The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: A nationwide multicentre prospective study in Korea

N. Kim, S. W. Lee, S. I. Cho, C. G. Park, C. H. Yang, H. S. Kim, J. S. Rew, J. S. Moon, S. Kim, S. H. Park, H. C. Jung, I. S. Chung

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Abstract

Background: Prospective nationwide multicentre studies that have evaluated endoscopic findings and reflux symptoms using a well-designed questionnaire are very rare. Aim: To compare the prevalence rates of and risk factors for erosive oesophagitis and non-erosive reflux disease (NERD) in the Korean population. Methods: A gastroscopic examination was performed on 25 536 subjects who visited 40 Healthcare Centers for a health check-up. A gastro-oesophageal reflux questionnaire and multivariate analysis were used to determine the risk factors for erosive oesophagitis and NERD. Results: 2019 (8%) and 996 subjects (4%) had erosive oesophagitis and non-erosive reflux disease, respectively; only 58% of subjects with erosive oesophagitis had reflux symptoms. Multivariate analysis showed that the risk factors for erosive oesophagitis and NERD differed, i.e. those of erosive oesophagitis were male, a Helicobacter pylori eradication history, alcohol, body mass index ≥25 and hiatal hernia. In contrast, the risk factors for NERD were female, age <40 and ≥60 vs. 40-59 years, body mass index <23 and a monthly income <$1000, glucose ≥126 mg/dL, smoking, a stooping posture at work and antibiotic usage. Conclusions: The prevalence rates of erosive oesophagitis and NERD were 8% and 4%, respectively, in Korean health check-up subjects. The risk factors for erosive oesophagitis and NERD were found to differ, which indicates that their underlying pathogeneses are distinct.

Original languageEnglish
Pages (from-to)173-185
Number of pages13
JournalAlimentary Pharmacology and Therapeutics
Volume27
Issue number2
DOIs
Publication statusPublished - 2008 Jan

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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    Kim, N., Lee, S. W., Cho, S. I., Park, C. G., Yang, C. H., Kim, H. S., Rew, J. S., Moon, J. S., Kim, S., Park, S. H., Jung, H. C., & Chung, I. S. (2008). The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: A nationwide multicentre prospective study in Korea. Alimentary Pharmacology and Therapeutics, 27(2), 173-185. https://doi.org/10.1111/j.1365-2036.2007.03561.x