TY - JOUR
T1 - The predictive accuracy of sentinel nodes mapping in the setting of pulmonary metastasectomy
AU - Kim, Hyun Koo
AU - Lee, Kwanghyoung
AU - Han, Kook Nam
AU - Eo, Jae Seon
AU - Kim, Sungeun
AU - Choi, Young Ho
N1 - Funding Information:
This work was supported by a Grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (No. A121074) and a National Research Foundation of Korea (NRF) Grant funded by the Ministry of Education, Science and Technology (No. NRF-2015R1A2A2A04005760).
Publisher Copyright:
© 2017, The Author(s).
PY - 2017/2/1
Y1 - 2017/2/1
N2 - This is the first study to evaluate the feasibility of mediastinal lymph node dissection (MLND) based on sentinel lymph node (SLN) status during pulmonary metastasectomy. A total of 22 patients (16 men, 6 women; age 63.3 ± 7.01 years) who were candidates for metastasectomy through segmentectomy or lobectomy with MLND owing to cancers metastatic to the lung were enrolled in this study. Radiotracer was administered at the peritumoral region before surgery or soon after initiating surgery. During the operation, the radioactivity of the lymph nodes (ex vivo) was counted with a handheld gamma probe after MLND. Lobectomy was performed in 17 patients, and segmentectomy, in 5 patients. The number of dissected lymph nodes per patient was 14.4 ± 8.69 (range, 5–36). In all patients, the SLN could be detected, and the number of SLNs identified was 2.0 ± 1.15 (range, 1–5) per patient. Lymph node metastasis was identified in 3 of the 22 patients (13.6%), and none of the 3 patients with N1 or N2 disease had false-negative SLNs. SLN identification might be an indicator of whether or not MLND should be performed during pulmonary metastasectomy. However, further large-volume and multi-institutional studies are needed.
AB - This is the first study to evaluate the feasibility of mediastinal lymph node dissection (MLND) based on sentinel lymph node (SLN) status during pulmonary metastasectomy. A total of 22 patients (16 men, 6 women; age 63.3 ± 7.01 years) who were candidates for metastasectomy through segmentectomy or lobectomy with MLND owing to cancers metastatic to the lung were enrolled in this study. Radiotracer was administered at the peritumoral region before surgery or soon after initiating surgery. During the operation, the radioactivity of the lymph nodes (ex vivo) was counted with a handheld gamma probe after MLND. Lobectomy was performed in 17 patients, and segmentectomy, in 5 patients. The number of dissected lymph nodes per patient was 14.4 ± 8.69 (range, 5–36). In all patients, the SLN could be detected, and the number of SLNs identified was 2.0 ± 1.15 (range, 1–5) per patient. Lymph node metastasis was identified in 3 of the 22 patients (13.6%), and none of the 3 patients with N1 or N2 disease had false-negative SLNs. SLN identification might be an indicator of whether or not MLND should be performed during pulmonary metastasectomy. However, further large-volume and multi-institutional studies are needed.
KW - Cancers metastatic to the lung
KW - Mediastinal lymph node dissection
KW - Metastasectomy
UR - http://www.scopus.com/inward/record.url?scp=85008462021&partnerID=8YFLogxK
U2 - 10.1007/s10585-016-9834-6
DO - 10.1007/s10585-016-9834-6
M3 - Article
C2 - 28062976
AN - SCOPUS:85008462021
VL - 34
SP - 125
EP - 131
JO - Clinical and Experimental Metastasis
JF - Clinical and Experimental Metastasis
SN - 0262-0898
IS - 2
ER -
