@article{653ffeaa121f4213accf8668c18e3549,
title = "The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression",
abstract = "A major mechanism contributing to synaptic plasticity involves alterations in the number of AMPA receptors (AMPARs) expressed at synapses. Hippocampal CA1 synapses, where this process has been most extensively studied, are highly heterogeneous with respect to their probability of neurotransmitter release, P(r). It is unknown whether there is any relationship between the extent of plasticity-related AMPAR trafficking and the initial P(r) of a synapse. To address this question, we induced metabotropic glutamate receptor (mGluR) dependent long-term depression (mGluR-LTD) and assessed AMPAR trafficking and P(r) at individual synapses, using SEP-GluA2 and FM4-64, respectively. We found that either pharmacological or synaptic activation of mGluR1 reduced synaptic SEP-GluA2 in a manner that depends upon P(r); this process involved an activity-dependent reduction in surface mGluR1 that selectively protects high-P(r) synapses from synaptic weakening. Consequently, the extent of postsynaptic plasticity can be pre-tuned by presynaptic activity.",
keywords = "AMPA, DHPG, FM dye, LTD, Long-term depression, P(r), mGluR, metabotropic, probability of release, theta burst",
author = "Sanderson, {Thomas M.} and Bradley, {Clarrisa A.} and John Georgiou and Hong, {Yun Hwa} and Ng, {Ai Na} and Yeseul Lee and Kim, {Hee Dae} and Doyeon Kim and Mascia Amici and Son, {Gi Hoon} and Min Zhuo and Kyungjin Kim and Kaang, {Bong Kiun} and Kim, {Sang Jeong} and Collingridge, {Graham L.}",
note = "Funding Information: This study was supported by the World-Class University (WCU) program through the National Research Foundation of Korea (R32-10142), a National Research Foundation of Korea (NRF) grant funded by the Korean government (Ministry of Science, ICT and Future Planning [MSIP]) (2018R1A5A2025964), U.K. Medical Research Council (MRC) grant MR/K023098/1, Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/K019899/1, European Union (EU) grant 341089-HippoKAR, and Canadian Institutes of Health Research (CIHR) Foundation grant 154276. This work was also supported by the Brain Canada Foundation through the Canada Brain Research Fund, with the financial support of Health Canada. Funding Information: This study was supported by the World-Class University (WCU) program through the National Research Foundation of Korea ( R32-10142 ), a National Research Foundation of Korea (NRF) grant funded by the Korean government ( Ministry of Science, ICT and Future Planning [MSIP]) ( 2018R1A5A2025964 ), U.K. Medical Research Council (MRC) grant MR/K023098/1 , Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/K019899/1 , European Union (EU) grant 341089-HippoKAR , and Canadian Institutes of Health Research (CIHR) Foundation grant 154276 . This work was also supported by the Brain Canada Foundation through the Canada Brain Research Fund , with the financial support of Health Canada . Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
month = dec,
day = "26",
doi = "10.1016/j.celrep.2018.12.010",
language = "English",
volume = "25",
pages = "3631--3646.e3",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "13",
}