The prognostic significance of E-cadherin and liver intestine-cadherin expression in colorectal cancer

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Abstract

PURPOSE: The significance of liver intestine-cadherin as a potential marker has been growing in the field of oncology, because of its unique features compared with classic cadherins. We investigated the coexpression patterns of E-cadherin and liver intestine-cadherin in colorectal cancer, and determined whether differences in expression patterns were associated with clinicopathologic parameters and also which relationship between these two adhesion molecules existed in colorectal cancer. METHODS: Expression pattern of E-cadherin and liver intestine-cadherin was investigated immunohistochemically in 207 colorectal cancers along with clinicopathologic parameters. RESULTS: Reduced expression of liver intestine-cadherin was detected in 51 percent (n=105) of tumors. Such expression was found to be associated with tumoral dedifferentiation (P=0.015) and in a multivariate analysis was associated with a significant worse overall survival after adjustment for tumor stage, differentiation, and E-cadherin status (hazard ratio, 1.951; 95 percent confidence interval, 1.06-3.592; P=0.032). Fifteen percent (n=32) of tumors showed reduced expression of E-cadherin and had relationship with tumoral dedifferentiation (P<0.001), lymph node metastasis (P=0.004), and advanced stage (P=0.029). Reduced expression of E-cadherin was associated with short overall survival (P=0.028); however, in a multivariate analysis, it was not statistically significant. CONCLUSIONS: Reduced expression of liver intestine-cadherin had a significant correlation with tumoral dedifferentiation and short overall survival in this series. In addition, early and frequent loss of liver intestine-cadherin expression might be a more sensitive indicator than E-cadherin to predict more aggressive tumoral behavior.

Original languageEnglish
Pages (from-to)1873-1880
Number of pages8
JournalDiseases of the Colon and Rectum
Volume50
Issue number11
DOIs
Publication statusPublished - 2007 Nov 1

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Cadherins
Intestines
Colorectal Neoplasms
Liver
Multivariate Analysis
Neoplasms
Lymph Nodes
Confidence Intervals
Neoplasm Metastasis

Keywords

  • Colorectal cancer
  • E-cadherin
  • Immunohistochemistry
  • Liver intestine-cadherin
  • Overall survival
  • Potential marker

ASJC Scopus subject areas

  • Gastroenterology

Cite this

@article{3bfbbbca1ba7479f8679246ad9205a91,
title = "The prognostic significance of E-cadherin and liver intestine-cadherin expression in colorectal cancer",
abstract = "PURPOSE: The significance of liver intestine-cadherin as a potential marker has been growing in the field of oncology, because of its unique features compared with classic cadherins. We investigated the coexpression patterns of E-cadherin and liver intestine-cadherin in colorectal cancer, and determined whether differences in expression patterns were associated with clinicopathologic parameters and also which relationship between these two adhesion molecules existed in colorectal cancer. METHODS: Expression pattern of E-cadherin and liver intestine-cadherin was investigated immunohistochemically in 207 colorectal cancers along with clinicopathologic parameters. RESULTS: Reduced expression of liver intestine-cadherin was detected in 51 percent (n=105) of tumors. Such expression was found to be associated with tumoral dedifferentiation (P=0.015) and in a multivariate analysis was associated with a significant worse overall survival after adjustment for tumor stage, differentiation, and E-cadherin status (hazard ratio, 1.951; 95 percent confidence interval, 1.06-3.592; P=0.032). Fifteen percent (n=32) of tumors showed reduced expression of E-cadherin and had relationship with tumoral dedifferentiation (P<0.001), lymph node metastasis (P=0.004), and advanced stage (P=0.029). Reduced expression of E-cadherin was associated with short overall survival (P=0.028); however, in a multivariate analysis, it was not statistically significant. CONCLUSIONS: Reduced expression of liver intestine-cadherin had a significant correlation with tumoral dedifferentiation and short overall survival in this series. In addition, early and frequent loss of liver intestine-cadherin expression might be a more sensitive indicator than E-cadherin to predict more aggressive tumoral behavior.",
keywords = "Colorectal cancer, E-cadherin, Immunohistochemistry, Liver intestine-cadherin, Overall survival, Potential marker",
author = "Jung-Myun Kwak and Min, {Byung Wook} and Ju-Han Lee and Choi, {Jong Sang} and Lee, {Sun Il} and Sungsoo Park and Jin Kim and Um, {Jun Won} and Kim, {Seon Hahn} and Moon, {Hong Young}",
year = "2007",
month = "11",
day = "1",
doi = "10.1007/s10350-007-9034-1",
language = "English",
volume = "50",
pages = "1873--1880",
journal = "Diseases of the Colon and Rectum",
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TY - JOUR

T1 - The prognostic significance of E-cadherin and liver intestine-cadherin expression in colorectal cancer

AU - Kwak, Jung-Myun

AU - Min, Byung Wook

AU - Lee, Ju-Han

AU - Choi, Jong Sang

AU - Lee, Sun Il

AU - Park, Sungsoo

AU - Kim, Jin

AU - Um, Jun Won

AU - Kim, Seon Hahn

AU - Moon, Hong Young

PY - 2007/11/1

Y1 - 2007/11/1

N2 - PURPOSE: The significance of liver intestine-cadherin as a potential marker has been growing in the field of oncology, because of its unique features compared with classic cadherins. We investigated the coexpression patterns of E-cadherin and liver intestine-cadherin in colorectal cancer, and determined whether differences in expression patterns were associated with clinicopathologic parameters and also which relationship between these two adhesion molecules existed in colorectal cancer. METHODS: Expression pattern of E-cadherin and liver intestine-cadherin was investigated immunohistochemically in 207 colorectal cancers along with clinicopathologic parameters. RESULTS: Reduced expression of liver intestine-cadherin was detected in 51 percent (n=105) of tumors. Such expression was found to be associated with tumoral dedifferentiation (P=0.015) and in a multivariate analysis was associated with a significant worse overall survival after adjustment for tumor stage, differentiation, and E-cadherin status (hazard ratio, 1.951; 95 percent confidence interval, 1.06-3.592; P=0.032). Fifteen percent (n=32) of tumors showed reduced expression of E-cadherin and had relationship with tumoral dedifferentiation (P<0.001), lymph node metastasis (P=0.004), and advanced stage (P=0.029). Reduced expression of E-cadherin was associated with short overall survival (P=0.028); however, in a multivariate analysis, it was not statistically significant. CONCLUSIONS: Reduced expression of liver intestine-cadherin had a significant correlation with tumoral dedifferentiation and short overall survival in this series. In addition, early and frequent loss of liver intestine-cadherin expression might be a more sensitive indicator than E-cadherin to predict more aggressive tumoral behavior.

AB - PURPOSE: The significance of liver intestine-cadherin as a potential marker has been growing in the field of oncology, because of its unique features compared with classic cadherins. We investigated the coexpression patterns of E-cadherin and liver intestine-cadherin in colorectal cancer, and determined whether differences in expression patterns were associated with clinicopathologic parameters and also which relationship between these two adhesion molecules existed in colorectal cancer. METHODS: Expression pattern of E-cadherin and liver intestine-cadherin was investigated immunohistochemically in 207 colorectal cancers along with clinicopathologic parameters. RESULTS: Reduced expression of liver intestine-cadherin was detected in 51 percent (n=105) of tumors. Such expression was found to be associated with tumoral dedifferentiation (P=0.015) and in a multivariate analysis was associated with a significant worse overall survival after adjustment for tumor stage, differentiation, and E-cadherin status (hazard ratio, 1.951; 95 percent confidence interval, 1.06-3.592; P=0.032). Fifteen percent (n=32) of tumors showed reduced expression of E-cadherin and had relationship with tumoral dedifferentiation (P<0.001), lymph node metastasis (P=0.004), and advanced stage (P=0.029). Reduced expression of E-cadherin was associated with short overall survival (P=0.028); however, in a multivariate analysis, it was not statistically significant. CONCLUSIONS: Reduced expression of liver intestine-cadherin had a significant correlation with tumoral dedifferentiation and short overall survival in this series. In addition, early and frequent loss of liver intestine-cadherin expression might be a more sensitive indicator than E-cadherin to predict more aggressive tumoral behavior.

KW - Colorectal cancer

KW - E-cadherin

KW - Immunohistochemistry

KW - Liver intestine-cadherin

KW - Overall survival

KW - Potential marker

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U2 - 10.1007/s10350-007-9034-1

DO - 10.1007/s10350-007-9034-1

M3 - Article

VL - 50

SP - 1873

EP - 1880

JO - Diseases of the Colon and Rectum

JF - Diseases of the Colon and Rectum

SN - 0012-3706

IS - 11

ER -