The potential role of exosomes derived from ovarian cancer cells for diagnostic and therapeutic approaches

Changwon Yang, Hee Seung Kim, Gwonhwa Song, Whasun Lim

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Most patients with ovarian cancer (OC) are diagnosed at the advanced stages due to the absence of appropriate early diagnostic markers. Thus, OC is a gynecological disease with a low-survival rate. Exosomes are extracellular vesicles that are widely being considered as mediators for the noninvasive diagnosis of OC. Exosomes are expected to aid in the effective diagnosis of OC because they carry components, such as RNAs, proteins, and lipids, the compositions of which vary depending on the pathological characteristics of the patient. In this review, we document the methods that have been developed to detect exosomes and their components in OC. We also assess the potential biomarkers contained in exosomes that could be clinically useful, such as proteins, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and phospholipids. Moreover, we described the role played by exosomes in the tumor microenvironment and in OC angiogenesis, migration, and tumor growth. Various types of cells in the tumor microenvironment, including macrophages, fibroblasts, and mesenchymal stem cells (MSCs), interact directly with exosomes and promote or inhibit the progression of OC. Therefore, we summarize the studies that have suggested a therapeutic approach to OC using exosomes. Collectively, understanding the mechanism of exosome-based OC progression would broaden our knowledge regarding the diagnosis and therapy of OC.

Original languageEnglish
Pages (from-to)21493-21503
Number of pages11
JournalJournal of Cellular Physiology
Volume234
Issue number12
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Exosomes
Ovarian Neoplasms
Tumors
Cells
Long Noncoding RNA
Macrophages
Biomarkers
Fibroblasts
Stem cells
MicroRNAs
Phospholipids
Proteins
Therapeutics
Tumor Microenvironment
RNA
Lipids
Chemical analysis
Mesenchymal Stromal Cells
Survival Rate

Keywords

  • biomarker
  • exosome
  • microenvironment
  • microRNA
  • ovarian cancer cells

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

The potential role of exosomes derived from ovarian cancer cells for diagnostic and therapeutic approaches. / Yang, Changwon; Kim, Hee Seung; Song, Gwonhwa; Lim, Whasun.

In: Journal of Cellular Physiology, Vol. 234, No. 12, 01.01.2019, p. 21493-21503.

Research output: Contribution to journalReview article

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