TY - JOUR
T1 - The preventive effects of lifestyle intervention on the occurrence of diabetes mellitus and acute myocardial infarction in metabolic syndrome
AU - Kim, D.
AU - Yoon, Seok-Jun
AU - Lim, D. S.
AU - Gong, Y. H.
AU - Ko, S.
AU - Lee, Y. H.
AU - Lee, H. S.
AU - Park, M. S.
AU - Kim, K. H.
AU - Kim, Y. A.
N1 - Funding Information:
This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Korea (grant no. 1320310 ).
Publisher Copyright:
© 2016
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Objectives Metabolic syndrome (MS), as a precursor of diabetes mellitus (DM) and cardiovascular disease, is increasing steadily worldwide. We examined the preventive effects of lifestyle intervention on the occurrence of DM and acute myocardial infarction (AMI) in MS. Study design Observational study on disease occurrence after lifestyle intervention. Methods The lifestyle intervention was administered to subjects with MS participating in a metropolitan lifestyle intervention program for 1 year. The same numbers of non-participating age- and sex-matched subjects with MS were randomly extracted from national health examination data. After intervention or examination, new occurrences of hypertension, DM, and AMI were identified through the national health insurance claims data during 1 year. For DM and AMI, multivariate logistic regression analysis for the factors affecting each disease was performed. Results In the intervention group and the control group (14,918 in each group), the occurrence of hypertension was 555 (6.07%) and 751 (8.33%), the occurrence of DM was 324 (2.55%) and 488 (3.89%), the occurrence of dyslipidemia was 321 (2.59%) and 373 (2.72%), and the occurrence of AMI was 13 (0.09%) and 26 (0.17%), respectively. In multivariate logistic regression analysis, adjusted odds ratios for intervention were 0.752 (95% confidence interval [CI]: 0.644–0.879) and 0.499 (95% CI: 0.251–0.992) for DM and AMI, respectively, indicating that lifestyle intervention has a preventive effect. Conclusions Lifestyle intervention in MS has preventive effects on the occurrence of DM and AMI, and long-term follow-up is needed to evaluate these preventive effects in more detail.
AB - Objectives Metabolic syndrome (MS), as a precursor of diabetes mellitus (DM) and cardiovascular disease, is increasing steadily worldwide. We examined the preventive effects of lifestyle intervention on the occurrence of DM and acute myocardial infarction (AMI) in MS. Study design Observational study on disease occurrence after lifestyle intervention. Methods The lifestyle intervention was administered to subjects with MS participating in a metropolitan lifestyle intervention program for 1 year. The same numbers of non-participating age- and sex-matched subjects with MS were randomly extracted from national health examination data. After intervention or examination, new occurrences of hypertension, DM, and AMI were identified through the national health insurance claims data during 1 year. For DM and AMI, multivariate logistic regression analysis for the factors affecting each disease was performed. Results In the intervention group and the control group (14,918 in each group), the occurrence of hypertension was 555 (6.07%) and 751 (8.33%), the occurrence of DM was 324 (2.55%) and 488 (3.89%), the occurrence of dyslipidemia was 321 (2.59%) and 373 (2.72%), and the occurrence of AMI was 13 (0.09%) and 26 (0.17%), respectively. In multivariate logistic regression analysis, adjusted odds ratios for intervention were 0.752 (95% confidence interval [CI]: 0.644–0.879) and 0.499 (95% CI: 0.251–0.992) for DM and AMI, respectively, indicating that lifestyle intervention has a preventive effect. Conclusions Lifestyle intervention in MS has preventive effects on the occurrence of DM and AMI, and long-term follow-up is needed to evaluate these preventive effects in more detail.
KW - Acute myocardial infarction
KW - Diabetes mellitus
KW - Lifestyle intervention
KW - Metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=84991071122&partnerID=8YFLogxK
U2 - 10.1016/j.puhe.2016.06.012
DO - 10.1016/j.puhe.2016.06.012
M3 - Article
C2 - 27406975
AN - SCOPUS:84991071122
VL - 139
SP - 178
EP - 182
JO - Public Health
JF - Public Health
SN - 0033-3506
ER -
