The prognostic significance of E-cadherin and liver intestine-cadherin expression in colorectal cancer

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Abstract

PURPOSE: The significance of liver intestine-cadherin as a potential marker has been growing in the field of oncology, because of its unique features compared with classic cadherins. We investigated the coexpression patterns of E-cadherin and liver intestine-cadherin in colorectal cancer, and determined whether differences in expression patterns were associated with clinicopathologic parameters and also which relationship between these two adhesion molecules existed in colorectal cancer. METHODS: Expression pattern of E-cadherin and liver intestine-cadherin was investigated immunohistochemically in 207 colorectal cancers along with clinicopathologic parameters. RESULTS: Reduced expression of liver intestine-cadherin was detected in 51 percent (n=105) of tumors. Such expression was found to be associated with tumoral dedifferentiation (P=0.015) and in a multivariate analysis was associated with a significant worse overall survival after adjustment for tumor stage, differentiation, and E-cadherin status (hazard ratio, 1.951; 95 percent confidence interval, 1.06-3.592; P=0.032). Fifteen percent (n=32) of tumors showed reduced expression of E-cadherin and had relationship with tumoral dedifferentiation (P<0.001), lymph node metastasis (P=0.004), and advanced stage (P=0.029). Reduced expression of E-cadherin was associated with short overall survival (P=0.028); however, in a multivariate analysis, it was not statistically significant. CONCLUSIONS: Reduced expression of liver intestine-cadherin had a significant correlation with tumoral dedifferentiation and short overall survival in this series. In addition, early and frequent loss of liver intestine-cadherin expression might be a more sensitive indicator than E-cadherin to predict more aggressive tumoral behavior.

Original languageEnglish
Pages (from-to)1873-1880
Number of pages8
JournalDiseases of the colon and rectum
Volume50
Issue number11
DOIs
Publication statusPublished - 2007 Nov

Keywords

  • Colorectal cancer
  • E-cadherin
  • Immunohistochemistry
  • Liver intestine-cadherin
  • Overall survival
  • Potential marker

ASJC Scopus subject areas

  • Gastroenterology

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