The potential utility of aripiprazole augmentation for major depressive disorder with mixed features specifier: A retrospective study

Changsu Han, Sheng Min Wang, Won Myong Bahk, Soo Jung Lee, Ashwin A. Patkar, Prakash S. Masand, Chi Un Pae

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: The present study aimed to observe potential benefit of aripiprazole augmentation in the treatment of major depressive disorder with mixed specifier (MDDM) in naturalistic treatment setting. Methods: Data were collected from MDDM patients using a retrospective chart review for 8 weeks (week-8 and week 0) in routine practice. All patients were on current antidepressants upon starting of aripiprazole. Patients were treated without restriction of doses of aripiprazole. The primary endpoint was the mean change of Montgomery-Åsberg Depression Rating Scale (MADRS) total scores along with various secondary endpoint measures. Results: In total 38 patients were analyzed. The changes of MADRS, Clinical Global Impression (CGI)-severity, Young Mania Rating Scale, Sheehan Disability Scale, and CGI-clinical benefit total scores from baseline to the endpoint were-7.1,-0.8,-4.9,-4.1, and-3.6, respectively (all p < 0.0001). At the endpoint, the responder and remitter rates by MADRS score criteria were approximately 32% and 21%, respectively. Conclusion: The present findings have clearly shown the effectiveness and tolerability of aripiprazole augmentation for MDDM patients in routine practice. The present study warrants subsequent, adequately-powered, well-controlled studies for generalizability near future.

Original languageEnglish
Pages (from-to)495-502
Number of pages8
JournalClinical Psychopharmacology and Neuroscience
Volume17
Issue number4
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Aripiprazole
  • Depressive disorder
  • Effectiveness
  • Mixed specifier
  • Tolerability

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Pharmacology (medical)

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