the patient group with major depression were significantly higher than that of the control group, whereas no differences were found among the other groups. IL-12 values of the three patient groups decreased significantly after 8 weeks of treatment. These findings support the hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients.

    Original languageEnglish
    Pages (from-to)1107-1114
    Number of pages8
    JournalMolecular Psychiatry
    Volume7
    Issue number10
    DOIs
    Publication statusPublished - 2002

    Keywords

    • Cytokine
    • Inflammatory response system
    • Interleukin-12
    • Major depression
    • Mania
    • Schizophrenia

    ASJC Scopus subject areas

    • Molecular Biology
    • Psychiatry and Mental health
    • Cellular and Molecular Neuroscience

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