The preoperative positivity for serum hepatitis B e antigen did not affect overall survival after curative resection of hepatitis B virus-related hepatocellular carcinoma

Gi Hong Choi, Dong Hyun Kim, Sae-Byeol Choi, Chang Moo Kang, Kyung Sik Kim, Jin Sub Choi, Woo Jung Lee, Kwang Hyub Han, Chae Yoon Chon, Byong Ro Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background and Aim: Previous studies have reported different risk factors for early and late intrahepatic recurrence after resection of hepatocellular carcinoma (HCC). However, the prognostic significance of the risk factors for early and late recurrence has not been clarified. Methods: A total of 190 Hepatitis B surface antigen-positive patients who received curative resection for HCC were reviewed. We investigated prognostic factors for disease-free and overall survival after resection, and further analyzed the relationship between significant prognostic factors and risk factors for early (≤14 months) and late (>14 months) intrahepatic recurrence. Results: The 5-year disease-free and overall survival rates were 43.9% and 71.5%, respectively. In multivariate analysis, adverse prognostic factors for disease-free survival were presence of serum HBeAg, perioperative transfusion, and the presence of portal vein invasion (PVI) and/or intrahepatic metastasis (IM). Multivariate analysis revealed that overall survival was associated with ICG R15, serum albumin, Edmondson-Steiner grade, and the presence of PVI and/or IM. Independent risk factors for early intrahepatic recurrence were perioperative transfusion and PVI and/or IM, whereas positivity for HBeAg was the only risk factor for late recurrence. In addition, post-recurrence survival in patients with late intrahepatic recurrence was completely comparable to that of patients who never experienced recurrence. Conclusions: The presence of serum HBeAg, the risk factor for late intrahepatic recurrence did not affect overall survival after resection because late recurrence was relatively well controlled by current available treatments. To further improve long-term surgical outcomes, effective treatment and preventive methods for early intrahepatic recurrence should be investigated.

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume24
Issue number3
DOIs
Publication statusPublished - 2009 Jan 1
Externally publishedYes

Fingerprint

Hepatitis B e Antigens
Hepatitis B virus
Hepatocellular Carcinoma
Recurrence
Survival
Serum
Portal Vein
Disease-Free Survival
Neoplasm Metastasis
Multivariate Analysis
Hepatitis B Surface Antigens
Serum Albumin
Survival Rate

Keywords

  • Curative resection
  • Hepatocellular carcinoma
  • Prognostic factors
  • Risk factors for intrahepatic recurrence

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

The preoperative positivity for serum hepatitis B e antigen did not affect overall survival after curative resection of hepatitis B virus-related hepatocellular carcinoma. / Choi, Gi Hong; Kim, Dong Hyun; Choi, Sae-Byeol; Kang, Chang Moo; Kim, Kyung Sik; Choi, Jin Sub; Lee, Woo Jung; Han, Kwang Hyub; Chon, Chae Yoon; Kim, Byong Ro.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 24, No. 3, 01.01.2009, p. 391-398.

Research output: Contribution to journalArticle

Choi, Gi Hong ; Kim, Dong Hyun ; Choi, Sae-Byeol ; Kang, Chang Moo ; Kim, Kyung Sik ; Choi, Jin Sub ; Lee, Woo Jung ; Han, Kwang Hyub ; Chon, Chae Yoon ; Kim, Byong Ro. / The preoperative positivity for serum hepatitis B e antigen did not affect overall survival after curative resection of hepatitis B virus-related hepatocellular carcinoma. In: Journal of Gastroenterology and Hepatology (Australia). 2009 ; Vol. 24, No. 3. pp. 391-398.
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T1 - The preoperative positivity for serum hepatitis B e antigen did not affect overall survival after curative resection of hepatitis B virus-related hepatocellular carcinoma

AU - Choi, Gi Hong

AU - Kim, Dong Hyun

AU - Choi, Sae-Byeol

AU - Kang, Chang Moo

AU - Kim, Kyung Sik

AU - Choi, Jin Sub

AU - Lee, Woo Jung

AU - Han, Kwang Hyub

AU - Chon, Chae Yoon

AU - Kim, Byong Ro

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Background and Aim: Previous studies have reported different risk factors for early and late intrahepatic recurrence after resection of hepatocellular carcinoma (HCC). However, the prognostic significance of the risk factors for early and late recurrence has not been clarified. Methods: A total of 190 Hepatitis B surface antigen-positive patients who received curative resection for HCC were reviewed. We investigated prognostic factors for disease-free and overall survival after resection, and further analyzed the relationship between significant prognostic factors and risk factors for early (≤14 months) and late (>14 months) intrahepatic recurrence. Results: The 5-year disease-free and overall survival rates were 43.9% and 71.5%, respectively. In multivariate analysis, adverse prognostic factors for disease-free survival were presence of serum HBeAg, perioperative transfusion, and the presence of portal vein invasion (PVI) and/or intrahepatic metastasis (IM). Multivariate analysis revealed that overall survival was associated with ICG R15, serum albumin, Edmondson-Steiner grade, and the presence of PVI and/or IM. Independent risk factors for early intrahepatic recurrence were perioperative transfusion and PVI and/or IM, whereas positivity for HBeAg was the only risk factor for late recurrence. In addition, post-recurrence survival in patients with late intrahepatic recurrence was completely comparable to that of patients who never experienced recurrence. Conclusions: The presence of serum HBeAg, the risk factor for late intrahepatic recurrence did not affect overall survival after resection because late recurrence was relatively well controlled by current available treatments. To further improve long-term surgical outcomes, effective treatment and preventive methods for early intrahepatic recurrence should be investigated.

AB - Background and Aim: Previous studies have reported different risk factors for early and late intrahepatic recurrence after resection of hepatocellular carcinoma (HCC). However, the prognostic significance of the risk factors for early and late recurrence has not been clarified. Methods: A total of 190 Hepatitis B surface antigen-positive patients who received curative resection for HCC were reviewed. We investigated prognostic factors for disease-free and overall survival after resection, and further analyzed the relationship between significant prognostic factors and risk factors for early (≤14 months) and late (>14 months) intrahepatic recurrence. Results: The 5-year disease-free and overall survival rates were 43.9% and 71.5%, respectively. In multivariate analysis, adverse prognostic factors for disease-free survival were presence of serum HBeAg, perioperative transfusion, and the presence of portal vein invasion (PVI) and/or intrahepatic metastasis (IM). Multivariate analysis revealed that overall survival was associated with ICG R15, serum albumin, Edmondson-Steiner grade, and the presence of PVI and/or IM. Independent risk factors for early intrahepatic recurrence were perioperative transfusion and PVI and/or IM, whereas positivity for HBeAg was the only risk factor for late recurrence. In addition, post-recurrence survival in patients with late intrahepatic recurrence was completely comparable to that of patients who never experienced recurrence. Conclusions: The presence of serum HBeAg, the risk factor for late intrahepatic recurrence did not affect overall survival after resection because late recurrence was relatively well controlled by current available treatments. To further improve long-term surgical outcomes, effective treatment and preventive methods for early intrahepatic recurrence should be investigated.

KW - Curative resection

KW - Hepatocellular carcinoma

KW - Prognostic factors

KW - Risk factors for intrahepatic recurrence

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