The polymorphisms k469e and g261r of intercellular adhesion molecule-1 and susceptibility to inflammatory bowel disease

A meta-Analysis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: The aim of this study was to explore whether polymorphisms of intercellular adhesion molecule-1 (ICAM-1) are associated with susceptibility to Crohn's disease (CD) and ulcerative colitis (UC). Methods: The authors conducted a meta-Analysis on the associations between the polymorphisms K469E and G241R of ICAM-1 and susceptibility to CD and UC. Results: A total of 8 studies with 801 patients with CD, 672 patients with UC, and 1,828 controls were included in the meta-Analysis. The meta-Analysis revealed no association between CD and the ICAM-1 469E allele among the subjects (OR=1.175, 95% CI=0.901-1.533, p=0.233). However, stratification by ethnicity indicated an association between the ICAM-1 469E allele and CD in Europeans (OR=1.425, 95% CI=1.013-2.002, p=0.042). Meta-Analysis using the homozygosity also showed an association with CD in Europeans (OR=2.054, 95% CI=1.036-4.073, p=0.039). The meta-Analysis revealed no association between UC and the ICAM-1 K469E polymorphism. No association between CD or UC and the ICAM-1 G241R polymorphism was observed. Conclusions: This meta-Analysis demonstrates that the ICAM-1 K469E polymorphism may be associated with susceptibility to CD in Europeans, but no association was found between ICAM-1 K469E and UC. In contrast, the G241R polymorphism was not found to be associated with susceptibility to either CD or UC.

Original languageEnglish
Pages (from-to)361-372
Number of pages12
JournalImmunological Investigations
Volume44
Issue number4
DOIs
Publication statusPublished - 2015 Jan 1

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Intercellular Adhesion Molecule-1
Inflammatory Bowel Diseases
Crohn Disease
Meta-Analysis
Ulcerative Colitis
Alleles

Keywords

  • Crohn's disease
  • ICAM-1
  • Meta-Analysis
  • Polymorphism
  • Ulcerative colitis

ASJC Scopus subject areas

  • Immunology

Cite this

@article{4990f9a500d34a04bda717ff3c6a1b24,
title = "The polymorphisms k469e and g261r of intercellular adhesion molecule-1 and susceptibility to inflammatory bowel disease: A meta-Analysis",
abstract = "Objective: The aim of this study was to explore whether polymorphisms of intercellular adhesion molecule-1 (ICAM-1) are associated with susceptibility to Crohn's disease (CD) and ulcerative colitis (UC). Methods: The authors conducted a meta-Analysis on the associations between the polymorphisms K469E and G241R of ICAM-1 and susceptibility to CD and UC. Results: A total of 8 studies with 801 patients with CD, 672 patients with UC, and 1,828 controls were included in the meta-Analysis. The meta-Analysis revealed no association between CD and the ICAM-1 469E allele among the subjects (OR=1.175, 95{\%} CI=0.901-1.533, p=0.233). However, stratification by ethnicity indicated an association between the ICAM-1 469E allele and CD in Europeans (OR=1.425, 95{\%} CI=1.013-2.002, p=0.042). Meta-Analysis using the homozygosity also showed an association with CD in Europeans (OR=2.054, 95{\%} CI=1.036-4.073, p=0.039). The meta-Analysis revealed no association between UC and the ICAM-1 K469E polymorphism. No association between CD or UC and the ICAM-1 G241R polymorphism was observed. Conclusions: This meta-Analysis demonstrates that the ICAM-1 K469E polymorphism may be associated with susceptibility to CD in Europeans, but no association was found between ICAM-1 K469E and UC. In contrast, the G241R polymorphism was not found to be associated with susceptibility to either CD or UC.",
keywords = "Crohn's disease, ICAM-1, Meta-Analysis, Polymorphism, Ulcerative colitis",
author = "Song, {Gwan Gyu} and Lee, {Young Ho}",
year = "2015",
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doi = "10.3109/08820139.2015.1010685",
language = "English",
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pages = "361--372",
journal = "Immunological Investigations",
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T1 - The polymorphisms k469e and g261r of intercellular adhesion molecule-1 and susceptibility to inflammatory bowel disease

T2 - A meta-Analysis

AU - Song, Gwan Gyu

AU - Lee, Young Ho

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objective: The aim of this study was to explore whether polymorphisms of intercellular adhesion molecule-1 (ICAM-1) are associated with susceptibility to Crohn's disease (CD) and ulcerative colitis (UC). Methods: The authors conducted a meta-Analysis on the associations between the polymorphisms K469E and G241R of ICAM-1 and susceptibility to CD and UC. Results: A total of 8 studies with 801 patients with CD, 672 patients with UC, and 1,828 controls were included in the meta-Analysis. The meta-Analysis revealed no association between CD and the ICAM-1 469E allele among the subjects (OR=1.175, 95% CI=0.901-1.533, p=0.233). However, stratification by ethnicity indicated an association between the ICAM-1 469E allele and CD in Europeans (OR=1.425, 95% CI=1.013-2.002, p=0.042). Meta-Analysis using the homozygosity also showed an association with CD in Europeans (OR=2.054, 95% CI=1.036-4.073, p=0.039). The meta-Analysis revealed no association between UC and the ICAM-1 K469E polymorphism. No association between CD or UC and the ICAM-1 G241R polymorphism was observed. Conclusions: This meta-Analysis demonstrates that the ICAM-1 K469E polymorphism may be associated with susceptibility to CD in Europeans, but no association was found between ICAM-1 K469E and UC. In contrast, the G241R polymorphism was not found to be associated with susceptibility to either CD or UC.

AB - Objective: The aim of this study was to explore whether polymorphisms of intercellular adhesion molecule-1 (ICAM-1) are associated with susceptibility to Crohn's disease (CD) and ulcerative colitis (UC). Methods: The authors conducted a meta-Analysis on the associations between the polymorphisms K469E and G241R of ICAM-1 and susceptibility to CD and UC. Results: A total of 8 studies with 801 patients with CD, 672 patients with UC, and 1,828 controls were included in the meta-Analysis. The meta-Analysis revealed no association between CD and the ICAM-1 469E allele among the subjects (OR=1.175, 95% CI=0.901-1.533, p=0.233). However, stratification by ethnicity indicated an association between the ICAM-1 469E allele and CD in Europeans (OR=1.425, 95% CI=1.013-2.002, p=0.042). Meta-Analysis using the homozygosity also showed an association with CD in Europeans (OR=2.054, 95% CI=1.036-4.073, p=0.039). The meta-Analysis revealed no association between UC and the ICAM-1 K469E polymorphism. No association between CD or UC and the ICAM-1 G241R polymorphism was observed. Conclusions: This meta-Analysis demonstrates that the ICAM-1 K469E polymorphism may be associated with susceptibility to CD in Europeans, but no association was found between ICAM-1 K469E and UC. In contrast, the G241R polymorphism was not found to be associated with susceptibility to either CD or UC.

KW - Crohn's disease

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KW - Meta-Analysis

KW - Polymorphism

KW - Ulcerative colitis

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