The prevalence of and risk factors for barrett's esophagus in a Korean population: A nationwide multicenter prospective study

Jong Jae Park, Jae Woo Kim, Hyun Jin Kim, Moon Gi Chung, Seon Mee Park, Gwang Ho Baik, Byung Kyu Nah, Su Youn Nam, Kang Seok Seo, Byung Sung Ko, Jae Young Jang, Byeong Gwan Kim, Ji Won Kim, Youn Seon Choi, Moon Kyung Joo, Jin Il Kim, Mee Yon Cho, Nayoung Kim, Soo Heon Park, Hyun Chae JungIn Sik Chung

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Abstract

Objective: The aim of this study was to evaluate the prevalence of Barrett's esophagus (BE) in the general Korean population by evaluating screening esophagogastroduodenoscopy. In addition, the risk factors for BE were identified. Method: An esophagogastroduodenoscopy examination was performed in 25,536 subjects who had upper endoscopy screening from January 2006 to July 2006. Results: Two hundred and fifteen subjects were confirmed to have BE by pathology, thus the prevalence of BE was calculated to be 0.84%. The endoscopic findings were subdivided into 2 groups: BE without reflux esophagitis (RE), which included 167 (77.7%), and BE with RE, which included 48 (22.3%). The analysis of symptoms showed that only 60.1% of the subjects with BE had reflux symptoms. Chest pain [odds ratio (OR): 1.48, 95% confidence interval (CI): 1.04-2.11] and epigastric soreness (OR: 1.42, 95% CI: 1.05-1.93) were found more frequently in the subjects with BE compared with the normal subjects. The multivariate analysis showed that the risk factors for all subjects with BE were a male sex (OR: 1.82, 95% CI: 1.32-2.50), nonsteroidal anti-inflammatory drug use (OR: 2.02, 95% CI: 1.28-3.20), hiatal hernia (OR: 5.66, 95% CI: 3.70-8.66), and an age ≥60 compared with an age <40 (OR: 1.81, 95% CI: 1.07-3.09). There was no significant difference associated with RE. Conclusions: The prevalence of BE in Korean patients presenting for a routine health check-up was 0.84%, lower than reported in Western countries. Among the subjects with BE 77.7% did not have endoscopic erosions and there were no reflux symptoms in 39.9%. These results suggest that regular endoscopic screening with a high index of suspicion is necessary for the diagnosis of BE.

Original languageEnglish
Pages (from-to)907-914
Number of pages8
JournalJournal of Clinical Gastroenterology
Volume43
Issue number10
DOIs
Publication statusPublished - 2009 Nov

Keywords

  • Barrett esophagus, prevalence, reflux symptom, risk factors

ASJC Scopus subject areas

  • Gastroenterology

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    Park, J. J., Kim, J. W., Kim, H. J., Chung, M. G., Park, S. M., Baik, G. H., Nah, B. K., Nam, S. Y., Seo, K. S., Ko, B. S., Jang, J. Y., Kim, B. G., Kim, J. W., Choi, Y. S., Joo, M. K., Kim, J. I., Cho, M. Y., Kim, N., Park, S. H., ... Chung, I. S. (2009). The prevalence of and risk factors for barrett's esophagus in a Korean population: A nationwide multicenter prospective study. Journal of Clinical Gastroenterology, 43(10), 907-914. https://doi.org/10.1097/MCG.0b013e318196bd11