The prevalence of metabolic syndrome in patients with gout: A multicenter study

Hee Rho Young, Jae Choi Seong, Young Ho Lee, Jong Dae Ji, Kyung Mook Choi, Sei-Hyun Baik, Seung Hie Chung, Chae Gi Kim, Jung Yoon Choe, Won Lee Sung, Tae Chung Won, Gwan Gyu Song

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Abstract

It has been suggested that hyperuricemia and possibly gout are associated with the metabolic syndrome, but there have been no direct studies. This study was undertaken to obtain the prevalence of the metabolic syndrome in patients with gout and to compare it with those from the general population studies. This was a 4-institutional case-historical control study composed of 168 patients with gout. We assessed the prevalence of metabolic syndrome according to the ATP III criteria and compared the prevalence with that of the historical controls. To elucidate the factors in gout that were associated with metabolic syndrome, a multivariate analysis was done. The age-adjusted prevalence of metabolic syndrome in gout patients was 43.6%, which was significantly higher than that of the Korean control population (5.2%) from the previous studies. Patients with gout had more components of metabolic syndrome than did the controls. Body mass index (BMI, OR=1.357 (95%CI 1.111-1.657)) and high density lipoprotein (HDL, OR=0.774 (95%CI 0.705-0.850)) were the variables most significantly associated with the occurrence of metabolic syndrome in gout, but alcohol consumption did not show such associations. Gout is associated with the metabolic syndrome, and furthermore, obesity and dyslipidemia were the factors most associated with the syndrome in these patients.

Original languageEnglish
Pages (from-to)1029-1033
Number of pages5
JournalJournal of Korean Medical Science
Volume20
Issue number6
Publication statusPublished - 2005 Dec 1

Keywords

  • Gout
  • Hyperuricemia
  • Metabolic Syndrome X

ASJC Scopus subject areas

  • Medicine(all)

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    Young, H. R., Seong, J. C., Lee, Y. H., Ji, J. D., Choi, K. M., Baik, S-H., Chung, S. H., Kim, C. G., Choe, J. Y., Sung, W. L., Won, T. C., & Song, G. G. (2005). The prevalence of metabolic syndrome in patients with gout: A multicenter study. Journal of Korean Medical Science, 20(6), 1029-1033.