The potential for skin irritation, phototoxicity, and sensitization of ZnO nanoparticles

Yeon Sue Jang, Eun Young Lee, Yoon Hee Park, Sang Hoon Jeong, Sang Geun Lee, Yu Ri Kim, Meyoung-Kon Kim, Sang Wook Son

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

In spite of widely use of zinc oxide (ZnO) nanoparticles (NPs) in cosmetic industry and in our daily lives, insufficient studies have evaluated the potential of their toxic response. This study was conducted to investigate the potential of cytotoxicity induced by ZnO NPs, especially influences of the surface charge and different particle size. Assessment of potential of skin irritation was estimated using human skin equivalent model (HSEM), and an animal model. And the evaluation of skin phototoxicity was tested by the 3T3 neutral red uptake test. Lastly, the potential of skin sensitization was evaluated by a local lymph node assay (LLNA). The results from this study demonstrated that ZnO NPs are not dermal sensitizers and do not induce skin irritation. But they may produce phototoxicity.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalMolecular and Cellular Toxicology
Volume8
Issue number2
DOIs
Publication statusPublished - 2012 Jun 1

Fingerprint

Phototoxic Dermatitis
Zinc Oxide
Nanoparticles
Skin
Neutral Red
Local Lymph Node Assay
Cosmetics
Poisons
Cytotoxicity
Surface charge
Assays
Particle Size
Animals
Particle size
Industry
Animal Models

Keywords

  • Cytotoxicity
  • Phototoxicity
  • Skin irritation
  • Skin sensitization
  • ZnO

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Pathology and Forensic Medicine

Cite this

The potential for skin irritation, phototoxicity, and sensitization of ZnO nanoparticles. / Jang, Yeon Sue; Lee, Eun Young; Park, Yoon Hee; Jeong, Sang Hoon; Lee, Sang Geun; Kim, Yu Ri; Kim, Meyoung-Kon; Son, Sang Wook.

In: Molecular and Cellular Toxicology, Vol. 8, No. 2, 01.06.2012, p. 171-177.

Research output: Contribution to journalArticle

Jang, Yeon Sue ; Lee, Eun Young ; Park, Yoon Hee ; Jeong, Sang Hoon ; Lee, Sang Geun ; Kim, Yu Ri ; Kim, Meyoung-Kon ; Son, Sang Wook. / The potential for skin irritation, phototoxicity, and sensitization of ZnO nanoparticles. In: Molecular and Cellular Toxicology. 2012 ; Vol. 8, No. 2. pp. 171-177.
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